Roles of potassium channels and nitric oxide in modulation of uterine contractions in rat pregnancy

American Journal of Obstetrics and Gynecology

Volumn 181, Issue 3, 1999, Pages 649-655

  Okawa, Toshiaki ^a   Vedernikov, Yuri P ^a   Saade, George R ^a   Longo, Monica ^a   Olson, Gayle L ^a   Chwalisz, Kristof ^b   Garfield, Robert E ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b BAYER PHARMA AG   (Germany)

Author keywords

Adenosine triphosphate dependent potassium channels; Calcium dependent potassium channels; Myometrium; Nitric oxide; Pregnancy

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; NITRIC OXIDE; POTASSIUM CHANNEL; TETRABUTYLAMMONIUM; TETRYLAMMONIUM;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GESTATIONAL AGE; MYOMETRIUM; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RAT; REFRACTORY PERIOD; SIGNAL TRANSDUCTION; UTERUS CONTRACTILITY;

EID: 0032866790     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9378(99)70508-9     Document Type: Article

References (27)

1. 1. Piper I, Minshall E, Downing SJ, Hollingsworth M, Sadraci H. Effects of several potassium channel openers and glibenclamide on the uterus of Ihe rat. Br J Pharmacol 1990;101:901-7.
2. + channels in pregnant rat myometrium: modulation by β-adrenergic agent. Am J Physiol 1992;263:C1049-56.
3. 3. Tritthart HA, Mahnert W, Fleischhacker A, Adelwohrer N. Potassium channels and modulating factors of channel functions in the human myometrium. Z Kardiol 1991;80(Suppl 7):29-33.
4. + channels in nonlabor and labor human uterine myocytes. Am J Physiol 1997;273:C1721-31.
5. 5. Khan RN, Smith SK, Ashford ML. Contribution of calcium-sensitive potassium channels to NS1619-induced relaxation in human pregnant myometrium. Hum Reprod 1998;13:208-13.
6. 6. Chenk JM, Hollingsworth M, Hughes SJ, Piper IT, Maresh MJ. Inhibition of contractions of the isolated human myometrium by potassium channel openers. Am J Obstet Gynecol 1993;169:953-60.
7. 7. Morrison JJ, Ashford ML, Khan RN, Smith SK. The effects of potassium channel openers on isolated pregnant human myometrium before and after the onset of labor: potential for tocolysis. Am J Obstet Gynecol 1993;169:1277-85.
8. 8. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 1991;43:109-42.
9. 9. Isumi H, Yallampalli C, Garfield RE. Gestational changes in L-arginine-induced relaxation of pregnant rat and human myometrial smooth muscle. Am J Obstet Gynecol 1993;169:1327-37.
10. 10. Yallampalli C, Izumi H, Byan-Smith M, Garfield RE. An L-arginine-nitric oxide-cyclic guanosine monophosphate system exists in the uterus and inhibits contractility during pregnancy. Am J Obstet Gynecol 1993;170:175-85.
11. 11. Sladek SM, Roberts JM. Nitric oxide synthase activity in the gravid rat uterus decreases a day before the onset of parturition. Am J Obstet Gynecol 1996;175:1661-7.
12. 12. Hennan JK, Diamond J. Evidence that spontaneous contractile activity in the rat myometrium is not inhibited by NO-mediated increase in tissue levels of cyclic GMP. Br J Pharmacol 1988;123:959-67.
13. 13. Robertson RE, Schubert R, Hescheler J, Nelson MT. CGMP-dependent protein kinase actívates Ca-activated K channels in cerebral artery smooth muscle cells. Am J Physiol 1993;265:C299-303.
14. 14. Bolotina VM, Najibi S, Palacino JJ, Pagano PJ, Cohen RA. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature 1994;368:850-3.
15. 15. Li PL, Jin MW, Campbell WB. Effect of selective inhibition of soluble guanylate cyclase on the kA channel activity in coronary artery smooth muscle. Hypertension 1998;31:303-8.
16. Ca channels antagonizes NO-induced relaxation in pulmonary artery. Am J Physiol 1977;272:H904-12.
17. Ca channel antagonists reduce NO donor-mediated relaxation of vascular and tracheal smooth muscle. Am J Physiol 1995;268:L152-9.
18. + channels in relaxation of hypercholesterolemic rabbit carotid artery to NO. Am J Physiol 1995;269:H805-11.
19. 19. Murphy ME, Brayden JE. Nitric oxide hyperpolarizes rabbit mesenteric arteries via ATP-sensitive potassium channels. J Physiol 1995;486:47-58.
20. + channel, ROMK. Proc Soc Exp Biol Med 1977;216:57-64.
21. 21. Sanborn BM. Ion channels and control of myometrial electrical activity. Semin Perinatol 1955;19:31-40.
22. 22. Edwards G, Weston AH. Potassium channel openers and vascular smooth muscle relaxation. Pharmacol Ther 1990;8:237-58.
23. + channels by novel benzimidazolone. Eur J Pharmacol 1994;251:53-9.
24. 24. Standen NB, Quayle JM, Davis NW, Brayden JI, Huang Y, Nelson TM. Hyperpolarizing vasodilators activate ATP-sensitive potassium channels in arterial smooth muscle. Science 1989;245:177-80.
25. 25. Cook NS, Quast U. Potassium channel pharmacology. In: Cook NS, editor. Potassium channels: structure, classification, function and therapeutic potential. Chichester (United Kingdom): Ellis Horwood; 1990. p. 181-255.
26. 26. Lischke V, Busse R, Hecker M. Selective inhibition by barbitu rates of the synthesis of endothelium-derived hyperpoladzing factor in the rabbit carotid artery. Br J Pharmacol 1995;115:969-74.
27. 27. Maragos CM, Morley D, Wink DA, Dunams TM, Saavedra JE, Hoffman A, et al. Complexes of nitric oxide with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. J Med Chem 1991;34:3242-7.