Peroral polypeptide delivery: A comparative in vitro study of mucolytic agents

Arzneimittel-Forschung/Drug Research

Volumn 49, Issue 9, 1999, Pages 799-803

  Bernkop Schnürch, Andreas ^a   Valenta, Claudia ^a   Daee, Seyed Mansour ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Detergents; Diffusion barrier; Mucolytic agents; Mucus layer; Proteases; Sulfhydryl compounds

Indexed keywords

ACETYLCYSTEINE; MUCOLYTIC AGENT; POLYSORBATE 20; THIOL DERIVATIVE; TRITON X 100;

ARTICLE; BIOAVAILABILITY; BRONCHUS MUCUS; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG MECHANISM; ENZYME DEGRADATION; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; MUCOLYSIS; PEPTIDE SYNTHESIS; PROTEIN DEGRADATION;

EID: 0032858565     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300504     Document Type: Article

References (19)

1. Zhou, X. H., Overcoming enzymatic and absorption harriers to non-parenterally administered protein and peptide drugs. J. Control. Release 29, 239 (1994)
2. Woodley, J. F., Enzymatic Barriers for GI Peptide and Protein Delivery. Crit. Rev. Ther. Drug. 11, 61 (1994)
3. Bernkop-Schnürch, A., The use of inhibitory agents to overcome the enyzmatic barrier to perorally administered therapeutic peptides and proteins. J. Control. Release 52, 1 (1998)
4. Allen, A., Bell, A., Mantle, M. et al., in: Mucus Medicine and Biology, E. N. Elder, J. B. Elstein (eds.), p. 115, Vol 144, Plenum Press, New York (1982)
5. Bernkop-Schnürch, A., Frugner, R. Investigations into the Difussion Behaviour of Polypeptides in Native Intestinal Mucus with Regard to their Peroral Administration. Pharm. Sci. 2, 361 (1996)
6. Iiboshi, Y., Nezu, R., Khan, J. et al., Developmental changes in distribution of the mucous gel layer and intestinal permeability in rat small intestine. J. Parenter. Enteral. Nutr. 20, 406 (1996)
7. Allen, A., in: Physiology of the Gastrointestinal Tract, L. R. Johnson (ed.), p. 617, Raven Press, New York (1981)
8. Matthes, I., Nimmerfall, F., Sucker, H., Mucusmodelle zur Untersuchung von intestinalen Absorptionsmechanismen. Pharmazie, 47, 505 (1992)
9. Coupe, A. J., Davis, S. S., Wilding, I. R., Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects. Pharm. Res., 8, 360 (1991)
10. Lehr. C.-M., Bioadhesion Technologies for the Delivery of Peptide and Protein Drugs to the Gastrointestinal Tract. Crit. Rev. Ther. Drug. 11, 119 (1994)
11. Karlson, P., Biochemie, Thieme, Verlag, Stuttgart, New York (1984)
12. Lieberman, J., Measurement of sputum viscosity in a cone-plate viscometer. Am. Rev. Respir. Dis. 97, 662 (1967)
13. Kerss, S., Allen, A., Garner, A., A simple method for measuring thickness of mucus gel layer adherent to rat, frog and human gastric mucosa: influence of feeding, prostaglandin, N-acetylcysteine and other agents. Clin. Sci. 63, 187 (1982)
14. Bristow, A. F., in: Polypeptide and Protein Drugs, R. C. Hider, D. Barlow (eds.). p. 54, Ellis Horwood, New York (1991)
15. Udod, V. M., Kolos, A. I., Gritsuliak, Z. N., Treatment of patients with lung abscess by local administration of papain. Vestn Khir 142, 24 (1989)
16. Chudnovskii, N. A., Use of the proteolytic enzyme papain in the treatment of cervical osteochondrosis. Zh. Vopr. Neirokhir 6, 43 (1985)
17. Sandbcrg, J. W. Lau, Ch., Jacomino, M. et al., Improving Access to Intestinal Stem Cells as a Step Toward Intestinal Gene Transfer. Human Gene Ther. 5, 323 (1994)
18. Corfield, A. P., Wagner, S. A., Odonell, L. J. D. et al., The roles of enteric bacterial sialidase, sialate O-acctyl esterase and glycosulfatase in the degradation of human colonie mucin. Glycoconjugate J. 10, 72 (1993)
19. Bernkop-Schnürch, A., Polymer-Inhibitor Conjugates: A Promising Strategy to Overcome the Enzymatic Barrier to Perorally Administered (Poly)Peptide Drugs? S.T.P. Pharma Sci. 9, 78 (1999)