Oral controlled release of melatonin using polymer-reinforced and coated alginate beads

International Journal of Pharmaceutics

Volumn 144, Issue 1, 1996, Pages 37-46

  Lee, Beom Jin ^a   Min, Geun Hong ^a  

^a Kangwon National University   (South Korea)

Author keywords

Alginate beads; Coated; Melatonin; Polymer reinforced; Release rate; SEM

Indexed keywords

ALGINIC ACID; ALUMINUM DERIVATIVE; EUDRAGIT RS; MELATONIN; PLASTICIZER; POLYMER;

ARTICLE; CONTROLLED RELEASE FORMULATION; DRUG RELEASE; INTESTINE FLUID; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; STOMACH JUICE;

EID: 0030598297     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(96)04723-0     Document Type: Article

References (17)

1. Benes, L., Brun, J., Claustrat, B., Degrande, G., Ducloux, N., Geoffriau, M., Horriere, F., Karsenty, H. and Lagain, D., Plasma melatonin (M) and Sulfatoxymelatonin (aMT6s) kinetics after transmucosal administration to humans. In Touitou, Y., Arendt, J. and Pévet, P. (Eds.) Melatonin and the pineal gland - from basic science to clinical application. Elsevier Science Publishers B.V., Amsterdam, The Netherlands, 1993, pp. 347-350.
2. Bodmeier, R. and Paeratakul, O. Spherical agglomerates of water-insoluble drugs. J. Pharm. Sci., 78 (1989) 964-967.
3. Hwang, S.-J., Rhee, G.J., Jo, H.B., Lee, K.M. and Kim, C.-K., Alginate beads as controlled release polymeric drug delivery system. J. Korean. Pharm. Sci., 23 (1993) 19-26.
4. Kim, C-K. and Lee, E-J., The controlled release of blue dextran from alginate beads. Int. J. Pharm., 79 (1992) 11-19.
5. Koji, D., Yutaka, W., Chiaki, Y., Mamabu, Y., Seiji, O., Masayuki, O. and Takashi, M., Pharmacological studies of sodium alginate. I. Protective effect of sodium alginate on mucous membranes of upper-gastrointestinal tract., Yakugaku Zasshi, 101 (1981) 452-457.
6. Lee, B-J. and Lee, J-R., Enhancement of solubility and dissolution rate of poorly water-soluble naproxen by complexation with 2-hydroxypropyl-β-cyclodextrin. Arch. Pharm. Res., 18 (1995) 22-26.
7. Lee, B.-J. and Min, G.-H., Preparation and release characteristics of polymer-reinforced and coated alginate beads. Arch. Pharm. Res., 18 (1995) 183-188.
8. Lee, B.-J., Parrott, K.A., Ayres, J.W. and Sack, R.L., Design and evaluation of an oral controlled release delivery system for melatonin in human subjects. Int. J. Pharm., 124 (1995) 119-127.
9. Lee, B.-J., Parrott, K. A., Ayres, J. W and Sack, R.L., Preliminary evaluation of transdermal delivery of melatonin in human subjects. Res. Comm. Mol. Pathol. Pharmacol., 85 (1994) 337-344.
10. Lehmann, K.O.R., Chemistry and application properties of polymethacrylate coating system, In Mc-Giminity, J.W. (Ed.), Aqueous polymeric coatings for pharmaceutical dosage forms; Marcel Dekker, New York (1989) 153-246.
11. Lin, S. and Ayres, J. W., Calcium alginate beads as core carriers of 5-aminosalicylic acid. Pharm. Res., (1992) 1128-1131.
12. Murata, Y., Maeda, T., Miyamoto, E. and Kawashima, S., Preparation of chitosan-reinforced alginate gel beads-effects of chitosan on gel matrix erosion. Int. J. Pharm., 96 (1993) 130-145.
13. Ostberg, T., Vesterhus, L. and Graffner, C., Calcium alginate matrices for oral multiple unit administration: II. Effect of process and formulation factors on matrix properties. Int. J. Pharm., 97 (1993) 183-193.
14. Ostberg, T., Lund, E.M. and Graffner, C., Calcium alginate matrices for oral multiple unit administration: IV. Release characteristics in different media. Int. J. Pharm., 112 (1994) 241-248.
15. Tomida, H., Nakamura, C., Yoshitomi, H. and Kiryu, S., Preparation of theophylline-loaded calcium alginate gel capsules and evaluation of their drug release characteristics. Chem. Pharm. Bull., 41 (1993) 1261-2165.
16. Sugawara, S., Imai, T. and Otagiri, M., The controlled release of prednisolone using alginate gel. Pharm. Res., 11 (1994) 272-277.
17. Yotsuyanagi, T., Ohkubo, T., Ohhashi, T. and Ikeda, K., Calcium-induced gelation of alginic acid and pH-sensitive reswelling of dried gels. Chem. Pharm. Bull., 35 (1987) 1555-1563.