The N-terminal half of Cdc25 is essential for processing glucose signaling in Saccharomyces cerevisiae

Biochemistry

Volumn 38, Issue 40, 1999, Pages 13252-13262

  Gross, Atan ^a   Winograd, Sabina ^a   Marbach, Irit ^a   Levitzki, Alexander ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; RAS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; ELECTROPHORETIC MOBILITY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE DELETION; GENE OVEREXPRESSION; GLUCOSE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

ANIMALS; CATALYTIC DOMAIN; CELL CYCLE PROTEINS; ENZYME ACTIVATION; FUNGAL PROTEINS; GLUCOSE; GUANINE NUCLEOTIDES; GUANYLATE CYCLASE; HUMANS; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RAS-GRF1; SACCHAROMYCES CEREVISIAE; SEQUENCE DELETION; SIGNAL TRANSDUCTION;

MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 0032856160     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9909849     Document Type: Article

References (49)

1. Broek, D., Toda, T., Michaeli, T., Levin, L., Birchmeier, C., Zoller, M., Powers, S., and Wigler, M. (1987) The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway. Cell 48, 789-799.
2. Daniel, J., Becker, J. Enari, B., and Levitzki, A. (1987) The activation of adenylate cyclase by guanyl nucleotides in Saccharomyces cerevisiae is controlled by the CDC25 start gene product. Mol. Cell. Biol. 7, 3857-3861.
3. Jones, S., Vignais, M.-L., and Broach, J. (1991) The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras. Mol. Cell. Biol. 11, 2641-2646.
4. Robinson, L. C., Gibbs, J. B., Marshall, M. S., Sigal, I. S., and Tatchell, K. (1987) CDC25: a component of the RAS-adenylate cyclase pathway in Saccharomyces cerevisiae, Science 235, 1218-1221.
5. Munder, T., and Kuntzel, H. (1989) Glucose-induced cAMP signaling in Saccharomvces cerevisiae is mediated by the CDC25 protein. FEBS Lett. 242, 341-345.
6. Buchsbaum, R., Telliez, J. B., Goonesekera, S., and Feig, L. A. (1996) The N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor ras-GRF act cooperatively to facilitate activation by calcium. Mol. Cell. Biol. 16, 4888-4896.
7. Martegani, E., Vanoni, M., Zippel, R., Coccetti, P., Brambilla, R., Ferrari, C., Sturani, E., and Alberghina, L. (1992) Cloning by functional complementation of the mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator. EMBO J. 11, 2151-2157.
8. Zippel, r., Orecchia, S., Sturani, E., and Martegani, E. (1996) The brain specific Ras Exchange factor CDC25Mm: modulation of its activity through Gi-protein mediated signals. Oncogene 12, 2697-2703.
9. Mattingly, R. R., and Macara, I. G. (1996) Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein βγ subunits. Nature 382, 268-272.
10. Aronheim, A., Engelberg, D., Li, N., Al-Alawi, N., Schlessinger, J., and Karin, M. (1994) Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. Cell 78, 949-961.
11. McCollam, L., Bonfini, L., Karlovich, C. A., Conway, B. R., Kozma, L. M., Banerjee, U., and Czech, M. P. (1995) Functional roles for the pleckstrin and Dbl homology regions in the Ras exchange factor Son-of-sevenless. J. Biol. Chem. 270, 15954-15957.
12. Wang, W., Fisher, E. M. C., Jia, Q., Dunn, J. M., Porfiri, E., Downward, J., and Egan, S. E. (1995) The Grb2 binding domain of mSos1 is not required for downstream signal transduction. Nat. Genet. 10, 294-300.
13. Corbalan-Garcia, S., Margarit, S. M., Galron, D., Yang, S., and Bar-Sagi, D. (1998) Regulation of Sos activity by intramolecular interactions. Mol. Cell Biol. 18, 880-886.
14. Qian, X., Vass, W. C., Papageorge, A. G., Anborgh, P. H., Lowy, D. R. (1998), N Terminus of Sos1 Ras Exchange Factor: Critical roles for the Dbl and Plextrin Homology Domains. Mol. Cell Biol. 18, 771-778.
15. Gross, E., Goldberg, D., and Levitzki, A. (1992) Phosphorylation of the S. cerevisiae Cdc25 in response to glucose results in its dissociation from Ras. Nature 360, 762-765.
16. Cherniack, A. D., Klarlund, J. K., and Czech, M. P. (1994) Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase. J. Biol. Chem. 269, 4717-4720.
17. Cherniack, A. D., Klarlund, J. K., Conway, B. R., and Czech, M. P. (1995) Disassembly of Son-of-sevenless proteins from Grb2 during p21ras desensitization by insulin. J. Biol. Chem. 270, 1485-1488.
18. Boguski, M. S., and McCormick, F. (1993) Proteins regulating Ras and its relatives. Nature 366, 643-654.
19. Quilliam, L. A., Khosravi-Far, R., Huff, S. Y., and Der, C. J. (1995) Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins. BioEssays 17, 395-404.
20. Sambrook, J., Frisch, E. F., and Maniatis, T. (1989) Molecular cloning: a laboratory manual, 2nd ed., Cold Spring Harbor Laboratory, Plainview, NY.
21. Ito, H., Fuknda, Y., Murata, K., and Kimura, A. (1983) Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153, 163-168.
22. Sikorski, R. S., and Hieter, P. (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19-27.
23. Ballester, R., Michaeli, T., Fergunson, K., Xu, H., McCormick, F., and Wigler, M. (1989) Genetic analysis of mammalian GAP expressed in yeast. Cell 59, 681-686.
24. Clark, S. G., Mcgrath, J. P., and Levinson, A. D. (1985) Expression of normal and activated human Ha-ras cDNAs in Saccharomyces cerevisiae. Mol. Cell. Biol. 5, 2746-2752.
25. Sanger, F., Nicklen, S., and Coulson, A. R. (1977) DNA sequencing with chain terminating inhibitors. Proc. Natl. Acad. Sci. U.S.A. 74, 5463-5469.
26. Devereux, J., Haeberli, P., and Smithies, O. (1984) A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12, 387-395.
27. Garreau, H., Camonis, J. H., Guitton, C., and Jacquet, M. (1990) The Saccharomyces cerevisiae CDC25 gene product is a 180 kDa polypeptide and is associated with a membrane fraction. FEBS Lett. 269, 53-59.
28. Lowry, O. H., Rosebrough, A. L., Farr, A. L., and Randall, R. J. (1951) Protein measurements with Folin phenol reagent. J. Biol. Chem. 193, 265-275.
29. Peterson, G. L. (1977) A Simplification of the protein assay method of Lowry et al., which is more generally applicable. Anal. Biochem. 83, 346-356.
30. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
31. Gross, E., Marbach, I., Engelberg, D., Segal, M., Simchen, G., and Levitzki, A. (1992) Anti-Cdc25 antibodies inhibit guanyl nucleotide-dependent cyclase of Saccharomyces cerevisiae and cross react with a 150-kilodalton mammalian protein. Mol. Cell. Biol. 12, 2653-2661.
32. Kaibuchi, K., Miyajima, A., Arai, K.-L., and Matsumoto, K. (1986) Possible involvement of Ras-encoded proteins in glucose-induced inositolphospholipid turnover in Saccharomvces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 83, 8172-8176.
33. Casperson, G. F., Walker, N., Brasier, A. R., and Bourne, H. R. (1983) A guanine nucleotide-sensitive adenylate cyclase in the yeast Saccharomyces cerevisiae. J. Bio. Chem. 258, 7911-7914.
34. Engelberg, D., Simchen, G., and Levitzki, A. (1990) In vitro reconstitution of CDC25 regulated S. cerevisiae adenylyl cyclase and its kinetic properties. EMBO J. 9, 641-651.
35. Salomon, Y., London, C., and Rodbell, M. (1974) A highly sensitive adenylate cyclase assay. Anal. Biochem. 58, 541-548.
36. Tanaka, K., Matsumoto, K., and Toh-e, A. (1989) IRAI, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae. Mol. Cell. Biol. 9, 757-768.
37. Tanaka, K., Lin, B. K., Wood D. R., and Tamanoi, F. (1991) IRA2, an upstream negative regulator of RAS in yeast, is a RAS GTPase-activating protein. Proc. Natl. Acad. Sci. 88, 468-472.
38. Shou, C., Farnsworth, C. L., Neel, B. G., and Feig, L. A. (1992) Molecular cloning of cDNA encoding a guanine-nucleotide-releasing factor for Ras p21. Nature 358, 351-354.
39. Karlovich, C. A., Bonfini, L., McCollam, L., Rogge, R. D., Daga, A., P., C. M., and U., B. (1995) In vivo functional analysis of the Ras exchange factor son of sevenless. Science 268, 576-579.
40. Schomerus, C., Munder, T., and Kuntzel, H. (1990) Site-directed mutagenesis of the Saccharomyces cerevisiae CDC25 gene: effects on mitotic growth and cAMP signaling. Mol. Gen. Genet. 223, 426-432.
41. Thevelein, J. M. (1994) Signal transduction in Yeast. Yeast 10, 1753-1790.
42. Kaplon, T., and Jacquet, M. (1995) The cellular content of Cdc25p, the ras exchange factor in Saccharomyces cerevisiae, is regulated by destabilization through a cyclin destruction box. J. Biol. Chem. 270, 20742-20747.
43. Van Aelst, L., Boy-Marcotte, E., Camonis, J. H., Thevelein, J. M., and Jacquet, M. (1990) The C-terminal part of the CDC25 gene product plays a key role in signal transduction in the glucose-induced modulation of cAMP level in Saccharomyces cerevisiae. Eur. J. Biochem. 193, 675-680.
44. Freeman, N. L., Lila, T., Mintzer, K. A., Chen, Z., Pahk, A. J., Ren, R., Drubin, D. G., and Field, J. (1996) A conserved proline-rich region of the Saccharomyces cerevisiae cyclase-associated protein binds SH3 domains and modulates cytoskeletal localization. Mol. Cell. Biol. 16, 548-556.
45. Goldberg, D., Segal, M., and Levitzki, A. (1994) Cdc25 is not the signal receiver for glucose induced cAMP response in S. cerevisiae. FEBS Lett. 356, 249-254.
46. Buday, L., Warne, P. H., and Downward, J. (1995) Down-regulation of the Ras activation pathway by MAP kinase phosphorylation of Sos. Oncogene 11, 1327-1331.
47. Burgering, B. M. T., Pronk, G. J., van Weeren, P. C., and Bos, J. L. (1993) cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. EMBO J. 12, 4211-4220.
48. Langlois, W. J., Sasaoka, T., Saltiel, A. R., and Olefsky, J. M. (1995) Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation. J. Biol. Chem. 270, 25320-25323.
49. Waters, S. B., Yamauchi, K., and Pessin, J. E. (1995) Insulin-stimulated disassociation of the SOS-Grb2 complex. Mol. Cell. Biol. 15, 2791-2799.