Multiplex PCR reaction for the detection and identification of immunoglobulin kappa deleting element rearrangements in B-lineage leukaemias

British Journal of Haematology

Volumn 106, Issue 2, 1999, Pages 486-490

  Stolz, Frank ^a   Panzer, Simon ^b   Panzer Grümayer, E Renate ^a  

^a CHILDREN'S CANCER RESEARCH INSTITUTE   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

B lineage leukaemias; Ig kappa genes; Kde rearrangements; MRD; Multiplex PCR

Indexed keywords

IMMUNOGLOBULIN KAPPA CHAIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; B CELL LEUKEMIA; CHRONIC LYMPHATIC LEUKEMIA; GENE AMPLIFICATION; GENE REARRANGEMENT; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ADULT; CHILD; GENE DELETION; GENE REARRANGEMENT, B-LYMPHOCYTE; HUMANS; IMMUNOGLOBULIN KAPPA-CHAINS; LEUKEMIA, LYMPHOCYTIC, CHRONIC; LEUKEMIA, PRE-B-CELL; NEOPLASM, RESIDUAL; POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY;

EID: 0032857792     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1999.01557.x     Document Type: Article

References (17)

1. Beishuizen, A., de Bruijn, M.A.C., Pongers-Willemse, M.J., Verheoven, M.A.J., van Wering, E.R., Hählen, K., Breit, T.M., de Bruin-Versteeg, S., Hooijknas, H. & van Dongen, J.J.M. (1997) Heterogeneity in junctional regions of immunoglobulin kappa deleting element rearrangements in B cell leukemias: a new molecular target of minimal residual disease. Leukemia, 11, 2200-2207.
2. Beishuizen, A., Verhoeven, M.A.J., Mol, E.J. & van Dongen, J.J.M. (1994a) Detection of immunoglobulin kappa light chain gene rearrangement pattern by Southern blot analysis. Leukemia, 8, 2228-2236.
3. Beishuizen, A., Verhoeven, M-A.J., Van Wering, E.R., Hählen, K., Hooijkaas, H. & Van Dongen, J.J.M. (1994b) Analysis of immunoglobulin and T-cell receptor genes in 40 childhood acute lymphoblastic leukemias at diagnosis and subsequent relapse: implications for the detection or minimal residual disease by polymerase chain reaction analysis. Blood, 83, 2238-2247.
4. Brisco, M.J., Condon, J., Hughes, E., Neoh, S.H., Sykes, P.J., Seshadri, R., Toogood, I., Waters, K., Tauro, G. & Ekert, H. (1994) Outcome prediction in childhood acute lymphoblastic leukaemia by molecular quantification of residual disease at the end of induction. Lancet, 343, 196-200.
5. Cave, H., van de Werf ten Bosch, J., Suciu, S., Guidal, C., Waterkeyn, C.H., Otten, J., Bakkus, M., Thelemans, K., Grandchamp, B. & Vilmer, E. (1998) Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. European Organization for Research and Treatment of Cancer-Childhood Leukemia Cooperative Group. New England Journal of Medicine, 339, 591-598.
6. Graninger, W.B., Goldman, P.L., Morton, C.C., O'Brien, S.J. & Korsmeyer, S.J. (1988) The k-deleting element: germline and rearranged, duplicated and dispersed forms. Journal of Experimental Medicine, 167, 488-501.
7. Hettinger, K., Fischer, S., Panzer, S. & Panzer-Grümayer, E.R. (1998) Multiplex PCR for TCR delta rearrangements: a rapid and specific approach for the detection and identification of immature rearrangements in ALL. British Journal of Haematology, 102, 1050-1054.
8. Hieter, P.A., Korsmeyer, S.J., Waldmann, T.A. & Leder, P. (1981) Human immunoglobulin k light-chain genes are deleted or rearranged in λ-producing B-cells. Nature, 290, 368-372.
9. Klobeck, H.G. & Zachau, H.G. (1986) The human Ck gene segment and the kappa deleting element are closely linked. Nucleic Acids Research, 14, 4591-4603.
10. Mullis, K.B. & Faloona, F.A. (1987) Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. Methods in Enzymology, 155, 335-350.
11. Pongers-Willemse, M.J., Seriu, T., Stolz, F., Corral, C., Gameiro, P., Pisa, P., Gonzales, M., Bartram, C.R., Panzer-Grümayer, E.R., Biondi, A., San Miguel, J.F. & van Dongen, J.J.M. (1999) Primers and protocols for standardized MRD detection in ALL using immunoglobulin and T cell receptor gene rearrangements and TAL 1 deletions as PCR targets. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia. Leukemia, 13, 110-118.
12. Schneider, M., Panzer, S., Stolz, F., Fischer, S., Gadner, H. & Panzer-Grümayer, E.R. (1997) Crosslineage TCR delta rearrangements occur shortly after the DJ joinings of the IgH in childhood precursor B ALL and display age-specific characteristics. British Journal of Haematology, 99, 115-121.
13. Siminovitch, K.A., Bakhshi, A., Goldman, P. & Korsmeyer, S.J. (1985) A uniform deleting element mediates the loss of k genes in human B-cells. Nature, 16, 260-262.
14. Siminovitch, K.A., Moore, M.W., Durdik, J. & Selsing, E. (1987) The human kappa deleting element and the mouse recombining segment share DNA sequence homology. Nucleic Acids Research, 15, 2699-2705.
15. Steward, G.C., Goulden, N.J., Katz, F., Baines, D., Martin, P.G., Langlands, K., Potter, M.N., Chessells, J.M. & Oakhill, A. (1994) A polymerase chain reaction study of the stability of Ig heavy-chain and T cell receptor delta gene rearrangements between presentation and relapse of childhood B-lineage acute lymphoblastic leukemia. Blood, 83, 1355-1362.
16. Steenbergen, E.J., Verhagen, O.J.H.M., Van Leeuwen, E.F., Van den Berg, H., Von dem Borne, A.E.G.Kr. & Van der Schoot, C.E. (1995) Frequent ongoing TCR delta rearrangements in childhood precursor acute lymphoblastic leukemia: implications for monitoring minimal residual disease. Blood, 86, 692-702.
17. van Dongen, J.J.M., Seriu, T., Panzer-Grümayer, E.R., Biondi, A., Pongers-Willemse, M.J., Corral, L., Stolz, F., Schrappe, M., Masera, G., Kamps, W.A., Gadner, H., van Wering, E.R., Ludwig, W.D., Basso, G., de Bruijn, M.A., Cazzaniga, G., Hettinger, K., van der Does-van den Berg, A., Hop, W.C., Rhiem, H. & Bartram, C.R. (1998) Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood. Lancet, 352, 1731-1738.