Renal effects of efonidipine hydrochloride, a new calcium antagonist, in spontaneously hypertensive rats with glomerular injury

Clinical and Experimental Pharmacology and Physiology

Volumn 26, Issue 9, 1999, Pages 674-679

  Kawabata, Masahiko ^a   Ogawa, Tetsaya ^a   Han, Wen Hua ^a   Takabatake, Toshikazu ^a  

^a SHIMANE UNIVERSITY   (Japan)

Author keywords

Afferent arteriole; Efferent arteriole; Intraglomerular pressure; Proteinuria; Renal haemodynamics; Superficial nephron; Tubuloglomerular feedback

Indexed keywords

CALCIUM ANTAGONIST; EFONIDIPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DRUG EFFECT; FEEDBACK SYSTEM; GLOMERULOPATHY; HENLE LOOP; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY INJURY; KIDNEY PERFUSION; KIDNEY VASCULAR RESISTANCE; MALE; NONHUMAN; RAT;

ANIMALS; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; DIHYDROPYRIDINES; GLOMERULAR FILTRATION RATE; KIDNEY; KIDNEY GLOMERULUS; KIDNEY TUBULES, PROXIMAL; MALE; NITROPHENOLS; ORGANOPHOSPHORUS COMPOUNDS; PROTEINURIA; RATS; RATS, INBRED SHR; RENAL CIRCULATION;

EID: 0032862216     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.1999.03114.x     Document Type: Article

References (33)

1. Shudo S, Masuda Y, Sugita H et al. Renal protective effect of efonidipine hydrochloride (NZ-105), a new calcium antagonist, in spontaneously hypertensive rats. Gen. Pharmacol. 1994; 25: 1567-75.
2. Shudo S, Masuda Y, Sugita H, Tanaka S, Tomita K. Beneficial effect of efonidipine hydrochloride (NZ-105) on proteinuria in aged spontaneously hypertensive rats. Pharm. Sci. 1995; 1: 333-5.
3. Yamada K, Ishii M, Abe K et al. [Effects and usefulness of NZ-105 in hypertensive patients associated with renal impairment.] Jpn. Pharmacol. Ther. 1991; 19: 4903-22. (In Japanese.)
4. Hayashi K, Nagahama T, Oka K, Epstein M, Saruta T. Disparate effects of calcium antagonist on renal microcirculation. Hypertens. Res. 1996; 19; 31-6.
5. Arima S, Ito S, Omata K, Tsunoda K, Yaoita K, Abe K, Diverse hemodynamic effects of calcium channel blockade in renal microcirculation. J. Hypertens. 1996; 14 (Suppl. 1): S45 (Abstract).
6. Schnermann J, Briggs JP. Function of juxtaglomerular apparatus: Control of glomerular hemodynamics and renin secretion. In: Seldin DW, Giebisch G (ed.). The Kidney: Physiology and Pathophysiology, 2nd edn. Raven Press, New York, 1992; 1249-89.
7. Ploth DW, Dahlheim H, Schmidmeier E, Hermle M, Schnermann J. Tubuloglomerular feedback and autoregulation of glomerular filtration rate in Wistar-Kyoto spontaneously hypertensive rats. Pflügers Arch. 1978; 375: 261-7.
8. Dilly J, Arendshorst W. Enhanced tubuloglomerular feedback activity in rats developing spontaneous hypertension. Am. J. Physiol. 1984; 247: F810-20.
9. Takabatake T, Ushiogi Y, Hattori N. Effects of volume replacement on tubuloglomerular feedback activity in spontaneously hypertensive rats. In: Persson AEG, Boberg U (eds). The Juxtaglomerular Apparatus. Elsevier, Amsterdam. 1988; 289-96.
10. Takabatake T, Ushiogi Y, Ohta K, Hattori N. Attenuation of enhanced tubuloglomerular feedback activity in SHR by renal denervation. Am. J. Physiol. 1990; 258: F980-5.
11. Takabatake T, Ushiogi Y, Ise T. Kobayashi K. Effect of calcium antagonist, manidipine hydrochloride, on renal hemodynamics and tubuloglomerular feedback in spontaneously hypertensive rats. Am. Heart J. 1993; 125:578-81.
12. Takabatake T, Ise T, Ohta K, Kobayashi K. Effects of endothelin on renal hemodynamics and tubuloglomerular feedback. Am. J. Physiol. 1992; 263: F103-8.
13. Häberle DA, Davis JM, Kawabata M, Metz C, Wapler P, Stachl M, Renal and single-nephron function is comparable in thiobutabarbitone- and thiopentone-anesthetized rats. Pflügers Arch. 1993; 424: 224-30.
14. Führ KJ, Kaczmrczyk J, Krüttgen CD. Eine einfache colorimetrische Methode zur Inulinbestimmung für Nieren-Clearance-Untersuchungen bei Stoffwechselgesunden und Diabetikern. Klin. Wochenschr. 1955; 33: 729-30.
15. Briggs J. A simple steady-state model for feedback control of glomerular filtration rate. Kidney Int. 1982; 22 (Suppl. 12): S143-50.
16. Briggs J, Schubert G. Schnermann J. Quantitative characterization of the tubuloglomerular feedback response: Effect of growth. Am. J. Physiol. 1984; 247: F808-15.
17. Schnermann J, Briggs JP. Interaction between loop of Henle flow and arterial pressure as determinants of glomerular pressure. Am. J. Physiol. 1989; 256: F421-9.
18. Babu T, Ishizaki T, Murabayashi S, Aoyagi K, Tamasawa N, Takebe K. Multiple oral doses of nicardipine, a calcium-entry blocker: Effects on renal function, plasma renin activity, and aldosterone concentration in mild-to-moderate essential hypertension. Clin Pharmacol. Ther. 1987; 42: 232-9.
19. Takabatake T, Ohta H, Yamamoto Y et al. [Renal function during anti-hypertensive therapy with a calcium antagonist, nilvadipine.] Jpn. Pharmacol. Ther. 1989; 17: 285-90. (In Japanese.)
20. Lupinacci L, Palomino C, Greenberg A, Puschett JB, Chronic effects of nitrendipine on renal hemodynamics and tubular transport. Clin. Pharmacol. Ther. 1988; 434: 6-15.
21. Tojo A, Kimura K, Matsuoka H, Sugimoto T. Effects of manidipine hydrochloride on the renal microcirculation in spontaneously hypertensive rats. J. Cardiovasc. Pharmacol. 1992; 20: 895-9.
22. Takabatake T, Ohta H, Sasaki T et al. [Effects of a new calcium antagonist, manidipine hydrochloride on renal function in hypertensive patients.] Rinsyo-lyaku 1989; 5: 1177-83. (In Japanese.)
23. Häberle DA. Hemodynamic interactions between intrinsic blood flow control mechanisms in the rat kidney. Renal Physiol. Biochem. 1988; 11: 289-315.
24. Davis JM, Kawata T, Häberle DA. The influence of renal autoregulation on TGF control of glomerular filtration rate. In: Persson AEG, Boberg U (eds). The Juxtoglomerular Apparatus. Elsevier, Amsterdam. 1988; 393-406.
25. Mitchell KD, Navar LG. Tubuloglomerular feedback responses during peritubular infusions of calcium channel blockers. Am. J. Physiol. 1990; 258: F537-44.
26. Carmines PK, Navar LG. Disparate effects of Ca channel blockade on afferent and efferent arteriolar responses to ANG II. Am. J. Physiol. 1989; 256: F1015-20.
27. Fleming JT, Parekh N, Steinhausen M. Calcium antagonists preferentially dilate preglomerular vessels of hydronephrotic kidney. Am. J. Physiol. 1987; 253: F1157-63.
28. Takenaka T, Harrison-Bernard LM, Inscho EW, Carmines PK, Navar LG. Autoregulation of afferent anteriolar blood flow in juxtamedullary nephrons. Am. J. Physiol. 1994; 267: F879-87.
29. Ito S, Juncos LA, Carretero OA. Pressure-induced constriction of the afferent arteriole of spontaneously hypertensive rats. Hypertension 1992; 19 (Suppl. 11): 11-164-7.
30. Lafayette RA, Mayer G, Park SK, Meyer TW. Angiotensin II receptor blockade limits glomerular injury in rats with reduced renal mass. J. Clin. Invest. 1992; 90: 766-71.
31. Dworkin LD, Benstein JA, Parker M, Tolbert E, Feiner IID. Calcium antagonists and converting enzyme inhibitors reduce renal injury by different mechanisms. Kidney Int. 1993; 43: 808-14.
32. Hamaguchi A, Kim S, Wanibuchi H, Iwao H. Angiotensin II and calcium blockers prevent glomerular phenotypic changes in remnant kidney model. J. Am. Soc. Nephrol. 1996; 7: 687-93.
33. Feld LG, Cachero S, Van Liew JB, Zamlauski-Tucker M, Noble B. Enalapril and renal injury in spontaneously hypertensive rats. Hypertension 1990; 16: 544-54.