Neither endogenous nor inhaled nitric oxide influences the function of circulating platelets in healthy volunteers

Clinical Science

Volumn 97, Issue 3, 1999, Pages 345-353

  Albert, Johanna ^a   Hakan Wallen N ^a   Nailin, L I ^a   Frostell, Claes ^a   Hjemdahl, Paul ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Bleeding time; Flow cytometry; N(G) monomethyl L arginine; Nitric oxide; Platelet aggregation; Platelet secretion

Indexed keywords

ANTITHROMBIN; BETA THROMBOGLOBULIN; CYCLIC GMP; FIBRINOGEN; N(G) METHYLARGININE; NITRIC OXIDE; PADGEM PROTEIN; THROMBIN;

ADULT; ARTICLE; BLEEDING TIME; BLOOD PRESSURE; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FLOW CYTOMETRY; HEART RATE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYSTOLIC BLOOD PRESSURE; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTE FUNCTION;

ADULT; BLEEDING TIME; BLOOD PLATELETS; CROSS-OVER STUDIES; CYCLIC GMP; DOUBLE-BLIND METHOD; ENZYME INHIBITORS; FLOW CYTOMETRY; HEMODYNAMIC PROCESSES; HUMANS; LEUKOCYTE COUNT; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; PLATELET COUNT; THROMBIN;

EID: 0032861420     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS19990064     Document Type: Article

References (43)

1. Palmer, R. M. J., Ferrige, A. G. and Moncada, S. (1987) Nitric oxide release accounts for biological activity of endothelium-derived relaxing factor. Nature (London) 327, 524-526
2. Ignarro, L. J. (1989) Endothelium-derived nitric oxide: action and properties. FASEB J. 3, 31-36
3. Radomski, M. W., Palmer, R. M. J. and Moncada, S. (1987) Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet ii, 1057-1058
4. You, S. K., Ober, J., Krishnaswami, A. et al. (1992) Endogenous nitric oxide protects against platelet aggregation and cyclic flow variations in stenosed and endothelium-injured arteries. Circulation 86, 1302-1309
5. Yan, Z., Yokota, T., Zhang, W. and Hansson, G. (1996) Expression of inducible nitric oxide synthase inhibits platelet adhesion and restores blood flow in the injured artery. Circ. Res. 79, 38-44
6. Gries, A., Böttiger, B., Dörsam, J. et al. (1997) Inhaled nitric oxide inhibits platelet aggregation after pulmonary embolism in pigs. Anesthesiology 86, 387-393
7. Kelm, M. and Schrader, J. (1990) Control of coronary vascular tone by nitric oxide. Circ. Res. 66, 1561-1575
8. Stamler, J. S., Simon, D. I., Osborne, J. A. et al. (1992) S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. Proc. Natl. Acad. Sci. U.S.A. 89, 444-448
9. Karlberg, K. E., Torfgård, K., Ahlner, J. and Sylvén, R. (1992) Dose-dependent effect of intravenous nitroglycerin on platelet aggregation, and correlation with plasma glyceryl dinitrate concentration in healthy men. Am. J. Cardiol. 69, 802-805
10. Karlberg, K. E., Ahlner, J., Henriksson, P., Torfgård, K. and Sylvén, K. (1993) Effects of nitroglycerin on platelet aggregation beyond the effects of acerylsalicylic acid in healthy subjects. Am. J. Cardiol. 71, 361-364
11. Wallén, N. H., Andersson, A. and Hjemdahl, P. (1994) Effects of treatment with oral isosorbide dinitrate on platelet function in vivo; a double-blind placebo-controlled study in patients with stable angina pectoris. Br. J. Clin. Pharmacol. 38, 63-70
12. Langford, E. J., Brown, A. S., Wainwright, R. J. et al. (1994) Inhibition of platelet activity by S-nitrosoglutathione during coronary angioplasty. Lancet 344, 1458-1460
13. Langford, E. J., Parfitt, A., de Belder, A. J., Marrinan, M. T. and Martin, J. F. (1997) A study of platelet activation during human cardiopulmonary bypass and the effect of S-nitrosoglutathione. Thromb. Haemostasis 78, 1516-1519
14. Krejcy, K., Schmetterer, L., Kastner, J. et al. (1995) Role of nitric oxide in hemostatic system activation in vivo in humans. Arterioseler. Thromb. Vasc. Biol. 15, 2063-2067
15. Samama, C. M., Diaby, M., Fellahi, J. L. et al. (1995) Inhibition of platelet aggregation by inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesthesiology 83, 56-65
16. Albert, J., Wallén, N. H., Bröijersén, A., Frostell, C. and Hjemdahl, P. (1996) Effects of inhaled nitric oxide compared with aspirin on platelet function in vivo in healthy subjects. Clin. Sci. 91, 225-231
17. Cheung, P., Salas, E., Peliowski, A., Etches, P., Schulz, R. and Radomski, M. (1997) Inhaled nitric oxide (NO) inhibits platelet aggregation in critically ill neonates. Pediatr. Res. 41, 143A (abstract 843)
18. Christou, H., Magnani, B., Morse, D. et al. (1997) Inhaled nitric oxide does not inhibit platelet activation in infants with persistent pulmonary hypertension of newborn (PPHN). Pediatr. Res. 41, 143A (abstract 844)
19. Gries, A., Bode, C., Peter, K. et al. (1998) Inhaled nitric oxide inhibits human platelet aggregation, P-selectin expression, and fibrinogen binding in vitro and in vivo. Circulation 97, 1481-1487
20. Bodzenta-Lukaszyk, A., Gabryelewicz, A., Lukaszyk, A., Bielawiec, M., Konturek, J. W. and Domschke, W. (1994) Nitric oxide synthase inhibition and platelet function. Thromb. Res. 75, 667-672
21. Simon, D., Stamler, J., Loh, E., Loscalzo, J., Francis, S. and Creager, M. (1995) Effect of nitric oxide synthase inhibition on bleeding time in humans. J. Cardiovasc. Pharmacol. 26, 339-342
22. Hjemdahl, P., Larsson, P. T. and Wallén, N. H. (1991) Effects of stress and beta-blockade on platelet function. Circulation 84 (suppl. VI), VI-44-VI-61
23. Joannidis, M., Buratti, T., Pechlaner, C. and Wiedermann, C. (1993) Letter (untitled). Lancet 348, 1448-1449
24. Högman, M., Frostell, C., Arnberg, H. and Hedenstierna, G. (1993) Bleeding time prolongation and NO inhalation. Lancet 341, 1664-1665
25. Albert, J., Schedin, U., Lindqvist, M., Melcher, A., Hjemdahl, P. and Frostell, C. (1997) Blockade of endogenous nitric oxide production results in moderate hypertension, reduced sympathetic activity and shortening of bleeding time in healthy volunteers. Acta Anaesthesiol. Scand. 41, 1101-1113
26. Janes, S., Wilson, D., Chronos, N. and Goodall, A. (1993) Evaluation of whole blood cytometric detection of platelet bound fibrinogen in normal subjects and patients with activated platelets. Thromb. Haemostasis 70, 659-666
27. Shattil, S., Cunningham, M. and Hoxie, J. (1987) Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry. Blood 70, 307-315
28. Warkentin, T., Powling, M. and Hardisty, R. (1990) Measurements of fibrinogen binding to platelets in whole blood by flow cytometry: a micromethod for detection of platelet activation. Br. J. Haematol. 76, 387-394
29. Michelson, A. (1996) Flow cytometry: a clinical test of platelet function. Blood 87, 4925-4936
30. Hornstra, G. and ten Hoor, F. (1975) The filtragomcter; a new device for measuring platelet aggregation in venous blood of man. Thromb. Diath, Haemorrh. 34, 531-544
31. Larsson, P. T., Hjemdahl, P., Olsson, G., Egberg, N. and Hornstra, G. (1989) Altered platelet function during mental stress and adrenaline infusions: evidence for an increased aggregability in vivo as measured by filtragometry. Clin. Sci. 76, 369-376
32. Larsson, P. T., Wallén, N. H. and Hjemdahl, P. (1994) Norepinephrine-induced human platelet activation in vivo is only partly counteracted by aspirin. Circulation 89, 1951-1957
33. Hjemdahl, P., Perneby, K., Egberg, N. and Larsson, P. T. (1991) A new assay for β-thromboglobulin in urine. Thromb. Res. 64, 33-43
34. Rångemark, C. and Wennmalm, Å. (1996) Smoke-derived nitric oxide and vascular prostacyclin are unable to counteract the platelet effect of increased thromboxane formation in healthy female smokers. Clin. Physiol. 16, 301-315
35. De Caterina, R., Lanza, M., Manca, G., Strata, G. B., Maffei, S. and Salvatore, L. (1994) Bleeding time and bleeding: an analysis of the relationship of the bleeding time test with parameters of surgical bleeding. Blood 84, 3363-3370
36. Radomski, M. W., Palmer, R. M. J. and Moncada, S. (1987) The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochem. Biophys. Res. Commun. 148, 1482-1489
37. Moro, M., Russell, R., Cellek, S. et al. (1996) cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase. Proc. Natl. Acad. Sci. U.S.A. 93, 1480-1485
38. Golino, P., Cappelli-Bigazzi, M., Ambrosio, G. et al. (1992) Endothelium-derived relaxing factor modulates platelet aggregation in an in vivo model of recurrent platelet activation. Circ. Res. 71, 1447-1456
39. Radomski, M., Palmer, R. and Moncada, S. (1987) The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br. J. Pharmacol. 92, 639-646
40. Radomski, M. W., Palmer, R. M. and Moncada, S. (1990) An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc. Natl. Acad. Sci. U.S.A. 87, 5193-5197
41. Wallén, N. H., Held, C., Rehnqvist, N. and Hjemdahl, P. (1995) Platelet aggregability in vivo is attenuated by verapamil hut not by metoprolol in patients with stable angina pectoris. Am J. Cardiol. 75, 1-6
42. Hjemdahl, P., Chronos, N., Wilson, D., Bouloux, P. and Goodall, A. (1994) Epinephrine sensitizes human platelets in vivo and in vitro as studied by fibrinogen binding and P-selectin expression. Arterioscler. Thromb. 14, 77-84
43. Söderbäck, U., Sollevi, A., Wallén, N. H., Larsson, P. T. and Hjemdahl, P. (1991) Anti-aggregatory effects of physiological adenosine concentrations in human whole blood as assessed by filtragometry. Clin. Sci. 81, 691-694