Differential effects of clonidine on upper airway abductor and adductor muscle activity in awake goats

Journal of Applied Physiology

Volumn 87, Issue 2, 1999, Pages 590-597

  O'Halloran, K D ^a   Herman, J K ^a   Bisgard, G E ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Apnea; Electromyogram; Laryngeal muscles; Pharyngeal muscles; 2 adrenoceptor

Indexed keywords

6 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 1H 3 BENZAZEPINE; CLONIDINE;

AIRWAY OBSTRUCTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL OXYGEN TENSION; ARTICLE; BREATHING MUSCLE; ELECTROMYOGRAM; GOAT; MUSCLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; RESPIRATION DEPRESSION; TACHYPNEA;

EID: 0032858614     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1999.87.2.590     Document Type: Article

References (43)

1. Andrade, R., and G. K. Aghajanian. Single cell activity in the noradrenergic A5 region: responses to drugs and peripheral manipulations of blood pressure. Brain Res. 242: 125-135, 1982.
2. 2-adrenoceptor-induced hyperpolarization of locus ceruleus neurons in brain slices: reversal by cyclic adenosine 3′,5′-monophosphate analogues. J. Neurosci. 5: 2359-2364, 1985.
3. 2 adrenoceptors in the central nervous system. In: The Pharmacology of Noradrenaline in the Central Nervous System, edited by D. J. Heal and C. A. Marsden. New York: Oxford Univ. Press, 1990, p. 141-154.
4. Arita, H., and M. Ochiishi. Opposing effects of 5-hydroxytryptamine on two types of medullary inspiratory neurons with distinct firing patterns. J. Neurophysiol. 66: 285-292, 1991.
5. Badr, M. S., F. Toiber, J. B. Skatrud, and J. A. Dempsey. Pharyngeal narrowing/occlusion during central sleep apnea. J. Appl. Physiol. 78: 1806-1815, 1995.
6. 2-adrenergic agonist clonidine and its antagonist idazoxan on the fetal lamb. J. Physiol. (Lond.) 381: 29-37, 1986.
7. 2-adrenergic antagonist on fetal lambs: a possible mechanism for hypoxic apnea. J. Dev. Physiol. (Eynsham) 13: 353-358, 1990.
8. Barillot, J. C., and M. Dussardier. Activité des motoneurones larygés expiratoires. J. Physiol. Paris 72: 311-343, 1976.
9. Bianconi, R., and F. Raschi. Respiratory control of motoneurons of the recurrent laryngeal nerve and hypocapnic apnea. Arch. Ital. Biol. 102: 56-73, 1964.
10. Champagnat, J., M. Denavit-Saubié, J. L. Henry, and V. Leviel. Catecholaminergic depressant effects on bulbar respiratory mechanisms. Brain Res. 160: 57-68, 1979.
11. Ellenberger, H. H., and J. L. Feldman. Subnuclear organization of the lateral tegmental field of the rat. I: Nucleus ambiguus and ventral respiratory group. J. Comp. Neurol. 294: 202-211, 1990.
12. 2-adrenoceptors in solitary tract nucleus. Am. J. Physiol. 254 (Heart Circ. Physiol. 23): H756-H762, 1988.
13. Frugière, A., and J. C. Barillot. Respiratory-related activity of the pharyngeal nerves in the rat. Respir. Physiol. 98: 295-304, 1994.
14. Fukuda, A., T. Minami, J. Nabekura, and Y. Oomura. The effects of noradrenaline on neurones in the rat dorsal motor nucleus of the vagus, in vitro. J. Physiol. (Lond.) 393: 213-231, 1987.
15. Grélot, L., J. C. Barillot, and A. L. Bianchi. Pharyngeal motoneurones: respiratory-related activity and responses to laryngeal afferents in the decerebrate cat. Exp. Brain Res. 78: 336-344, 1989.
16. Guyenet, P. G., N. Koshiya, D. Huangfu, A. J. M. Verberne, and T. A. Riley. Central respiratory control of A5 and A6 pontine noradrenergic neurons. Am. J. Physiol. 264 (Regulatory Integrative Comp. Physiol. 33): R1035-R1044, 1993.
17. 2A-adrenergic receptors are present in lower brainstem catecholaminergic and serotonergic neurons innervating spinal cord. Brain Res. 638: 285-294, 1994.
18. Harding, R., P. Johnson, and M. E. McClelland. Respiratory function of the larynx in developing sheep and the influence of sleep state. Respir. Physiol. 40: 165-179, 1980.
19. Hedrick, M. S., M. R. Dwinell, P. L. Janssen, J. Pizarro, and G. E. Bisgard. Differential respiratory muscle recruitment induced by clonidine in awake goats. J. Appl. Physiol. 84: 1198-1207, 1998.
20. 2 adrenergic agonists in goats. Respir. Physiol. 101: 128-137, 1995.
21. 2-adrenoceptors in awake and anesthetized goats. J. Appl. Physiol. 77: 742-750, 1994.
22. Insalaco, G., S. T. Kuna, G. Catania, O. Marrone, B. M. Costanza, V. Bellia, and G. Bonsignore. Thyroarytenoid muscle activity in sleep apneas. J. Appl. Physiol. 74: 704-709, 1993.
23. Kawasaki, M., J. H. Ogura, and S. Takenouchi. Neurophysiologic observations of normal deglutition. I. Its relationship to the respiratory cycle. Laryngoscope 74: 1747-1765, 1964.
24. Kianicka, I., V. Diaz, D. Dorion, and J.-P. Praud. Coordination between glottic adductor muscle and diaphragm EMG activity in fetal lambs in utero. J. Appl. Physiol. 84: 1560-1565, 1998.
25. Kianicka, I., J. Leroux, and J.-P. Praud. Thyroarytenoid muscle activity during hypocapnic central apneas in awake nonsedated lambs. J. Appl. Physiol. 76: 1262-1268, 1994.
26. Kuna, S. T., M. P. McCarthy, and J. S. Smickley. Laryngeal response to passively induced hypocapnia during NREM sleep in normal adult humans. J. Appl. Physiol. 75: 1088-1096, 1993.
27. Kuna, S. T., and J. S. Smickley. Superior pharyngeal constrictor activation in obstructive sleep apnea. Am. J. Respir. Crit. Care Med. 156: 874-880, 1997.
28. Kuna, S. T., and C. R. Vanoye. Respiratory-related pharyngeal constrictor muscle activity in decerebrate cats. J. Appl. Physiol. 83: 1588-1594, 1997.
29. Lavoie, J. P., J. R. Pascoe, and C. J. Kurpershoek. Effects of xylazine on ventilation in horses. Am. J. Vet. Res. 53: 916-920, 1992.
30. Nicholas, A. P., V. Pieribone, and T. Hokfelt. Distribution of alpha-2 adrenergic receptor subtypes in rat brain: an in situ hybridization study. J. Comp. Neurol. 328: 575-594, 1993.
31. Nichols, A. J. α-Adrenoceptor signal transduction mechanisms. In: α-Adrenoceptors: Molecular Biology, Biochemistry and Pharmacology, edited by R. R. Ruffolo, Jr. Basel: Karger, 1991, vol. 8, p. 44-74. (Prog. Basic Clin. Pharmacol. Ser)
32. h) in rat hypoglossal motoneurons. Brain Res. 769: 108-118, 1997.
33. Pilowsky, P. M., C. Jiang, and J. Lipski. An intracellular study of respiratory neurons in the rostral ventrolateral medulla of the rat and their relationship to catecholamine-containing neurons. J. Comp. Neurol. 301: 604-617, 1990.
34. Praud, J., I. Kianicka, V. Diaz, J. Leroux, and D. Dalle. Prolonged active glottic closure after barbiturate-induced respiratory arrest in lambs. Respir. Physiol. 104: 221-229, 1996.
35. 2C-adrenergic receptor-like immunoreactivity in the rat central nervous system. J. Comp. Neurol. 372: 135-165, 1996.
36. 2-adrenoceptor subtypes. Annu. Rev. Pharmacol. Toxicol. 32: 243-279, 1993.
37. Ruggins, N. R., and A. D. Milner. Site of upper airway obstruction in preterm infants with problematical apnoea. Arch. Dis. Child. 66: 787-792, 1991.
38. Saxon, D. W., G. N. Robertson, and D. A. Hopkins. Ultrastructure and synaptology of the nucleus ambiguus in the rat: the semicompact and loose formations. J. Comp. Neurol. 375: 109-127, 1996.
39. Sherrey, J. H., and D. Megirian. Spontaneous and reflexly evoked activity in pharyngeal, laryngeal, and phrenic motoneurons of cat. Exp. Neurol. 42: 17-27, 1974.
40. Sherrey, J. H., and D. Megirian. Analysis of the respiratory role of pharyngeal constrictor motoneurons of cat. Exp. Neurol. 49: 839-851, 1975.
41. Sherrey, J. H., M. J. Pollard, and D. Megirian. Respiratory functions of the inferior pharyngeal constrictor and sternohyoid muscles during sleep. Exp. Neurol. 92: 267-277, 1986.
42. Smith, C. A., M. J. A. Engwall, J. A. Dempsey, and G. E. Bisgard. Effects of specific carotid body and brain hypoxia on respiratory muscle control in the awake goat. J. Physiol. (Lond.) 460: 623-640, 1993.
43. 2A-adrenergic receptor-like immunoreactivity in the rat central nervous system. J. Comp. Neurol. 372: 111-134, 1996.