Assessment of pharmacokinetic and pharmacodynamic drug interactions between nefazodone and digoxin in healthy male volunteers

Journal of Clinical Pharmacology

Volumn 36, Issue 2, 1996, Pages 160-167

  Dockens, Randy C ^a   Greene, Douglas S ^a   Barbhaiya, Rashmi H ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIGOXIN; DRUG METABOLITE; NEFAZODONE;

AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEPRESSION; DRUG MIXTURE; DRUG SCREENING; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHARMACODYNAMICS; RANDOMIZED CONTROLLED TRIAL;

EID: 0029878275     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1552-4604.1996.tb04181.x     Document Type: Article

References (23)

1. Rickels K, Schweizer E, Clary C, Fox I, Weise C: Nefazodone and imipramine in major depression: a placebo-controlled trial. Br J Psychiatry 1994;164:802-805.
2. Fontaine R, Ontiveros A, Elie R, Kensler TT, Roberts DL, Kaplita S, Ecker JA, Faludi G: A double-blind comparison of nefazodone, imipramine, and placebo in major depression. J Clin Psychiatry 1994;55:234-241.
3. Eison AS, Eison MS, Torrente JR, Wright RN, Yocca FD: Nefazodone: preclinical pharmacology of a new antidepressant. Psychopharmacol Bull 1990;26:311-315.
4. Kaul S, Shukla UA, Barbhaiya RH: Nonlinear pharmacokinetics of nefazodone after escalating single and multiple oral doses. J Clin Pharmacol 1995;35:830-839.
5. Mayol RF, Cole CA, Luke GM, Colson KL, Kerns EH: Characterization of the metabolites of the antidepressant drug nefazodone in human urine and plasma. Drug Metab Disp 1994;22:304-311.
6. Barbhaiya RH, Shukla UA, Chaikin P, Greene DS: Time to steady state after escalation and de-escalation of nefazodone bid doses. Eur J Clin Pharmacol (in press).
7. Barbhaiya RH, Shukla UA, Natarajan CS, Behr DA, Greene DS, Sainati SM: Single- and multiple-dose pharmacokinetics of nefazodone in subjects with hepatic cirrhosis. Clin Pharmacol Ther 1995;58:390-398.
8. Hoffman BF, Bigger JT Jr: Digitalis and allied cardiac glycosides. In, Gilman AG, Rall TW, Nies AS, Taylor P (eds.): The Pharmacological Basis of Therapeutics. Eighth edition. New York: Pergamon Press, 1990;814-834.
9. Beller GA, Smith TW, Abelmann WH, Haber E, Hood WB Jr: Digitalis intoxication: a prospective clinical study with serum level correlations. New Engl J Med 1971;284:989-997.
10. Smith TW: Digitalis toxicity: epidemiology and clinical use of serum concentration measurements. Am J Med 1975;58:470-476.
11. Franc JE, Duncan GF, Farmen RH, Pittman KA: High-performance liquid chromatographic method for the determination of nefazodone and its metabolites in human plasma using laboratory robotics. J Chromatogr 1991;570:129-138.
12. Gill JL: Design and Analysis of Experiments in the Animal and Medical Sciences. Ames, IA: Iowa State University Press, 1978.
13. Barbhaiya RH, Shukla UA, Greene DS: Coadministration of nefazodone and benzodiazepines. II. A pharmacokinetic interaction study with Triazolam. J Clin Psychopharmacol 1995;15:320-326.
14. Greene DS, Salazar DE, Dockens RC, Kroboth P, Barbhaiya RH: Coadministration of nefazodone and benzodiazepines. III. A pharmacokinetic interaction study with alprazolam. J Clin Psychopharmacol 1995;15:399-408.
15. Barbhaiya RH, Shukla UA, Greene DS, Midha KK, Breuel H-P: Investigation of pharmacokinetic and pharmacodynamic interactions following co-administration of nefazodone and haloperidol. J Clin Psychopharmacol (in press).
16. Rodin SM, Johnson BF: Pharmacokinetic interactions with digoxin. Clin Pharmacokinet 1988;15:227-244.
17. Ball Jr WJ, Tse-Eng D, Wallick ET, Bilezikian JP, Schwartz A, Butler VP Jr: Effect of quinidine on the digoxin receptor in vitro. J Clin Invest 1981;68:1065-1074.
18. Fenster PE, Kern KB: Common drug interactions with digoxin. Drug Ther Hosp 1983;13:91-94.
19. Belz GG, Aust PE, Munkes R: Digoxin plasma concentrations and nifedipine. Lancet 1981;1:844-845.
20. Moysey JO, Jaggarao NSV, Grundy EN, Chamberlain DA: Amiodarone increases plasma digoxin concentrations. Br Med J 1981;282:272.
21. Schwartz JB, Migliore PJ: Effect of nifedipine on serum digoxin concentration and renal digoxin clearance. Clin Pharmacol Ther 1984;36:19-24.
22. Rauch PK, Jenike MA: Digoxin toxicity possibly precipitated by trazodone, Psychosomatics 1984;25:334-335.
23. Saner HE, Lange HW, Pierach CA, Aeppli DM: Relation between serum digoxin concentration and the electrocardiogram. Clin Cardiol 1988;11:752-756.