Co-ordinate loss of protein kinase C and multidrug resistance gene expression in revertant MCF-7/Adr breast carcinoma cells

British Journal of Cancer

Volumn 75, Issue 9, 1997, Pages 1330-1335

  Budworth, J ^a   Gant, T W ^a   Gescher, A ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Doxorubicin; Mammary carcinoma; Multidrug resistance; Protein kinase C

Indexed keywords

DOXORUBICIN; GLYCOPROTEIN P; MESSENGER RNA; PROTEIN KINASE C;

ARTICLE; CARCINOMA CELL; CELLULAR DISTRIBUTION; DRUG SENSITIVITY; GENE EXPRESSION; MULTIDRUG RESISTANCE; PRIORITY JOURNAL;

EID: 0030990597     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.225     Document Type: Article

References (41)

1. Aftab DT, Yang JM and Hait WN (1994) Functional rule of phosphorylation of the multidrug transporter (P-glycoprotein) by protein kinase C in multidrug-resistant MCF-7 cells. Oncol Res 6: 59-70
2. Ahmad S and Glazer RI (1993) Expression of the antisense cDNA for protein kinase C-α attenuates resistance in doxorubicin-resistant MCF-7 breast carcinoma cells. Mol Pharmacol 43: 858-862
3. Baier G, Baier-Bitterlich G, Meller N, Coggeshall KM, Giampa L, Telford D, Isakov N and Altman A (1994) Expression and biochemical characterization of human protein kinase C-θ. Eur J Biochem 225: 195-203
4. Bates SE, Currier SJ, Alvarez M and Fojo AT (1992) Modulation of P-glycoprotein phosphorylation and drug transport by sodium butyrate. Biochemistry 31: 6366-6372
5. Bates SE, Lee JS, Dickstein B, Spolyar M and Fojo AT (1993) Differential modulation of P-glycoprotein transport by protein kinase inhibition. Biochemistry 32: 9156-9164
6. Beck J, Handgretinger R, Klingebiel T, Dopfer R, Schaich M, Ehninger G, Niethammer D and Gekeler V (1996) Expression of PKC isozyme and MDR-associated genes in primary and relapsed state AML. Leukemia 10: 426-433
7. Blobe GC, Sachs CW, Khan WA, Fabbro D, Stabel S, Wetsel WC, Obeid LM, Fine RL and Hannun YA (1993) Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. J Biol Chem 268: 658-664
8. Budworth J, Davies R, Malkhandi J, Gant TW, Ferry DR and Gescher A (1996) Comparison of staurosporine and four analogues: their effects on growth, rhodamine 123 retention and binding to P-glycoprotein in multidrug-resistant MCF-7/Adr cells. Br J Cancer 73: 1063-1068
9. Chambers TC, McAvoy EM, Jacobs JW and Eilon G (1990) Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells. J Biol Chem 265: 7679-7686
10. Chambers TC, Pohl J, Raynor RL and Kuo JF (1993) Identification of specific sites in human P-glycoprotein phosphorylated by protein kinase C. J Biol Chem 268: 4592-4595
11. Chambers TC, Pohl J, Glass DB and Kuo JF (1994) Phosphorylation by protein kinase C and cyclic AMP-dependent kinase of synthetic peptides derived from the linker region of human P-glycoprotein. Biochem J 299: 309-315
12. Chambers TC, Germann UA, Gottesman MM, Pastan I, Kuo JF and Ambudkar SV (1995) Bacterial expression of the linker region of human MDR1 p-glycoprotein and mutational analysis of phosphorylation sites. Biochemistry 34: 14156-14162
13. Chaudhary PM and Roninson IB (1992) Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists. Oncol Res 4: 281-290
14. Dahllof B, Martinsson T and Levan G (1984). Resistance to actinomycin D and to vincristine induced in a SEWA mouse tumor cell line with concomitant appearance of double minutes and a low molecular weight protein. Exp Cell Res 152: 415-426
15. Davies R, Budworth J, Riley J, Snowden R, Gescher A and Gant TW (1996) Regulation of P-glycoprotein 1 and 2 gene expression and protein activity in two MCF-7/Dox cell line subclones. Br J Cancer 73: 307-315
16. Dong Z, Ward N, Fan D, Gupta KP and O'Brian CA (1991) In vitro model for intrinsic drug resistance: effects of PKC activators on the chemosensitivity of cultured human colon cancer cells. Mol Pharmacol 39: 563-569
17. Fairchild CR, Kao-Shan C-S, Wang-Peng J, Rosen N, Israel MA, Malera PW, Cowan KH and Goldsmith MF (1987) Isolation of amplified and overexpressed DNA sequences from adriamycin-resistant human breast cancer cells. Cancer Res 47: 5141-5148
18. Fine RL, Patel J and Chabner BA (1988) Phorbol esters induce multidrug resistance in human breast cancer cells. Proc Natl Acad Sci USA 85: 582-586
19. Finkenzeller G, Marme D and Hug H (1990) Sequence of human protein kinase C alpha. Nucleic Acids Res 18: 2183
20. Fojo A, Lebo R, Shimizu N, Chin JF, Roninson IB, Merlino GT, Gottesman MM and Pastan I (1986) Localization of multidrug resistance-associated DNA-sequences to human chromosome-7. Somat Cell Mol Genet 12: 415-420
21. Gekeler V, Boer R, Überall F, Ise W, Schubert C, Utz I, Hofmann H, Sanders KH, SchÄchtele C, Klemm K and Grunicke H (1996) Effects of the selective bisindolylmaleimide protein kinase C inhibitor GF 109203X on P-glycoprotein-mediated multidrug resistance. Br J Cancer 74: 897-905
22. Germann UA, Chambers TC, Ambudkar SV, Licht T, Cardarelli CO, Pastan I and Gottesman MM (1996) Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells. J Biol Chem 271: 1708-1716
23. Goodfellow HR, Sardini A, Ruetz S, Callaghan R, Gros P, Menaughton PA and Higgins CF (1996) Protein kinase C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein. J Biol Chem 271: 13668-13674
24. Gottesman MM and Pastan I (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62: 385-427
25. Gupta KP, Ward NE, Gravitt KR, Bergman PJ and O'Brian CA (1996) Partial reversal of multidrug resistance in human breast cancer cells by an N-myristoylated protein kinase C-α pseudosubstrate peptide. J Biol Chem 271: 2102-2111
26. r 170,000 to 180,000 glycoprotein specific to multidrug-resistant tumor cells: effects of verapamil, trifluoperazine and phorbol esters. Cancer Res 47: 2860-2865
27. Madden MJ, Morrow CS, Nakagawa M, Goldsmith ME, Fairchild CR and Cowan KH (1993) Identification of 5′ and 3′ sequences involved in the regulation of transcription of the human mdr1 gene in vivo. J Biol Chem 268: 8290-8297
28. Meyers MB, Spengler BA, Chang T, Melera PW and Biedler JL (1985) Gene amplification-associated cytogenetic aberrations and protein changes in vincristine-resistant Chinese hamster, mouse and human cells. J Cell Biol 100: 588-597
29. Morrow CS, Chiu J and Cowan KH (1992) Posttranscriptional control of glutathione S-transferase π gene expression in human breast cancer cells. J Biol Chem 267: 10544-10550
30. O'Brian CA, Fan D, Ward NE, Seid C and Fidler IJ (1989) Level of protein kinase C activity correlates directly with resistance to adriamycin in murine fibrosarcoma cells. FEBS Lett 246: 78-82
31. Posada J, Vichi P and Tritton TR (1989) Protein kinase C in adriamycin action and resistance in mouse sarcoma 180 cells. Cancer Res 49: 6634-6639
32. Riordan JR, Deuchars K, Kartner N, Alon N, Trent J and Ling V (1985) Amplification of P-glycoprotein genes in multidrug resistant mammalian cell lines. Nature 316: 817-819
33. Sachs CW, Safa AR, Harrison SD and Fine RL (1995) Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C. J Biol Chem 270: 26639-26648
34. Sato W, Yusa K, Naito M and Tsuruo T (1990) Staurosporine, a potent inhibitor of C-kinase, enhances drug accumulation in multidrug-resistant cells. Biochem Biophys Res Commun 173: 1252-12570
35. Scala S, Dickstein B, Regis J, Szallasi Z, Blumberg PM and Bates SE (1995) Bryostatin 1 affects P-glycoprotein phosphorylation but not function in multidrug-resistant human breast cancer cells. Clin Cancer Res 1: 1581-1587
36. Smith CD and Zilfou JT (1995) Circumvention of P-glycoprotein-mediated multiple drug resistance by phosphorylation modulators is independent of protein kinases. J Biol Chem 270: 28145-28152
37. Stanwell C, Gescher A, Bradshaw TD and Pettit GR (1994) The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin 1 in human A549 lung and MCF-7 breast carcinoma cells. Int J Cancer 56: 585-592
38. Ueda K, Cardarelli C, Gottesman MM and Pastan I (1987) Expression of a full length cDNA for the human 'MDR1' gene confers resistance to colchicine, doxorubicin and vinblastine. Proc Natl Acad Sci USA 84: 3004-3008
39. Utz I, Hofer S, Regenass U, Hilbe W, Thaler J, Grunicke H and Hofmann J (1994) The protein kinase C inhibitor CGP 41251, a staurosporine derivative with antitumor activity, reverses multidrug resistance. Int J Cancer 57: 104-110
40. Yu G, Ahmad S, Aquino A, Fairchild CR, Trepel JB, Ohno S, Suzuki K, Tsuruo T, Cowan KH and Glazer RI (1991) Transfection with protein kinase C-α confers increased multidrug resistance to MCF-7 cells expressing P-glycoprotein. Cancer Commun 3: 181-189
41. Zhang F, Riley J and Gant TW (1996) Use of internally controlled reverse transcripase-polymerase chain reaction for absolute quantitation of individual multidrug resistant gene transcripts in tissues samples. Electrophoresis 17: 255-260