Expression, regulation and clinical significance of bone morphogenetic protein 6 in esophageal squamous-cell carcinoma

International Journal of Cancer

Volumn 83, Issue 1, 1999, Pages 38-44

  Raida, Martin ^a   Sarbia, Mario ^b   Clement, Joachim H ^a   Adam, Susanne ^a   Gabbert, Helmut E ^b   Höffken, Klaus ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 6; EPIDERMAL GROWTH FACTOR RECEPTOR;

ARTICLE; CANCER STAGING; CANCER SURVIVAL; CYTOKINE PRODUCTION; ESOPHAGUS CARCINOMA; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; KERATINIZATION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SQUAMOUS CELL CARCINOMA; TUMOR DIFFERENTIATION;

ADULT; AGED; AGED, 80 AND OVER; BONE MORPHOGENETIC PROTEINS; CARCINOMA, SQUAMOUS CELL; CULTURE MEDIA, SERUM-FREE; ESOPHAGEAL NEOPLASMS; ESOPHAGUS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOPHARYNGEAL NEOPLASMS; IMMUNOHISTOCHEMISTRY; KERATINOCYTES; MALE; MIDDLE AGED; PROGNOSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURVIVAL RATE; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0032856555     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990924)83:1<38::AID-IJC8>3.0.CO;2-B     Document Type: Article

References (31)

1. AARONSON, S. A., Growth factors and cancer. Science, 254, 1146-1153 (1991).
2. BENTLEY, H., HAMDY, F.C., HART, K.A., SEID, J.M., WILLIAMS, J.L., JOHNSTONE, D. and RUSSELL, R.G.G., Expression of bone morphogenetic proteins in human prostatic adenocarcinoma and benign prostatic hyperplasia. Brit. J. Cancer, 66, 1159-1163 (1992).
3. BLESSING, M., SCHIRMACHER, P. and KAISER, S., Overexpression of bone morphogenetic protein-6 (BMP-6) in the epidermis of transgenic mice: inhibition or stimulation of proliferation depending on the pattern of transgene expression and formation of psoriatic lesions. J. Cell Biol., 135, 227-239 (1996).
4. CELESTE, A.J., IANNAZZI, J.A., TAYLOR, R.C., HEWICK, R.M., ROSEN, V., WANG, E.A. and WOZNEY, J.M., Identification of transforming growth factor β family members present in bone-inductive protein purified from bovine bone. Proc. nat. Acad. Sci. (Wash.), 87, 9843-9847 (1990).
5. CLEMENT, J.H., SÄNGER, J. and HÖFFKEN, K., Expression of bone morphogenetic protein 6 (BMP-6) in normal mammary tissue and breast cancer cell lines and its regulation by epidermal growth factor EGF. Int. J Cancer, 80, 250-256 (1999).
6. DROZDOFF, V., WALL, N.A. and PLEDGER, W.J., Expression and growth inhibitory effect of decapentaplegic Vg-related protein 6: evidence for a regulatory role in keratinocyte differentiation. Proc. nat. Acad. Sci. (Wash.), 91, 5528-5532 (1994).
7. FRY, D.W., KRAKER, A.J., MCMICHAEL, A., AMBROSO, L.A., NELSON, J.M., LEOPOLD, W.R., CONNORS, R.W. and BRIDGES, A.J., A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science, 265, 1093-1095 (1994).
8. GLICK, A.B., KULKARNI, A.B., TENNENBAUM, T., HENNINGS, H., FLANDERS, K.C., O'REILLY, M., SPORN, M.B., KARLSSON, S. and YUSPA, S.H., Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion. Proc. nat. Acad. Sci. (Wash.), 90, 6076-6080 (1993).
9. HAMDY, F.C., AUTZEN, P., ROBINSON, M.C., HORNE, C.H.W., NEAL, D.E. and ROBSON, C.N., Immunolocalization and messenger RNA expression of bone morphogenetic protein-6 in human benign and malignant prostatic tissue. Cancer Res., 57, 4427-4431 (1997).
10. HELDIN, C.H., Dimerization of cell surface receptors in signal transduction. Cell. 80, 213-223 (1995).
11. HELDIN, C.H., MIYAZONO, K. and TEN DUKE, P., TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature(Lond.), 390, 465-471 (1997).
12. HOGAN, B.L., Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev., 10, 1580-1594 (1996).
13. HOWL-EVANS, W., MCCONNELL, R.B. and CLARKE, C.A., Carcinoma of the esophagus with keratosis palmaris et plantaris (tylosis). Q. J. Med., 27, 413-418 (1958).
14. KRAJEWSKA, M., KRAJEWSKI, S., EPSTEIN, J.I., SHABAIK, A., SAUVAGEOT, J., SONG, K., KITADA, S. and REED, J.C., Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate carcinomas. Amer. J. Pathol. 148, 1567-1576 (1996).
15. MARQUARDT, H., HUNKAPILLER, M.W., HOOD, L.E. and TODARO, G.J., Rat transforming growth factor type 1: structure and relations to epidermal growth factor. Science, 223, 1079-1082 (1984).
16. MONTESANO, R., HOLLSTEIN, M. and HAINAUT, P., Genetic alterations in esophageal cancer and their relevance to etiology and pathogenesis. Int. J. Cancer, 69, 225-235 (1996).
17. MUKAIDA, H., TOI, M., HIRAI, T., YAMASHITA, Y. and TOGE, T., Clinical significance of the expression of epidermal growth factor and its receptor in esophageal cancer. Cancer, 68, 142-148 (1991).
18. PARKER, S.L., TONG, T., BOLDEN, S. and WINGO, P.A., Cancer statistics (abstract). CA, 46, 5 (1996).
19. RANGAN, S.R., A new human cell line (FaDu) from a hypopharyngeal carcinoma. Cancer, 29, 117-121 (1972).
20. RISK, J.M., FIELD, E.A. and FIELD, J.K., Tylosis oesophageal cancer mapped. Nature Genet., 8, 319-321 (1994).
21. SARBIA, M., BITTINGER, F., FORSCHEN, R., DUTTKOWSKI, P., WILLERS, R. and GABBERT, H.E., Prognostic value of histopathological parameters in squamous cell carcinoma of the esophagus. Cancer, 76, 922-927 (1995).
22. SCHLUESENER, H.J. and MEYERMANN, R., Immunolocalization of BMP-6, a novel TGF-β-related cytokine, in normal and atherosclerotic smooth muscle cells. Atherosclerosis, 113, 153-156 (1995).
23. SHING, Y., CHRISTOFORI, G., HANAHAN, D., ONO, Y., SASADA, R., IGARASHI, K. and FOLKMAN, J., Betacellulin: a mitogen from pancreatic beta cell tumors. Science, 259, 1604-1607 (1993).
24. SHOYAB, M., PLOWMAN, G.D., MCDONALD, V.L., BRADLEY, J.G. and TODARO, G.J., Structure and function of human amphiregulin: a member of the epidermal growth factor family. Science, 243, 1074-1076 (1989).
25. SOBIN, L.H. and WITTEKIND, C. (eds.), TNM classification of malignant tumours (5th ed.), Wiley-Liss, New York (1997).
26. TAKAHASHI, H., SHIKATA, N. and SENZAKI, H., Immunohistochemical staining patterns of keratins in normal oesophageal epithelium and carcinoma of the esophagus. Histopathology, 26, 45-50 (1995).
27. URIST, M.R., Bone: formation by auto-induction. Science, 150, 893-899 (1965).
28. WALL, N.A., BLESSING, M., WRIGHT, C.V.E. and HOGAN, B. L., Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). J. Cell Biol., 120, 493-502 (1993).
29. WORLD HEALTH ORGANIZATION, Histological typing of oesophageal and gastric tumours (2nd ed.), Springer, Berlin (1990).
30. WOZNEY, J.M., ROSEN, V., CELESTE, A.J., MITSOCK, L.M., WHITTERS, M.J., KRIZ, R.W., HEWICK, R.M. and WANG, E.A., Novel regulators of bone formation: molecular clones and activities. Science, 242, 1528-1534 (1988).
31. YANO, H., SHIOZAKI, H. and KOBAYASHI, K., Immunohistochemical detection of the epidermal growth factor receptor in human esophageal squamous cell carcinoma. Cancer, 67, 91-98 (1991).