Drosophila choline acetyltransferase temperature-sensitive mutants

Neurochemical Research

Volumn 24, Issue 8, 1999, Pages 1081-1087

  Wang, Weiya ^a   Kitamoto, Toshihiro ^a   Salvaterra, Paul M ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Choline acetyltransferase; Drosophila; Temperature sensitive mutants

Indexed keywords

CHOLINE ACETYLTRANSFERASE; MESSENGER RNA; MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA; ENZYME POLYMORPHISM; HETEROZYGOTE; HOMOZYGOTE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA ANALYSIS; SEQUENCE ANALYSIS; TEMPERATURE SENSITIVE MUTANT; TEMPERATURE SENSITIVITY;

ALLELES; ANIMALS; BASE SEQUENCE; CHOLINE O-ACETYLTRANSFERASE; DNA PRIMERS; DROSOPHILA; HETEROZYGOTE; HOMOZYGOTE; MUTATION; RECEPTORS, CHOLINERGIC; RNA, MESSENGER; SYNAPTIC TRANSMISSION; TEMPERATURE; XENOPUS;

ANIMALIA; DROSOPHILA MELANOGASTER; INSECTA; MELANOGASTER;

EID: 0032867807     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021021213625     Document Type: Article

References (18)

1. Wu, D., and Hersh, L. B. 1994. Choline acetyltransferase: celebrating its fiftieth year. J Neurochem 62:1653-63.
2. Salvaterra, P. M., and Vaughn, J. E. 1989. Regulation of choline acetyltransferase. International Rev. Neurobiol. 31:81-143.
3. Bartus, R. T., Dean, R. L. d., Beer, B., Lippa, A. S. 1982. The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408-14.
4. Davies, P. 1983. The neurochemistry of Alzheimer's disease and senile dementia. Med Res Rev 3:221-36.
5. Itoh, N., Slemmon, J. R., Hawke, D. H., Williamson, R. H., Morita, E., Itakura, K., Roberts, E., Shively, J. E., Crawford, G. D., Salvaterra, P. M. 1986. Cloning of Drosophila choline acetyltransferase cDNA. Proc. Natl. Acad. Sci. USA 83:4081-4085.
6. Greenspan, R. J. 1980. Mutations of choline acetyltransferase and associated neural defects in Drosophila melanogaster. J. Comp. Physiol. 137:83-92.
7. Tajima, T., Salvaterra, P. M. 1990. Sequence of choline acetyltransferase temperature-sensitive mutants determined by the polymerase chain reaction. Neuroscience 39:245-250.
8. Singer-Sam, J., LeBon, J. M., Dai, A., Riggs, A. D. 1992. A sensitive, quantitative assay for measurement of allele-specific transcripts differing by a single nucleotide. PCR Meth. Appl. 1:160-163.
9. Greenwood, A. D., Burke, D. T. 1996. Single nucleotide primer extension: quantitative range, variability, and multiplex analysis. Genome Res 6:336-48.
10. Kitamoto, T., Wang, W., Salvaterra, P. M. 1998. Structure and organization of the Drosophila cholinergic locus. J Biol Chem 273:2706-13.
11. Sugihara, H., Andrisani, V., Salvaterra, P. M. 1990. Drosophila choline acetyltransferase uses a non-AUG initiation codon and full length RNA is inefficiently translated. J. Biol. Chem. 265:21714-21719.
12. McCaman, R. E., Carbini, L., Maines, V., Salvaterra, P. M. 1988. Single RNA species injected into Xenopus oocyte directs the synthesis of active choline acetyltransferase. Molec. Brain Res. 3:107-114.
13. Salvaterra, P. M., McCaman, R. E. 1985. Choline acetyltranferase and acetylcholine levels in Drosophila melanogaster: A study using two temperature-sensitive mutants. J. Neurosci. 5:903-910.
14. Takagawa, K., Salvaterra, P. 1996. Analysis of choline acetyltransferase protein in temperature sensitive mutant flies using newly generated monoclonal antibody. Neurosci Res 24:237-43.
15. Sugihara, H., Andrisani, V., Salvaterra, P. M. 1991. Genomic organization of Drosophila choline acetyltransferase. J. Neurochem. 57:1636-1642.
16. Carbini, L. A., Hersh, L. B. 1993. Functional analysis of conserved histidines in choline acetyltransferase by site-directed mutagenesis. J Neurochem 61:247-53.
17. Gorczyca, M., Hall, J. C. 1984. Identification of a cholinergic synapse in the giant fiber pathway of Drosophila using conditional mutations of acetylcholine synthesis. J Neurogenet 1:289-313.
18. Yasuyama, K., Kitamoto, T., Salvaterra, P. M. 1996. Differential regulation of choline acetyltransferase expression in adult Drosophila melanogaster brain. J Neurobiol 30:205-18.