Oral use of interferon-α stimulates ISG-15 transcription and production by human buccal epithelial cells

Journal of Interferon and Cytokine Research

Volumn 19, Issue 8, 1999, Pages 923-928

  Smith, J Kelly ^a   Siddiqui, Afzal A ^a   Krishnaswamy, Guha A ^a   Dykes, Rhesa ^a   Berk, Steven L ^a   Magee, Mike ^a   Joyner, William ^a   Cummins, Joseph ^a  

^a East Tennessee State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; INTERFERON; LYMPHOBLAST INTERFERON;

ARTICLE; CHEEK MUCOSA; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; EPITHELIUM CELL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOMODULATION; MOUTH MUCOSA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, ORAL; CELL DIVISION; CHEEK; CYTOKINES; EPITHELIAL CELLS; HUMANS; INTERFERON-ALPHA; KILLER CELLS, NATURAL; MOLECULAR WEIGHT; MOUTH MUCOSA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STIMULATION, CHEMICAL; TRANSCRIPTION, GENETIC; UBIQUITINS;

EID: 0032858712     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/107999099313460     Document Type: Article

References (27)

1. CUMMINS, J.M., HUTCHESON, D.P., CUMMINS, M.J., GEORGIADES, J.A., and RICHARDS, A.B. (1993). Oral therapy with human interferon alpha in calves experimentally infected with infectious bovine rhinotracheitis virus. Arch. Immunol. Ther. Exp. 41, 193-197.
2. LECCE, J.G., CUMMINS, J.M., and RICHARDS, A.B. (1990). Treatment of rotavirus infection in newborn pigs using natural human interferon alpha. Mol. Biother. 2, 211-216.
3. SCHAFER, T.W., LIEBERMAN, M., COHEN, M., and CANE, P. (1972). Interferon administration orally: protection of neonatal mice from lethal virus challenge. Science 176, 1326-1327.
4. BABIUCH, L., MIAN, M., KAMINSKA, E., SZYMANSKA, B., and GEORGIADES, J.A. (1993). An interim report on the effect of natural human interferon alpha (IFNα) lozenges in patients seropositive for the human immunodeficiency virus type 1 (HIV-1). Arch. Immunol. Ther. Exp. 41, 213-219.
5. HULTON, M., LEVIN, D., and FREEDMAN, L. (1992). Randomized, placebo-controlled, double-blind study of low dose oral interferon-α in HIV-1 antibody positive patients. J. AIDS 5, 1084-1090.
6. KAISER, G., JAEGER, H., BIRKMAN, J., POPPINGER, J., CUMMINS, J., and GALLMEIER, W. (1992). Low-dose oral natural interferon-α in 29 patients with HIV-1 infection: a double-blind, randomized, placebo-controlled trial. AIDS 6, 563-569.
7. WEISS, R.C., CUMMINS, J.M., and RICHARDS, A.B. (1991). Low dose orally administered alpha interferon treatment for feline leukemia virus infection. J. Am. Vet. Med. Assoc. 199,1477-1481.
8. CABAN, J., MOSSOR-OSTROWSKA, J., ZYRKOWSKA-BIEDA, T., ZEJC, M., JANAS-SKULINA, U., CIESLA, A., CUMMINS, J.M., and GEORGIADES, J.A. (1993). Treatment of chronic viral hepatitis type B with oral mucosal administration of natural human interferon alpha lozenges. Arch. Immunol. Ther. Exp. 41, 229-235.
9. GEORGIADES, J.A. (1996). Natural human interferon α may act differently when given parenterally or orally to patients chronically infected with hepatitis B virus. Arch. Immunol. Ther. Exp. (Warsz) 44, 11-22.
10. ZIELINSKA, W., PASZKIEWICZ, J., KORCZAK, A., WLASIUK, M., ZOLTOWSKA, A., SZUTOWICZ, A., CUMMINS, J.M., and GEORGIADES, J.A. (1993). Treatment of fourteen chronic active HBsAg +, HBeAg+ hepatitis patients with low dose natural human interferon alpha administered orally. Arch. Immunol. Ther. Exp. (Warsz) 41, 241-251.
11. SHIOZAWA, S., TANAKA, Y., and SHIOZAWA, K. Single-blinded controlled trial of low dose oral interferon-alpha for the treatment of xerostomia in Sjogren's syndrome patients, unpublished data.
12. BROD, S.A., and KHAN, M. (1996). Oral administration of IFN-alpha is superior to subcutaneous administration of IFN-alpha in the suppression of chronic relapsing experimental autoimmune encephalomyelitis. J. Autoimmun. 9, 11-12.
13. BROD, S.A., KERMAN, R.H., NELSON, L.D., MARSHALL, G.D. Jr., HENNINGER, E.M., KHAN, M., JIN, R., and WOLINSKY, J.S. (1997). Ingested IFN-alpha has biological effects in humans with relapsing-remitting multiple sclerosis. Multiple Sclerosis 3, 1-7.
14. FLEISCHMANN, W.R. Jr., MASOOR, J., WU, T.Y., and FLEISCHMANN, C.M. (1998). Orally administered IFN-alpha acts alone and in synergistic combination with intraperitoneally administered IFN-gamma to exert an antitumor effect against B16 melanoma in mice. J. Interferon Cytokine Res. 18, 17-20.
15. SMITH, J.K., CHI, D.S., KRISHNASWAMY, G., SRIKANTH, S., REYNOLDS, S., and BERK, S.L. (1996). Effect of interferon α on HLA-DR expression by human buccal epithelial cells. Arch. Immunol. Ther. Exper. (Warsz) 41, 83-87.
16. DAO, T., TAKEUCHI, M., FUKUDA, S., and KURIMOTO, M. (1995). Natural human interferon-alpha enhances the expression of intracellular adhesion molecule molecule-1, integrin alpha-2 and beta 1 by a mucosal epithelial cell line. Folia Biol (Praha). 41, 213-225.
17. D'CUNHA, J., KNIGHT, E. Jr., HAAS, A.L., TRUITT, R.L., and BORDEN, E.C. (1996). Immunoregulatory properties of ISG-15, and interferon-induced cytokine. Proc. Natl. Acad. Sci. USA 93, 211-215.
18. LOEB, K.R., and HAAS, A.L. (1992). The interferon-inducible 15-kDa Ubiquitin homolog conjugates to intracellular proteins. J. Biol. Chem. 267, 7806-7813.
19. HUANG, S-K., ESSAYAN, D., KRISHNASWAMY, G., YI, M., SU, S., XIAO, H., and LIU, M. (1994). Detection of allergen and mitogen-induced human cytokine transcripts using a competitive polymerase chain reaction. J. Immunol. Methods 168, 167-181.
20. ALTSCHUL, S.F., GISH, W., MILLER, W., MYERS, E.W., and LIPMAN, D.J. (1990). Basic local alignment search tool. J. Mol. Biol. 215, 403-410.
21. LAEMMLI, U.K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
22. SIDDIQUI, A.A., PODESTA, R.B., and CLARKE, M.W. (1991). Schistosoama mansoni: Characterization and identification of calcium-binding proteins associated with the apical plasma membrane and envelope. Expt. Parasitol. 72, 63-68.
23. DAWSON, M.M. (1991). Interferon gamma. In: Lymphokines and Interleukins. M.M. Dawson (ed.) Boca Raton, FL: CRC Press, pp. 190-209.
24. ROOK, G. (1993). Immunity to viruses, bacteria and fungi. In: Immunology, 3rd ed. I.M. Roitt, J. Brostoff, and D.K. Male (eds.) Philadelphia: J.B. Lippincott Co., pp. 16.5-16.6.
25. GUTTERMAN, J.U. (1994). Cytokine therapeutics: lessons from interferon α. Proc. Natl. Acad. Sci. USA 91, 1198-1205.
26. PARRONCHI, P., DE CARTI, M., MANETTI, R., SIMONELLI, C., SAMPOGNARO, S., PICCINNI, M.-P., MACCHIA, D., MAGGI, E., DEL PRETE, G., and ROMAGNANI, S. (1992). IL-4 and IFN αa and γ) exert opposite regulatory effects on the development of cytotoxic potential by Th1 or Th2 human T cell clones. J. Immunol. 149, 2977-2983.
27. H2 responses: a key role for the "natural" immune response? Immunol. Today 13, 379-381.