Functional phage display of leech-derived tryptase inhibitor (LDTI): Construction of a library and selection of thrombin inhibitors

FEBS Letters

Volumn 458, Issue 1, 1999, Pages 11-16

  Tanaka, Aparecida S ^a,b   Silva, Melissa M ^a   Torquato, Ricardo J S ^a   Noguti, Maria A E ^a   Sampaio, Claudio A M ^a   Fritz, Hans ^b   Auerswald, Ennes A ^b  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Combinatorial library; Filamentous phage; Kazal type serine proteinase inhibitor; Phage display system; Thrombin inhibitor

Indexed keywords

BLOOD CLOTTING FACTOR 10A; ENZYME INHIBITOR; LEUKOCYTE ELASTASE; PLASMA KALLIKREIN; THROMBIN; THROMBIN INHIBITOR; TRYPSIN; TRYPTASE;

ARTICLE; BACTERIOPHAGE M13; BLOOD CLOTTING TIME; CONTROLLED STUDY; DNA LIBRARY; DRUG SPECIFICITY; ENZYME INHIBITION; GENE CONSTRUCT; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; INHALATIONAL DRUG ADMINISTRATION; LEECH; MUTATION; NORMAL HUMAN; PHAGEMID; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; BACTERIOPHAGES; BASE SEQUENCE; CHYMASES; CLONING, MOLECULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KINETICS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; PEPTIDE LIBRARY; PROTEINS; SACCHAROMYCES CEREVISIAE; SERINE ENDOPEPTIDASES; THROMBIN; TRYPTASES;

EID: 0032858094     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(99)01106-0     Document Type: Article

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