Hepatic first-pass effect and controlled drug delivery following rectal administration

Advanced Drug Delivery Reviews

Volumn 28, Issue 2, 1997, Pages 229-237

  De Boer, A G ^a   Breimer, D D ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Absorption; Enhancement; Rectal; Simulation

Indexed keywords

ABSORPTION; COMPUTER SIMULATION; PHARMACOKINETICS;

HEPATIC FIRST PASS EFFECTS;

CONTROLLED DRUG DELIVERY;

CEFAZOLIN; DEETHYLLIDOCAINE; LIDOCAINE; THEOPHYLLINE DERIVATIVE;

COMPUTER SIMULATION; CONTROLLED DRUG RELEASE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DOSAGE FORM; DRUG ELIMINATION; FIRST PASS EFFECT; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER METABOLISM; PRIORITY JOURNAL; RECTAL DRUG ADMINISTRATION; REVIEW; STEADY STATE;

EID: 0031563892     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(97)00074-4     Document Type: Review

References (37)

1. A.G. de Boer, D.D. Breimer, GI-tract Absorption Enhancement: General Introduction and Simulation of Time-Concentration-Effect Profiles of Absorption Enhancers, in: A.G. de Boer (Ed.), Drug Absorption Enhancement: Concepts, Possibilities, Limitations and Trends, Vol. 3 in the series of Drug Targeting and Delivery, Harwood Academic Publishers GmbH, Amsterdam, The Netherlands, 1994, pp. 155-175.
2. A.G. de Boer, E.J. Hoogdalem, D.D. Breimer, Rate controlled rectal peptide absorption enhancement. In Penetration enhancement for polypeptides through epithelia in: Advanced Drug Delivery Reviews, 1992, 8(2/3), 237-253.
3. E.J. van Hoogdalem, A.G. de Boer, D.D. Breimer, Pharmacokinetics of rectal drug administration, part I: general considerations and clinical applications of centrally acting drugs, Clin. Pharmacokinet. 21(1) (1991) 11-26.
4. E.J. van Hoogdalem, A.G. de Boer, D.D. Breimer, Pharmacokinetics of rectal drug administration, part II: clinical applications of peripherally acting drugs and conclusions, Clin. Pharmacokinet. 21(2) (1991) 110-128.
5. S. Muranishi, Characteristics of drug absorption via the rectal route, Methods and Findings in Experimental Clinical Pharmacology 6 (1984) 763-772.
6. D.J.A. Crommelin, J. Modderkolk, C.J. de Blaey, The pH dependence of rectal absorption of theophylline from solutions of aminophylline in situ in rats. Int. J. Pharmaceut. 3 (1979) 299-309.
7. C.J. De Blaey, J. Polderman, Rationale in the design of rectal and vaginal delivery forms of drugs, in: Ariens Drug Design, Vol. 9. Academic Press, London, 1980
8. A.G. de Boer, L.G.J. de Leede, D.D. Breimer, Rectal and sublingual drug absorption, Brit. J. Anaesthesia 56 (1984) 69-82.
9. B.W. Müller, (Ed.), Suppositoriën, Wissenschaftliche Verlagsgesellschaft GmbH, Stuttgart, 1986
10. A.G. de Boer, F. Moolenaar, L.G.J. de Leede, D.D. Breimer, Rectal drug administration: clinical pharmacokinetic considerations, Clin. Pharmacokinet. 7 (1982) 285-311.
11. A.G. de Boer, D.D. Breimer, H. Mattie, J. Pronk, J.M. Gubbens-Stibbe, Rectal bioavailability of lidocaine in man: partial avoidance of first-pass metabolism, Clin. Pharmacol. Ther. 26 (1979) 701-709.
12. L.G.J. de Leede, A.G. de Boer, C.D. Feijen, D.D. Breimer, Site specific rectal drug administration in man with an osmotic system: influence on first-pass elimination of lidocaine, Pharm. Res. 1(3) (1984) 129-135.
13. OSMET™, ALZA Corporation, Palo Alto, California, USA.
14. K.K. Adjepon-Yamoah, L.F. Prescott, Lignocaine metabolism in man, Brit. J. Pharmacol. 47 (1973) 672P-673P.
15. L.G.J. de Leede, C.F. Hug, A.G. de Boer, D.D. Breimer, S. de Lange, Zero-order i.v. and rectal propranolol administration to steady-state in healthy volunteers: kinetics and beta-blockade. Clin. Pharmacol. Ther. 35 (1984) 148-156.
16. E. Cid, F. Mella, L. Lucchini, M. Cárcamo, J. Monasterio, Plasma concentrations and bioavailability of propranolol by oral, rectal and intravenous administration in man, Biopharmaceut. Drug Disp. 7 (1986) 559-566.
17. F. Moolenaar, J.P. Yska, J. Visser, D.K.F. Meijer, Drastic improvement in the rectal absorption profile of morphine in man, European J. Clin. Pharmacol. 29 (1985) 119-121.
18. M.R. Gregg, D.B. Jack, M.J. Kendall, The pharmacokinetics of oxprenolol following oral and rectal dosing - a comparison of delivery systems and routes of administration, J. Clin. Pharm. Therap. 12 (1987) 91-99.
19. H. Yoshikawa, S. Muranishi, C. Kato, H. Sezaki, Bifunctional delivery system for selective transfer of bleomycin into lymphatics via enteral route, Int. J. Pharmaceut. 8 (1981) 291-302.
20. H. Yoshikawa, Y. Satoh, N. Naruse, K. Takada, S. Muranishi, Comparison of disappearance from blood and lymphatic delivery of human fibroblast interferon in rat by different administration routes, J. Pharmacobio-Dynam. 8 (1985) 206-210.
21. Y. Kaji, K. Uekama, H. Yoshikawa, K. Takada, S. Muranishi, Selective transfer of 1-hexylcarbamoyl-5-fluorouracil into lymphatics by combination of β-cyclodexin polymer complexation and absorption promoter in the rat, Int. J. Pharmaceut. 24 (1985) 79-89.
22. L.J.J. de Leede, A.G. de Boer, D.D. Breimer, Rectal infusion of the model drug antipyrine with an osmotic delivery system, Biopharm. Drug Disp. 2 (1981) 131-136.
23. L.G.J. de Leede, A.G. de Boer, S.L. van Velzen, D.D. Breimer, Zero-order rectal delivery of theophylline in man with an osmotic system, J. Pharmacokin. Biopharm. 10 (1982) 525-537.
24. M.W.E. Teunissen, L.G.J. de Leede, J.K. Boeijinga, D.D. Breimer, Correlation between antipyrine metabolite formation and theophylline metabolism in humans after simultaneous single-dose administration and at steady state, J. Pharmacol. Exp. Therap. 233 (1985) 770-775.
25. M.W.E. Teunissen, C.H. Kleinbloesem, L.G.J. de Leede, D.D. Breimer, Influence of cimetidine on steady-state concentration and metabolite formation from antipyrine infused with a rectal osmotic mini pump, European J. Clin. Pharmacol. 28 (1985) 681-684.
26. C.H. Kleinbloesem, J. van Harten, L.G.J, de Leede, P. van Brummelen, D.D. Breimer, Nifedipine kinetics and dynamics during rectal infusion to steady state with an osmotic system, Clin. Pharmacol. Therap. 36 (1984) 396-401.
27. C.H. Kleinbloesem, P. van Brummelen, M. Danhof, H. Faber, J. Urquhart et al., Rate of increase in the plasma concentration of nifedipine as a major determinant of its hemodynamic effects in humans. Clin. Pharmacol. Therap., 1987, 41, 26-30.
28. E.J. van Hoogdalem, A.M. Stijnen, A.G. de Boer, D.D. Breimer, Rate-controlled absorption enhancement of rectally administered cefazolin in rats by a glyceride mixture (MGK), J. Pharm. Pharmacol. 40 (1988) 329-332.
29. E.J. van Hoogdalem, J.A.M. Geerts, A.G. de Boer, D.D. Breimer, The influence of MGK components on the rectal absorption of cefazolin in rats, J. Pharm. Pharmacol. 40 (1988) 815-817.
30. Y. Watanabe, E.J. van Hoogdalem, A.G. de Boer, D.D. Breimer, Absorption enhancement of rectally infused cefoxitin by medium chain monoglyderides in conscious rats, J. Pharm. Sci. 77(10) (1988) 847-849.
31. E.J. van Hoogdalem, M.A. Hardens, A.G. de Boer, D.D. Breimer, Absorption enhancement of rectally infused cefoxitin sodium by medium-chain fatty acids in conscious rats: concentration-effect relationship, Pharmaceut. Res. 5(7) (1988) 453-456.
32. E.J. van Hoogdalem, A.T.E. Wackwitz, A.G. de Boer, A.F. Cohen, D.D. Breimer, Rate-controlled rectal absorption enhancement of cefoxitin sodium salicylate and sodium octanoate in healthy volunteers, Br. J. Clin. Pharmacol. 27 (1989) 75-81.
33. E.J. van Hoogdalem, C. Vermeij-Keers, A.G. de Boer, D.D. Breimer, Topical effects absorption enhancing agents on the rectal mucosa in rats in vivo, J. Pharm. Sci. 79 (1990) 866-870.
34. W. Curatolo, R. Ochoa, Safety assessment of intestinal permeability enhancers, in: Drug Absorption Enhancement: Concepts, Possibilities, Limitations and Trends, Vol. 3 in the series of Drug Targeting and Delivery, A.G. de Boer (Ed.), Harwood Academic Publishers GmbH, Amsterdam, The Netherlands, p. 367-389.
35. E.J. van Hoogdalem, C.D. Heijligers-Feijen, R.A.A, Mathôt et al., Rectal absorption enhancement of cefoxitin and desglycinamide arginine vasopressin (DGAVP) by sodium tauro-24,25-dihydrofusidate (STDHF) in conscious rats, Pharmaceut. Res. 6 (1989) 91-95.
36. E.J. van Hoogdalem, C.D. Heijligers-Feijen, R.A.A. Mathôt et al., Rectal absorption enhancement of cefoxitin and desglycinamide arginine vasopressin (DGAVP) by sodium tauro-24,25-dihydrofusidate (STDHF) in conscious rats, J. Pharmacol. Exp. Therap. 251-252 (1989) 741-744.
37. W.H. Hollinshead, in: Anatomy for Surgeons, part II, P.B. Hoeber, (Ed.), New York, 1961