-
1
-
-
0027535473
-
Pharmacokinetic modeling of trichloroethylene and trichloroacetic acid in humans
-
Allen B. D., Fisher J. W. Pharmacokinetic modeling of trichloroethylene and trichloroacetic acid in humans. Risk Anal. 13:1993;71-86.5.
-
(1993)
Risk Anal.
, vol.13
, pp. 71-865
-
-
Allen, B.D.1
Fisher, J.W.2
-
2
-
-
0025009192
-
Chemical carcinogenesis: Too many rodent carcinogens
-
Ames B. N., Gold L. S. Chemical carcinogenesis: Too many rodent carcinogens. Proc. Natl. Acad. Sci. USA. 87:1990;7772-7776.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 7772-7776
-
-
Ames, B.N.1
Gold, L.S.2
-
3
-
-
0029135146
-
Negative selection in hepatic tumor promotion in relation to cancer risk assessment
-
Andersen M. E., Mills J. J., Jirtle R. L., Greenlee W. F. Negative selection in hepatic tumor promotion in relation to cancer risk assessment. Toxicology. 120:1995;223-237.
-
(1995)
Toxicology
, vol.120
, pp. 223-237
-
-
Andersen, M.E.1
Mills, J.J.2
Jirtle, R.L.3
Greenlee, W.F.4
-
5
-
-
84889551557
-
National Toxicology Program studies: Principles of dose selection and applications to mechanistic based risk assessment
-
Bucher J. R., Portier C. J., Goodman J. I., Faustman E. M., Lucier G. W. National Toxicology Program studies: Principles of dose selection and applications to mechanistic based risk assessment. Fundam. Appl. Toxicol. 31:1966;1-8.
-
(1966)
Fundam. Appl. Toxicol.
, vol.31
, pp. 1-8
-
-
Bucher, J.R.1
Portier, C.J.2
Goodman, J.I.3
Faustman, E.M.4
Lucier, G.W.5
-
6
-
-
0027253691
-
The role of dichloroacetate in the hepatocarcinogenicity of trichloroethylene
-
Bull R. J., Templin M., Larson J. L., Stevens D. K. The role of dichloroacetate in the hepatocarcinogenicity of trichloroethylene. Toxicol. Lett. 68:1993;203-211.
-
(1993)
Toxicol. Lett.
, vol.68
, pp. 203-211
-
-
Bull, R.J.1
Templin, M.2
Larson, J.L.3
Stevens, D.K.4
-
7
-
-
0029069484
-
A strategy for establishing mode of action of chemical carcinogens as a guide for approaches to risk assessment
-
Butterworth B. E., Conolly R. B., Morgan K. T. A strategy for establishing mode of action of chemical carcinogens as a guide for approaches to risk assessment. Cancer Lett. 93:1995;129-146.
-
(1995)
Cancer Lett.
, vol.93
, pp. 129-146
-
-
Butterworth, B.E.1
Conolly, R.B.2
Morgan, K.T.3
-
9
-
-
0029150885
-
Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: Examples with vinyl chloride and trichloroethylene
-
Clewell H. J., Gentry P. R., Gearhart J. M., Allen B. C., Andersen M. E. Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: Examples with vinyl chloride and trichloroethylene. Chemosphere. 31:1995;2561-2578.
-
(1995)
Chemosphere
, vol.31
, pp. 2561-2578
-
-
Clewell, H.J.1
Gentry, P.R.2
Gearhart, J.M.3
Allen, B.C.4
Andersen, M.E.5
-
10
-
-
0027102025
-
Risk assessment based on high-dose animal exposure experiments
-
Cohen S. M., Ellwein L. B. Risk assessment based on high-dose animal exposure experiments. Chem. Res. Toxicol. 5:1992;742-748.
-
(1992)
Chem. Res. Toxicol.
, vol.5
, pp. 742-748
-
-
Cohen, S.M.1
Ellwein, L.B.2
-
12
-
-
0029556798
-
Biologically based dose response model for hepatic toxicity: A mechanistically based replacement for traditional estimates of noncancer risk
-
Conolly R. B., Butterworth B. E. Biologically based dose response model for hepatic toxicity: A mechanistically based replacement for traditional estimates of noncancer risk. Toxicol. Lett. 82/83:1995;901-906.
-
(1995)
Toxicol. Lett.
, vol.8283
, pp. 901-906
-
-
Conolly, R.B.1
Butterworth, B.E.2
-
13
-
-
0025234377
-
Development of a physiologically-based pharmacokinetic model for chloroform
-
Corley R. A., Mendrala A. L., Smith F. A., Staats D. A., Gargas M. L., Conolly R. B., Andersen M. E., Reitz R. H. Development of a physiologically-based pharmacokinetic model for chloroform. Toxicol. Appl. Pharmacol. 103:1990;512-527.
-
(1990)
Toxicol. Appl. Pharmacol.
, vol.103
, pp. 512-527
-
-
Corley, R.A.1
Mendrala, A.L.2
Smith, F.A.3
Staats, D.A.4
Gargas, M.L.5
Conolly, R.B.6
Andersen, M.E.7
Reitz, R.H.8
-
14
-
-
0028559017
-
Hypomethylation of DNA: An epigenetic mechanism involved in tumor promotion
-
Counts J. L., Goodman J. I. Hypomethylation of DNA: An epigenetic mechanism involved in tumor promotion. Mol. Carcinogen. 11:1994;185-188.
-
(1994)
Mol. Carcinogen
, vol.11
, pp. 185-188
-
-
Counts, J.L.1
Goodman, J.I.2
-
15
-
-
0029061206
-
Principles underlying dose selection for, and extrapolation from, the carcinogen bioassay: Dose influences mechanism
-
Counts J. L., Goodman J. I. Principles underlying dose selection for, and extrapolation from, the carcinogen bioassay: Dose influences mechanism. Regul. Toxicol. Pharmacol. 21:1995a;418-421.
-
(1995)
Regul. Toxicol. Pharmacol.
, vol.21
, pp. 418-421
-
-
Counts, J.L.1
Goodman, J.I.2
-
16
-
-
0028839835
-
Alterations in DNA methylation may play a variety of roles in carcinogenesis
-
Counts J. L., Goodman J. I. Alterations in DNA methylation may play a variety of roles in carcinogenesis. Cell. 83:1995b;13-15.
-
(1995)
Cell
, vol.83
, pp. 13-15
-
-
Counts, J.L.1
Goodman, J.I.2
-
17
-
-
17144460958
-
Hypomethylation of DNA: A nongenotoxic mechanism involved in tumor promotion
-
Counts J. L., Goodman J. I. Hypomethylation of DNA: A nongenotoxic mechanism involved in tumor promotion. Toxicol. Lett. 82/83:1995c;663-672.
-
(1995)
Toxicol. Lett.
, vol.8283
, pp. 663-672
-
-
Counts, J.L.1
Goodman, J.I.2
-
19
-
-
0029934579
-
Cell proliferation and global methylation status changes in mouse liver after phenobarbital and/or choline-devoid, methionine deficient diet administration
-
Counts J. L., Sarmiento J .I., Harbison M. L., Downing J. C., McClain R. M., Goodman J. I. Cell proliferation and global methylation status changes in mouse liver after phenobarbital and/or choline-devoid, methionine deficient diet administration. Carcinogenesis. 17:1996;1251-1257.
-
(1996)
Carcinogenesis
, vol.17
, pp. 1251-1257
-
-
Counts, J.L.1
Sarmiento, J.I.2
Harbison, M.L.3
Downing, J.C.4
McClain, R.M.5
Goodman, J.I.6
-
20
-
-
0026346879
-
Consideration of the target organ toxicity of trichloroethylene in terms of metabolite toxicity and pharmacokinetics
-
Davidson I. W. F., Beliles R. P. Consideration of the target organ toxicity of trichloroethylene in terms of metabolite toxicity and pharmacokinetics. Drug Metab. Rev. 23:1991;493-495.
-
(1991)
Drug Metab. Rev.
, vol.23
, pp. 493-495
-
-
Davidson, I.W.F.1
Beliles, R.P.2
-
21
-
-
0001354674
-
Induction of hepatomas in mice by repeated oral administration of chloroform with observations on sex differences
-
Eschenbrenner A. B., Miller E. Induction of hepatomas in mice by repeated oral administration of chloroform with observations on sex differences. J. Natl. Cancer Inst. 5:1945;251-255.
-
(1945)
J. Natl. Cancer Inst.
, vol.5
, pp. 251-255
-
-
Eschenbrenner, A.B.1
Miller, E.2
-
22
-
-
0011153427
-
The carcinogen bioassay in perspective: A requirement for incorporation of biological information
-
Goodman J. I. The carcinogen bioassay in perspective: A requirement for incorporation of biological information. In Vitro Toxicol. 3:1990;1-7.
-
(1990)
In Vitro Toxicol.
, vol.3
, pp. 1-7
-
-
Goodman, J.I.1
-
23
-
-
0028125906
-
A rational approach to risk assessment requires the use of biological information: An analysis of the National Toxicology Program (NTP) final report of the advisory review by the NTP Board of Scientific Counselors
-
Goodman J. I. A rational approach to risk assessment requires the use of biological information: An analysis of the National Toxicology Program (NTP) final report of the advisory review by the NTP Board of Scientific Counselors. Reg. Toxicol. Pharmacol. 19:1994;51-59.
-
(1994)
Reg. Toxicol. Pharmacol.
, vol.19
, pp. 51-59
-
-
Goodman, J.I.1
-
24
-
-
0029072307
-
An analysis of the National Toxicology Program's (NTP) technical report (NTP TR 421) on the toxicology and carcinogenesis studies of talc
-
Goodman J. I. An analysis of the National Toxicology Program's (NTP) technical report (NTP TR 421) on the toxicology and carcinogenesis studies of talc. Regul. Toxicol. Pharmacol. 21:1995;244-249.
-
(1995)
Regul. Toxicol. Pharmacol.
, vol.21
, pp. 244-249
-
-
Goodman, J.I.1
-
25
-
-
77957187759
-
The relationship between use of the maximum tolerated dose and study sensitivity for detecting rodent carcinogenicity
-
Haseman J. K., Lockhart A. The relationship between use of the maximum tolerated dose and study sensitivity for detecting rodent carcinogenicity. Fundam. Appl. Toxicol. 22:1994;382-391.
-
(1994)
Fundam. Appl. Toxicol.
, vol.22
, pp. 382-391
-
-
Haseman, J.K.1
Lockhart, A.2
-
26
-
-
0018320392
-
Safety evaluation of toothpaste containing chloroform. III. Long-term study in beagle dogs
-
Heywood R., Sortwell R. J., Noel P. R. B., Street A. E., Prentice D. E., Roe F. J. C., Wadsworth P. F., Worden A. N., Van Abbe N. J. Safety evaluation of toothpaste containing chloroform. III. Long-term study in beagle dogs. J. Environ. Pathol. Toxicol. 2:1979;835-851.
-
(1979)
J. Environ. Pathol. Toxicol.
, vol.2
, pp. 835-851
-
-
Heywood, R.1
Sortwell, R.J.2
Noel, P.R.B.3
Street, A.E.4
Prentice, D.E.5
Roe, F.J.C.6
Wadsworth, P.F.7
Worden, A.N.8
Van Abbe, N.J.9
-
27
-
-
0022380668
-
Carcinogenicity of chloroform in drinking water to male Osborne-Mendel rats and female B6C3F1 mice
-
Jorgenson T. A., Meierhenry E. F., Rushbrook C. J., Bull R. J., Robinson M. Carcinogenicity of chloroform in drinking water to male Osborne-Mendel rats and female B6C3F1 mice. Fundam. Appl. Toxicol. 5:1985;760-769.
-
(1985)
Fundam. Appl. Toxicol.
, vol.5
, pp. 760-769
-
-
Jorgenson, T.A.1
Meierhenry, E.F.2
Rushbrook, C.J.3
Bull, R.J.4
Robinson, M.5
-
29
-
-
77957182670
-
Induced cytolethality and regenerative cell proliferation in the livers and kidneys of male B6C3F1 mice given chloroform by gavage
-
Larson J. L., Wolf D. C., Butterworth B. E. Induced cytolethality and regenerative cell proliferation in the livers and kidneys of male B6C3F1 mice given chloroform by gavage. Fundam. Appl. Toxicol. 23:1994b;537-543.
-
(1994)
Fundam. Appl. Toxicol.
, vol.23
, pp. 537-543
-
-
Larson, J.L.1
Wolf, D.C.2
Butterworth, B.E.3
-
30
-
-
77957186700
-
-
Induced cytotoxicity and cell proliferation in the hepatocarcinogenicity of chloroform in female B6C3F1 mice: Comparison of administration by gavage in corn oil vs. ad libitum in drinking water.
-
Larson J. L., Wolf D. C., Butterworth B. E. Induced cytotoxicity and cell proliferation in the hepatocarcinogenicity of chloroform in female B6C3F1 mice: Comparison of administration by gavage in corn oil vs. ad libitum in drinking water. Fundam. Appl. Toxicol. 22:1994c;90-102.
-
(1994)
Fundam. Appl. Toxicol.
, vol.22
, pp. 90-102
-
-
Larson, J.L.1
Wolf, D.C.2
Butterworth, B.E.3
-
31
-
-
0028985435
-
Induced regenerative cell proliferation in livers and kidneys of male F344 rats given chloroform in corn oil by gavage or ad libitum in drinking water
-
Larson J. L., Wolf D. C., Butterworth B. E. Induced regenerative cell proliferation in livers and kidneys of male F344 rats given chloroform in corn oil by gavage or ad libitum in drinking water. Toxicology. 95:1995a;73-86.
-
(1995)
Toxicology
, vol.95
, pp. 73-86
-
-
Larson, J.L.1
Wolf, D.C.2
Butterworth, B.E.3
-
32
-
-
0029014927
-
Toxicity and cell proliferation in the liver, kidneys and nasal passages of female F344 rats, induced by chloroform administered by gavage
-
Larson J. L., Wolf D. C., Mery S., Morgan K. T., Butterworth B. E. Toxicity and cell proliferation in the liver, kidneys and nasal passages of female F344 rats, induced by chloroform administered by gavage. Food Chem. Toxicol. 33:1995b;443-456.
-
(1995)
Food Chem. Toxicol.
, vol.33
, pp. 443-456
-
-
Larson, J.L.1
Wolf, D.C.2
Mery, S.3
Morgan, K.T.4
Butterworth, B.E.5
-
33
-
-
0002656037
-
Mechanistic considerations in the regulation and classification of chemical carcinogens
-
F.N. Kotsonis, M. Mackey, & J. Hjelle. NY: Raven Press
-
McClain R. M. Mechanistic considerations in the regulation and classification of chemical carcinogens. Kotsonis F. N., Mackey M., Hjelle J. Nutritional Toxicology. 1994;273-304 Raven Press, NY.
-
(1994)
Nutritional Toxicology
, pp. 273-304
-
-
McClain, R.M.1
-
34
-
-
0026638257
-
Does chemically induced hepatocyte proliferation predict liver carcinogenesis?
-
Melnick R. L. Does chemically induced hepatocyte proliferation predict liver carcinogenesis? FASEB J. 6:1992;2698-2706.
-
(1992)
FASEB J.
, vol.6
, pp. 2698-2706
-
-
Melnick, R.L.1
-
35
-
-
0016806538
-
Metabolism of trichloroethylene in man. III. Interaction of trichloroethylene and ethanol
-
Muller G., Spassovski M., Henschler D. Metabolism of trichloroethylene in man. III. Interaction of trichloroethylene and ethanol. Arch. Toxicol. 33:1975;173.
-
(1975)
Arch. Toxicol.
, vol.33
, pp. 173
-
-
Muller, G.1
Spassovski, M.2
Henschler, D.3
-
39
-
-
0026785626
-
A mechanism for the development of Clara cell lesions in the mouse lung after exposure to trichloroethylene
-
Odum J., Foster J. R., Green T. A mechanism for the development of Clara cell lesions in the mouse lung after exposure to trichloroethylene. Chem-Biol. Interact. 83:1992;135-153.
-
(1992)
Chem-Biol. Interact.
, vol.83
, pp. 135-153
-
-
Odum, J.1
Foster, J.R.2
Green, T.3
-
40
-
-
0003087212
-
Biochemical toxicology of chloroform
-
Hodgson, Bend, & Philpot. New York: Elsevier
-
Pohl L. Biochemical toxicology of chloroform. Hodgson, Bend, Philpot. Reviews in Biochemical Toxicology. 1979;79-107 Elsevier, New York.
-
(1979)
Reviews in Biochemical Toxicology
, pp. 79-107
-
-
Pohl, L.1
-
41
-
-
0028356046
-
Alterations in the methylation status and expression of the raf oncogene in phenobarbital-induced and spontaneous B6C3F1 mouse liver tumors
-
Ray J. S., Harbison M. L., McClain R. M., Goodman J. I. Alterations in the methylation status and expression of the raf oncogene in phenobarbital-induced and spontaneous B6C3F1 mouse liver tumors. Mol. Carcinogen. 9:1994;155-166.
-
(1994)
Mol. Carcinogen.
, vol.9
, pp. 155-166
-
-
Ray, J.S.1
Harbison, M.L.2
McClain, R.M.3
Goodman, J.I.4
-
42
-
-
0024515167
-
In vitro metabolism of methylene chloride in human and animal tissues: Use in physiologically based pharmacokinetic models
-
Reitz R. H., Mendrala A. L., Guengerich F. P. In vitro metabolism of methylene chloride in human and animal tissues: Use in physiologically based pharmacokinetic models. Toxicol. Appl. Pharmacol. 97:1989;230-246.
-
(1989)
Toxicol. Appl. Pharmacol.
, vol.97
, pp. 230-246
-
-
Reitz, R.H.1
Mendrala, A.L.2
Guengerich, F.P.3
-
43
-
-
0023556364
-
A review of the mutagenicity of chloroform
-
Rosenthal S. L. A review of the mutagenicity of chloroform. Environ. Mol. Mutagen. 10:1987;211-226.
-
(1987)
Environ. Mol. Mutagen.
, vol.10
, pp. 211-226
-
-
Rosenthal, S.L.1
-
44
-
-
0029451066
-
The use of biological data in addition to the carcinogen bioassay in quantitative risk assessment
-
R. M. McClainT. J. SlagaR. A. LeBoeufH. C. Pitot, Wiley, New York
-
R. J. Scheuplein, 1995, The use of biological data in addition to the carcinogen bioassay in quantitative risk assessment, Growth Factors and Tumor Promotion: Implications for Risk Assessment, R. M. McClainT. J. SlagaR. A. LeBoeufH. C. Pitot, 347, 358, Wiley, New York.
-
(1995)
Growth Factors and Tumor Promotion: Implications for Risk Assessment
, pp. 347
-
-
Scheuplein, R.J.1
-
49
-
-
85030295061
-
-
EPA/625/3-89-015, U. S. Environmental Protection Agency, Washington, DC
-
U.S. EPA, 1989a, Workshop on EPA guidelines for Carcinogen Risk Assessment, EPA/625/3-89-015, U. S. Environmental Protection Agency, Washington, DC.
-
(1989)
Workshop on EPA Guidelines for Carcinogen Risk Assessment
-
-
-
51
-
-
0011151312
-
-
EPA/600/9-91/050, U. S. Environmental Protection Agency, Washington, DC
-
U.S. EPA, 1992, Safeguarding the Future: Credible Science, Credible Decisions, EPA/600/9-91/050, U. S. Environmental Protection Agency, Washington, DC.
-
(1992)
Safeguarding the Future: Credible Science, Credible Decisions
-
-
-
53
-
-
0000060569
-
-
Fed. Reg. 61:1996;17960-18011.
-
(1996)
Fed. Reg.
, vol.61
, pp. 17960-18011
-
-
-
54
-
-
0025951624
-
Hypomethylation of ras oncogenes in chemically induced and spontaneous B6C3F1 mouse liver tumors
-
Vorce R. L., Goodman J. I. Hypomethylation of ras oncogenes in chemically induced and spontaneous B6C3F1 mouse liver tumors. J. Toxicol. Environ. Health. 34:1991;367-384.
-
(1991)
J. Toxicol. Environ. Health
, vol.34
, pp. 367-384
-
-
Vorce, R.L.1
Goodman, J.I.2
-
55
-
-
0011104368
-
Hepatitis and nephrosis due to cough syrup containing chloroform
-
Wallace C. J. Hepatitis and nephrosis due to cough syrup containing chloroform. California Med. 73:1950;442.
-
(1950)
California Med.
, vol.73
, pp. 442
-
-
Wallace, C.J.1
-
56
-
-
0029455988
-
Mechanistic considerations in risk assessment for epigenetic tumor-promoting carcinogens
-
R.M. McClain, T.J. Slaga, R.A. LeBoeuf, & H.C. Pitot. New York: Wiley
-
Williams G. M., Whysner J. Mechanistic considerations in risk assessment for epigenetic tumor-promoting carcinogens. McClain R. M., Slaga T. J., LeBoeuf R. A., Pitot H. C. Receptor-Mediated Biological Processes: Implications for Evaluating Carcinogenesis. 1995;369-384 Wiley, New York.
-
(1995)
Receptor-Mediated Biological Processes: Implications for Evaluating Carcinogenesis
, pp. 369-384
-
-
Williams, G.M.1
Whysner, J.2
|