Structure-based design of a potent chimeric thrombin inhibitor

Journal of Biological Chemistry

Volumn 272, Issue 32, 1997, Pages 19938-19942

  Morenweiser, Robert ^a   Auerswald, Ennes A ^a   Van De Locht, Andreas ^b   Fritz, Hans ^a   Stürzebecher, Jörg ^c   Stubbs, Milton T ^a,b,d  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c Klinikum der Universitat Jena   (Germany)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 MACROGLOBULIN; FIBRINOGEN; GLYCOSAMINOGLYCAN; HIRUDIN; PROTEINASE; THROMBIN; THROMBIN INHIBITOR;

ARTICLE; BINDING AFFINITY; BLOOD CLOTTING; CARBOXY TERMINAL SEQUENCE; CHIMERA; ENZYME ACTIVATION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; CLONING, MOLECULAR; DRUG DESIGN; HUMANS; INSECT PROTEINS; LEECHES; MODELS, MOLECULAR; PROTEINS; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; SERINE PROTEINASE INHIBITORS; THROMBIN;

HIRUDINIDA;

EID: 0030753743     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.32.19938     Document Type: Article

References (43)

1. Stubbs, M. T., and Bode, W. (1995) Trends Biochem. Sci. 20, 23-28
2. Olson S. T., and Björk, I. (1992) in Thrombin: Structure and Function (Berliner, L. J., ed) pp. 159-217, Plenum Press, New York
3. Ascenzi, P., Coletta, M., Amiconi, G., de Cristofaro, R., Bolognesi, M., Guarneri, M., and Menegatti, E. (1988) Biochem. Blophys. Acta 956, 156-161
4. Bode, W., Mayr, I., Baumann, U., Huber, R., Stone, S. R., and Hofsteenge, J. (1989) EMBO J. 8, 3467-3475
5. Bode, W., Turk, D., and Karshikov, A. (1992) Protein Sci. 1, 426-471
6. Walsmann, P., and Markwardt, F. (1981) Pharmazie 36, 653-660
7. Rydel, T. J., Ravichandran, K. G., Tulinsky, A., Bode, W., Huber, R., Roitsch, C., Fenton, J. W., II (1990) Science 249, 277-280
8. Grütter, M. G., Priestle, J. P., Rahuel, J., Grossenbacher, H., Bode, W., Hofsteenge, J., and Stone, S. R. (1990) EMBO J. 9, 2361-2365
9. van de Locht, A., Lamba, D., Bauer, M., Huber, R., Friedrich, T., Kröger, B., Höffken, H. W., and Bode, W. (1995) EMBO J. 14, 5149-5157
10. Friedrich, T., Kröger, B., Biolajan, S., Lemaire, H. G., Höffken, H. W., Reuschenbach, P., Otte, M., and Dodt, J. (1993) J. Biol. Chem. 268, 16216-16222
11. van de Locht, A., Stubbs, M. T., Bode, W., Friedrich, T., Bollschweiler, C., Höffken, W., and Huber, R. EMBO J. 15, 6011-6017
12. Bode, W., and Huber, R. (1992) Eur. J. Biochem. 204, 433-452
13. Fink, E., Rehm, H., Gippner, C., Bode, W., Eulitz, M., Machleidt, W., and Fritz, H (1986) Biol. Chern. Hoppe-Seyler 367, 1235-1242
14. Sommerhoff, C. F., Söllner, C., Mentele, R., Piechottka, G. P., Auerswald, E. A., and Fritz, H. (1994) Biol. Chem. Hoppe-Seyler 375, 685-694
15. Mühlhahn, P., Czisch, M., Morenweiser, R., Habermann, B., Engh, R. A., Sommerhoff, C. P., Auerswald, E. A., and Holak, T. A. (1994) FEBS Lett. 355, 290-296
16. Stubbs, M. T., Morenweiser, R., Bauer, M., Bode, W., Huber, R., Piechottka, G. P., Matschiner, G., Sommerhoff, C. P., Fritz, H., and Auerswald, E. A. (1997) J. Biol. Chem. 272, 19931-19937
17. Auerswald, E. A., Morenweiser, R., Sommerhoff, C. P., Piechottka, G. P., Eckerskorn, C., Gürtler, L. G., and Fritz, H. (1994) Biol. Chem. Hoppe-Seyler 375, 695-703
18. Stubbs, M. T., and Bode, W. (1993) Thromb. Res. 69, 1-58
19. Stubbs, M. T., Oschkinat, H., Mayr, I., Huber, R., Angliker, H., Stone, S. R., and Bode, W. (1992) Eur. J. Biochem. 206, 187-195
20. Jones, T. A., Zou, J.-Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. Sec. A 47, 110-119
21. Becker, D. M., and Guarente, L. (1991) Methods Enzymol. 194, 182-187
22. Morrison, J. W. (1969) Biochim. Biophys. Acta 185, 269-286
23. Baici, A. (1981) Eur. J. Biochem. 119, 9-14
24. Chen, X.-M., Qian, Y.-W., Chi, C.-W., Gan, K.-D., Zhangh, M.-F., and Chen, C.-Q. (1992) J. Biochem. (Tokyo) 112, 45-51
25. Stephens, A. W., Thalley, B. S., and Hirs, C. H. W. (1987) J. Biol. Chem. 262, 1044-1048
26. Stephens, A. W., Siddiqui, A., and Hirs, C. H. W. (1988) J. Biol. Chem. 263, 15849-15852
27. Theunissen, H. J. M., Dijkema, R., Grootenhuis, P. D. J., Swinkels, J. C., de Poorter, T. L., Carati, P., and Visser, A. (1993) J. Biol. Chem. 268, 9035-9040
28. Johnson, D. J., Pemberton, S., Acquila, M., Mori, P. G., Tuddenham, E. G., and O'Brien, D. P. (1994) Thromb. Haemostasis 71, 428-433
29. Matthews, J. H., Krishnan, R., Costanzo, M. J., Maryanoff, B. E., and Tulinsky, A. (1996) Biophys. J. 71, 2830-2839
30. Schmitz, T., Rothe, M., and Dodt, J. (1991) Eur. J. Biochem. 195, 251-256
31. de Cristofaro, R., Rocca, B., Bizzi, B., and Landolfi, R. (1993) Biochem. J. 289, 475-80
32. Griffith, M. J., Noyes C. M., Tyndall, J. A., and Church, F. C. (1985) Biochemistry 24, 6777-6782
33. Ragg, H. (1986) Nucleic Acids Res. 14, 1073-1088
34. Van Deerlin, V. M. D., and Tollefsen, D. M. (1991) J. Biol. Chem. 266, 20223-20231
35. Ragg, H., Ulshofer, T., and Gerewitz, J. (1990) J. Biol. Chem. 265, 5211-5218
36. Rogers, S. J., Pratt, C. W., Whinna, H. C., and Church, F. C. (1992) J. Biol. Chem. 267, 3613-3617
37. Le Bonniec, B. F., and Esmon, C. T. (1991) Proc. Nat. Acad. Sci. U. S. A. 88, 7371-7375
38. Guinto, E. R., Ye, J., Le Bonniec, B., and Esmon, C. T. (1994) J. Biol. Chem. 269, 18395-18400
39. van de Locht, A., Bode, W., Huber, R., Le Bonniec, B. F., Stone, S. R., Esmon, C. T., and Stubbs, M. T. (1997) EMBO J. 16, 2977-2984
40. Maraganore, J. M., Bourdon, P., Jablonski, J., Ramachandran, K. L., and Fenton, J. W., II (1990) Biochemistry 29, 7095-7101
41. DiMaio, J., Gibbs, B., Munn, D., Lefebvre, J., Ni, F., and Konishi, Y. (1990) J. Biol. Chem. 265, 21698-21703
42. Kraulis, P. (1991) J. Appl. Crystallogr. 24, 946-950
43. Evans, S. V. (1992) J. Mol. Graphics 11, 134