Biomarkers of dose and susceptibility in cyclists exposed to monoaromatic hydrocarbons

Toxicology Letters

Volumn 108, Issue 2-3, 1999, Pages 241-247

  Bergamaschi, Enrico ^a   Brustolin, Angelita ^a   De Palma, Giuseppe ^a   Manini, Paola ^a   Mozzoni, Paola ^a   Andreoli, Roberta ^a   Cavazzini, Stefania ^a   Mutti, Antonio ^a  

^a UNIVERSITY OF PARMA MEDICAL SCHOOL   (Italy)

Author keywords

Air pollution; Aromatic hydrocarbons; Benzene metabolism; Epoxide hydrolase; Glutathione S transferase class 1

Indexed keywords

AROMATIC HYDROCARBON; BENZENE; BIOLOGICAL MARKER; DNA; EPOXIDE HYDROLASE; ETHYLBENZENE; GLUTATHIONE TRANSFERASE; MUCONIC ACID; TOLUENE; XYLENE;

ADULT; AIR POLLUTION; ARTICLE; CYCLING; FEMALE; GAS CHROMATOGRAPHY; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MASS SPECTROMETRY; METABOLISM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOLID PHASE EXTRACTION;

ADULT; AIR POLLUTANTS; BENZENE; BENZENE DERIVATIVES; BICYCLING; BIOLOGICAL MARKERS; ENVIRONMENTAL MONITORING; FEMALE; HUMANS; HYDROCARBONS, AROMATIC; MALE; RURAL HEALTH; SEX FACTORS; SORBIC ACID; TOLUENE; URBAN HEALTH; XYLENES;

EID: 0032860348     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(99)00095-8     Document Type: Article

References (15)

1. Advice of the Italian Advisory Board Committee on Toxicology (CCTN) on the health risk assessment relative to exposure to automobile emissions, 1998. In: Camoni, I., Mucci, N., Foà, V. (Eds.). Istituto Superiore di Sanità, Rome.
2. Angerer J., Schrer G., Shaller K., Muller J. The determination of benzene in human blood as indicator of environmental exposure to volatile aromatic compounds. Fresenius J. Anal. Chem. 339:1991;740-742.
3. Arand M., Muhlbauer R., Hengstler J., Jager E., Fuchs J., Winkler R., Oesch F. A multiplex polymerase chain reaction protocol for the simultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 polymorphism. Anal. Biochem. 236:1996;184-186.
4. Bevan M.A.Y., Proctor C.J., Baker-Rogers J., Warren N.D. Exposure to carbon monoxide, respirable suspended particulates and volatile organic compounds while commuting by bicycle. Environ. Sci. Technol. 25:1991;788-791.
5. Boogard P.J, van Sittern N.J. Suitability of S-phenyl mercapturic acid and trans, trans-muconic acid as biomarkers for exposure to low concentrations of benzene. Environ. Health Perspect. 104:1996;1151-1157.
6. Brown E.A., Shelley M.L., Fisher J.W. A pharmacokinetic study of occupational and environmental benzene exposure with regard to gender. Risk Anal. 18:1998;205-213.
7. Buratti, M., Pellegrino, O., Valla, C., Fustinoni, S., Colombi, A., 1997. Monitoraggio biologico dell'esposizione ambientale a benzene in addetti alla vigilanza urbana. Med. Lav. 88, 208-219, (in Italian).
8. Ducos P., Gaudin R., Bel J., Maire C., Francin J.M., Robert A., Wild P. t,t-Muconic acid, a reliable biological indicator for the detection of individual benzene exposition down to the ppm level. Int. Arch. Occup. Environ. Health. 64:1992;309-313.
9. Fustinoni S., Buratti M., Giampiccolo R., Colombi A. Biological and environmental monitoring of exposure to airborne benzene and other aromatic hydrocarbons in Milan traffic wardens. Toxicol. Lett. 77:1995;387-392.
10. Gobba F., Rovesti S., Borella P., Vivoli R., Caselgrandi E., Vivoli G. Inter-individual variability of benzene metabolism to trans,trans-muconic acid and its implications in the biological monitoring of occupational exposure. Sci. Total Environ. 199:1997;41-48.
11. Hassett C., Aicher L., Sidhu J.S., Omiecinsky C.J. Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants. Hum. Mol. Genet. 3:1994;421-428.
12. Hotz P., Carbonnelle P., Haufroid V., Tschopp A., Lauwerys R. Biological monitoring of vehicle mechanics and other workers exposed to low concentrations of benzene. Int. Arch. Occup. Environ. Health. 70:1997;29-40.
13. Priante, E., Schiavon, G., Gori G., Bartolucci, G.B., Soave, C., Brugnone, F., Clonfero, E., 1996. Esposizione agli inquinanti dell'aria urbana dei vigili municipali. Med. Lav. 87, 314-322, (in Italian).
14. Smith C.A.D., Harrison D.J. Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema. Lancet. 350:1997;630-633.
15. van Wijnen J.H., Verhoeff A.P., Jans H.W.A., van Bruggen M. The exposure of ciclysts, car drivers and pedestrians to traffic-related air pollutants. Int. Arch. Occup. Environ. Health. 67:1995;187-193.