Pharmacokinetic and pharmacodynamic drug interactions between digoxin and macrogol 4000, a laxative polymer, in healthy volunteers

British Journal of Clinical Pharmacology

Volumn 48, Issue 3, 1999, Pages 453-456

  Ragueneau, Isabelle ^a   Poirier, Jean Marie ^a   Radembino, Nathalie ^a   Sao, Anne Buu ^a   Funck Brentano, Christian ^a   Jaillon, Patrice ^a,b  

^a HÔPITAL SAINT ANTOINE   (France)

^b SORBONNE UNIVERSITÉ   (France)

Author keywords

Digoxin; Drug interaction; Healthy volunteers; Macrogol 4000; Pharmacodynamics; Pharmacokinetics

Indexed keywords

CARDIAC GLYCOSIDE; DIGOXIN; LAXATIVE; MACROGOL 4000; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; ATRIOVENTRICULAR CONDUCTION; BIOEQUIVALENCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; FEMALE; HEART RATE; HUMAN; HUMAN EXPERIMENT; INTESTINE ABSORPTION; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PR INTERVAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; CARDIOTONIC AGENTS; CATHARTICS; CROSS-OVER STUDIES; DIGOXIN; DOUBLE-BLIND METHOD; DRUG INTERACTIONS; FEMALE; HUMANS; MALE; POLYETHYLENE GLYCOLS;

EID: 0032867859     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1999.00025.x     Document Type: Article

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