Three-dimensional simulation of IgG delivery to tumors

Chemical Engineering Science

Volumn 53, Issue 20, 1998, Pages 3579-3600

  Wang, Chi Hwa ^a   Li, Jian ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

IgG; Polymeric delivery; Simulation; Systemic administration; Tumor

Indexed keywords

MONOCLONAL ANTIBODIES; ONCOGENIC VIRUSES; POLYMERS;

POLYMER-BASED CONTROLLED RELEASE;

CONTROLLED DRUG DELIVERY;

MEDICAL APPLICATION;

EID: 0032538650     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2509(98)00173-0     Document Type: Article

References (35)

1. Baxter, L. T. and Jain, R. K. (1989) Transport of fluid and macromolecules in tumors. I Role of interstitial pressure and convection. Microvasc. Res. 37, 77-104.
2. Baxter, L. T. and Jain, R. K. (1990) Transport of fluid and macromolecules in tumors. II Role of heterogeneous perfusion and lymphatics. Microvasc. Res. 40, 246-263.
3. Baxter, L. T. and Jain, R. K. (1991) Transport of fluid and macromolecules in tumors. III Role of binding and metabolism. Microvasc. Res. 41, 5-23.
4. Blakeslee, S. (1989) Impenetrable tumors found to block even the newest cancer agents. The New York Times, June 27, 1989.
5. Boucher, Y., Baxter, L. T. and Jain, R. K. (1990) Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: Implication for therapy, Cancer Res. 50, 4478-4484.
6. Brem, H., Piantadosi, S., Burger, P. C., Walker, M., Selker, R., Vick, N. A., Black, K., Sisti, M., Brem, S., Mohor, G., Muller, P., Morawetz, R. and Schold, S. C. (1995) Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. The Lancet 345, 1008-1012.
7. Curry, F. E. (1984) Mechanics and thermodynamics of transcapillary exchange. In Handbook of Physiology, Section 2: The Cardiovascular System, eds E. M. Renkin and C. C. Michel, pp. 309-374. Amer. Physiol. Soc., Bethesda, MD, U.S.A.
8. Fluid Dynamics International, Inc. (1995) FIDAP User Manual.
9. 2 and Fab in tumors. Cancer Res. 49, 5656-5663.
10. Fujimori, K., Fisher, D. R. and Weinstein, J. N. (1991) Integrated microscopic-macroscopic pharmacology of Monoclonal antibody radioconjugates: The radiation dose distribution. Cancer Res. 51, 4821-4827.
11. ® WAFER.
12. ® WAFER. Design News, June 10, 1996.
13. Huang, L. (1997) Controlled Release of Human Immunoglobulin G (IgG) from ethylene-vinyl acetate copolymer (EVAc). NURP Report, National University of Singapore.
14. Jain, R. K. (1987) Transport of molecules in the tumor interstitium: A review. Cancer Res. 47, 3039-3051.
15. Jain, R. K. and Baxter, L. T. (1988) Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure. Cancer Res. 48, 7022-7032.
16. Jain, R. K. (1996) Delivery of molecular medicine to solid tumors. Science 271, 1079-1080.
17. Langer, R., Brem, H. and Tapper, D. (1981) Biocompatibility of polymeric delivery systems for macromolecules. J. Biomed. Mater. Res. 15, 267-277.
18. Leong, K. W., Brott, B. C. and Langer, R. (1985) Bioerodible polyanhydrides as drug-carrier matrices. I. Characteristics, degradation, and release characteristics. J. Biomed. Mater. Res. 19, 941-955.
19. Leong, K. W., D'Amore, P., Marletta, M. and Langer, R. (1986) Bioerodible polyanhydrides as drug-carrier matrices. II. Biocompatibility and chemical reactivity. J. Biomed. Mater. Res. 20, 51-64.
20. Levin, V. A., Patlak, C. S. and Landahl H. D. (1980) Heuristic modeling of drug delivery to malignant tumors. J. Pharm. and Biopharm., 8, 257-296.
21. Li, J. (1998) A three-dimensional model of drug delivery to brain tumors, M. Eng thesis, Department of Chemical Engineering, National University of Singapore.
22. Li, J. and Wang, C.-H. (1997) Two-dimensional simulation of IgG delivery to tumors. Regional Symposium on Chemical Engineering 1997 (RSCE'97), Vol. 2, 585-591, Johor, Malaysia.
23. Lianhe Zhaobao (1996) Brain Tumor Patients Can Get Help from Experts, Aug. 16, 1996.
24. Netti, P. A., Baxter, L. T., Boucher, Y., Skalak, R. and Jain, R. K. (1995) Time-dependent behavior of interstitial fluid pressure in solid tumors: implication for drug delivery. Cancer Res. 55, 5451-5458.
25. Nugent, L. J. and Jain, R. K. (1984) Extravascular diffusion in normal and neoplastic tissues. Cancer Res. 44, 238-244.
26. Parker, R. J., Keenan, A. M., Dower, S. K., Steller, M. A., Holton, O. D., Sieber, S. M. and Weinstein, J. N. (1987) Targeting of murine radiolabeled monoclonal antibodies in the lymphatics. Cancer Res. 47, 2073-2076.
27. Peppas, N. A. (1983) A model of dissolution-controlled solute release from porous drug delivery polymeric systems. J. Biomed. Mater. Res. 17, 1079-1087.
28. Pirofsky, B. (1984) Intravenous immune globulin therapy in hypogammaglobulinemia: A review. Amer. J. Med. March 30, 1984, 53-60.
29. Saltzman, W. M. and Radomsky, M. L. (1991) Drugs released from polymers: diffusion and elimination in brain tissue. Chem. Engng Sci. 46, 2429-2444.
30. Sengothi K. (1998) Sustained release of human Immunoglobulin G from ethylene-vinyl acetate copolymer, Half-year Progress Report, Department of Chemical Engineering, National University of Singapore.
31. Steller, M. A., Parker, R. J., Covell, D. C., Holton, O. D. III, Keenan, A. M., Sieber, S. M. and Weinstein, J. N. (1986) Optimization of monoclonal antibody delivery via the lymphatics: The dose dependence. Cancer Res. 46, 1830-1834.
32. Tamargo, R. J., Epstein, J. I., Reinhard, C. S., Chasin, M. and Brem, H. (1989) Brain biocompatibility of a biodegradable, controlled-release polymer in rats. J. Biomed. Mater. Res. 23, 253-266.
33. Tamargo, R. J., Myseros, J. S., Epstein, J. I., Yang, M. B., Chasin, M. and Brem, H. (1993) Interstitial chemotherapy of the 9L Gliosarcoma: Controlled release polymers for drug delivery in the brain, Cancer Res. 53, 329-333.
34. Virella, G. (1993) Immunoglobulin structure. In Introduction to Medical Immunology, 3rd ed, pp. 75-91. Marcel Dekker, New York.
35. Wang, C. H., Li, J., Teo, C. S. and Lee, T. (1997) Computer Simulation of BCNU delivery to brain tumors. Proceedings of the 9th International Conference on Biomedical Engineering, pp. 263-265, Singapore.