A novel chromosomal region of allelic loss, 4q32-q34, in human osteosarcomas revealed by representational difference analysis

Genes Chromosomes and Cancer

Volumn 26, Issue 2, 1999, Pages 115-124

  Simons, Annet ^a,c   Schepens, Marga ^a   Forus, Anne ^b   Godager, Linda ^b   Van Asseldonk, Martien ^a   Myklebost, Ola ^b   Van Kessel, Ad Geurts ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME 4Q; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; GENE ISOLATION; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; OSTEOSARCOMA; PRIORITY JOURNAL; SOUTHERN BLOTTING; TUMOR SUPPRESSOR GENE; TUMOR XENOGRAFT;

ANIMALS; BLOTTING, SOUTHERN; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 4; DNA, NEOPLASM; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LOSS OF HETEROZYGOSITY; MICE; MICE, NUDE; NUCLEIC ACID HYBRIDIZATION; OSTEOSARCOMA; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0032852132     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199910)26:2<115::AID-GCC3>3.0.CO;2-E     Document Type: Article

References (49)

1. Andreassen A, Øyjord T, Hovig E, Holm R, Flørenes VA, Nesland JM, Myklebost O, Høie J, Bruland OS, Borresen AL, Fodstad Ø. 1993. p53 abnormalities in different subtypes of human sarcomas. Cancer Res 53:468-471.
2. Biegel JA, Womer RB, Emanuel BS. 1989. Complex karyotypes in a series of pediatric osteosarcomas. Cancer Genet Cytogenet 38:89-100.
3. Casciola-Rosen L, Nicholson DW, Chong T, Rowan KR, Thornberry NA, Miller DK, Rosen A. 1996. Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death. J Exp Med 183:1957-1964.
4. Dib C, Faure S, Fizames C, Samson D, Drouot N, Vignal A, Millasseau P, Marc S, Hazan J, Seboun E, Lathrop M, Gyapay G, Morissette J, Weissenbach J. 1996. A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 380:152-154.
5. Dunne J, Hanby AM, Poulsom R, Jones TA, Sheer D, Chin WG, Da SM, Zhao Q, Beverley PCL, Owen MJ. 1995. Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-35 and encodes a putative adhesion molecule. Genomics 30:207-223.
6. Fisher RP, Morgan DO. 1994. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 78:713-724.
7. Fletcher JA, Gebhardt MC, Kozakewich HP. 1994. Cytogenetic aberrations in osteosarcomas. Cancer Genet Cytogenet 77:81-88.
8. Forus A, Flørenes VA, Maelandsmo GM, Metlzer PS, Fodstad Ø, Myklebost O. 1993. Mapping of amplification units in the q13-14 region of chromosome 12: some amplica do not include MDM2. Cell Growth Differ 4:1065-1070.
9. Forus A, Olde Weghuis D, Smeets D, Fodstad Ø, Myklebost O, Geurts van Kessel A. 1995a. Comparative genomic hybridization of human sarcomas. I. Occurence of genomic imbalances and identification of a novel major amplicon at 1q21-q22 in soft tissue sarcomas. Genes Chromosomes Cancer 14:8-14.
10. Forus A, Olde Weghuis D, Smeets D, Fodstad Ø, Myklebost O, Geurts van Kessel A. 1995b. Comparative genomic hybridization of human sarcomas. II. Identification of novel amplicons at 6p and 17p in osteosarcomas. Genes Chromosomes Cancer 14:15-21.
11. Forus A, Berner J-M, Meza-Zepeda LA, Saeter G, Mischke D, Fodstad Ø, Myklebost O. 1998. Molecular characterization of a novel amplicon at 1q21-q22 frequently observed in human sarcomas. Br J Cancer 78:495-503.
12. Geurts van Kessel A, dos Santos N, Simons A, de Bruijn D, Forus A, Fodstad O, Myklebost O, Balemans M, Baats E, Olde Weghuis D, Suijkerbuijk RF, de Leeuw B. 1997. Molecular cytogenetics of bone and soft tissue tumors. Cancer Genet Cytogenet 95:67-73.
13. Hammoud ZT, Kaleem Z, Cooper JD, Sudhir Sundaresan R, Alexander Patterson G, Goodfellow PJ. 1996. Allelotype analysis of esophageal adenocarcinomas: evidence for the involvement of sequences on the long arm of chromosome 4. Cancer Res 56:4499-4502
14. Heim S, Mitelman F. 1995. Cancer Cytogenetics, 2nd ed. New York: Wiley-Liss, p 476-513.
15. Hoogerwerf WA, Hawkins AL, Perlman EJ, Griffin CA. 1994. Chromosome analysis of nine osteosarcomas. Genes Chromosomes Cancer 9:88-92
16. Huang LS, Bock SC, Feinstein SI, Breslow JL. 1985. Human apolipoprotein B mRNA is 22 kilo bases in length. Proc Natl Acad Sci USA 82:6825-6829.
17. Kallioniemi A, Kallioniemi O-P, Sudar D, Rutovitz D, Gray JW, Waldman F, Pinkel D. 1992. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 258:818-821.
18. Kallioniemi O-P, Kallioniemi A, Piper J, Isola J, Waldman F, Gray JW, Pinkel D. 1994. Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors. Genes Chromosomes Cancer 10:231-243.
19. Kerstens HMJ, Poddighe PJ, Hanselaar AGJM. 1995. A novel in situ hybridization signal amplification method based on the deposition of biotinylated tyramine. J Histochem Cytochem 43:347-352.
20. Kruzelock RP, Murphy EC, Strong LC, Naylor SL, Hansen MF. 1997. Localization of a novel tumor suppressor locus on human chromosome 3q important in osteosarcoma tumorigenesis. Cancer Res 57:106-109.
21. Ladanyi M, Cha C, Lewis R, Jhanwar SC, Huvos AG, Healey JH. 1993. MDM2 gene amplification in metastatic osteosarcoma. Cancer Res 53:16-18.
22. Larson AA, Liao S-Y, Stanbridge EJ, Cavenee WK, Hampton GM. 1997. Genetic alterations accumulate during cervical tumorigenesis and indicate a common origin for multifocal lesions. Cancer Res 57:4171-1176.
23. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McComie R, Bigner SH, Giovanella BC, Ittman M, Tycko B, Hibshoosh H, Wigler MH, Parsons R. 1997. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275:1943-1947.
24. Lisitsyn N. 1995. Representational difference analysis: finding the differences between genomes. Trends Genet 11:303-307.
25. Lisitsyn N, Lisitsyn N, Wigler M. 1993. Cloning the difference between two complex genomes. Science 259:946-951.
26. Lisitsyn NA, Lisitsina NM, Dalbagni G, Barker P, Sanchez CA, Gnarra J, Marston Linehan W, Reid BJ, Wigler MH. 1995. Comparative genomic analysis of tumors: detection of DNA losses and amplification. Proc Natl Acad Sci USA 92:151-155.
27. Loughran O, Clark LJ, Bond J, Baker A, Berry IJ, Edington KG, Ly I-S, Simmons R, Haw R, Black DM, Newbold RF, Parkinson EK. 1997. Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes. Oncogene 14:1955-1964.
28. Mertens F, Mandahl N, Örndal C, Baldetorp B, Bauer HCF, Rydholm A, Wiebe T, Willén H, Åkerman M, Heim S, Mitelman F. 1993. Cytogenetic findings in 33 osteosarcomas. Int J Cancer 55:44-50.
29. Miller CW, Aslo A, Tsay C, Slamon D, Ishizaki K, Toguschida J, Yamamuro T, Lampkin B, Koeffler HP. 1990. Frequency and structure op p53 rearrangements in human ostcosarcoma. Cancer Res 50:7950-7954.
30. Mulligan LM, Matlashewski GJ, Scrable HJ, Cavenee WK. 1990. Mechanism of p53 loss in human sarcoma. Proc Natl Acad Sci USA 87:5863-5867.
31. Nellissery M, Padalecki SS, Brkanac Z, Singer FR, David Roodman G, Krishnan Unni K, Leach RJ, Hansen MF. 1998. Evidence for a novel osteosarcoma tumor-suppressor gene in the chromosome 18 region genetically linked with Paget disease of bone. Am J Hum Genet 63:817-824.
32. Ozaki T, Ikeda S, Kawai A, Inoue H, Oda T. 1993. Alterations of retinoblastoma susceptibility gene accompanied by c-MYC amplification in human bone and soft tissue tumors. Mol Cell Biol 39:235-242.
33. Pershouse MA, El-Naggar A, Hurr K, Lin H, Yung WKA, Steck PA. 1997. Deletion mapping of chromosome 4 in head and neck squamous cell carcinoma. Oncogene 14:369-373.
34. Piao Z, Park C, Park J-H, Kim H. 1998. Allelotype analysis of hepatocellular carcinoma. Int J Cancer 75:29-33.
35. Polascik TJ, Cairns P, Chang WYH, Schoenberg MP, Sidransky D. 1995. Distinct regions of allelic loss on chromosome 4 in human primary bladder carcinoma. Cancer Res 55:5396-5399.
36. Raap AK, van de Corput MPC, Vervenne RAW, van Gijlswijk RPM, Tanke HJ, Wiegant J. 1995. Ultra-sensitive FISH using peroxidase-mediated deposition of biotin-or fluorochrome tyramides. Hum Mol Genet 4:529-534.
37. Sambrook J, Fritsch EF, Maniatis T. 1989. Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
38. Sandberg AA, Bridge JA. 1994. The Cytogenetics of Bone and Soft Tissue Tumors. Austin: R.G. Landes Company, p 343-370.
39. Schutte M, da Costa LT, Hahn SA, Moskaluk C, Shamsul Hoque ATM, Rozenblum E, Weinstein CL, Bittner M, Meltzer PS, Trent JM, Yeo CJ, Hruban RH, Kern SE. 1995. Identification by representational difference analysis af a homozygous deletion in pancreatic carcinoma that lies within the BRCA2 region. Proc Natl Acad Sci USA 92:5950-5954.
40. Simons A, Janssen IM, Suijkerbuijk RF, Veth RPH, Pruszczynski M, Hulsbergen-van de Kaa CA, du Manoir S, Geurts van Kessel A. 1997. Isolation of osteosarcoma-associated amplified DNA sequences using representational difference analysis. Genes Chromosomes Cancer 20:196-200.
41. Simons A, Jeuken JWM, Eleveld MJ, Boerman RH, Geurts van Kessel A. 1999. Isolation and characterisation of glioblastoma-associated homozygously deleted DNA fragments from chromosomal region 9p21 suggests involvement of multiple tumour suppressor genes. J Pathol (in press).
42. Suijkerbuijk RF, Sinke RJ, Olde Weghuis DEM, Roque L, Forus A, Stellink F, Siepman A, van de Kaa C, Soares J, Geurts van Kessel A. 1994. Amplification of chromosome 12p11.2-p12.1 in a metastasis of an i(12p)-negative seminoma: relationship to tumor progression? Cancer Genet Cytogenet 78:145-152.
43. Tarkkanen M, Kaipainen A, Karaharju E, Böhling T, Szymanska J, Heliö H, Kivioja A, Elomaa I, Knuutila S. 1993. Cytogenetic study of 249 consecutive patients examined for a bone tumor. Cancer Genet Cytogenet 68:1-21
44. Tarkkanen M, Karhu R, Kallioniemi A, Elomaa I, Kivioja AH, Nevalainen J, Böhling T, Karaharju E, Hyytinen E, Knuutila S, Kallioniemi O-P. 1995. Gains and losses of DNA sequences in osteosarcomas by comparative genomic hybridization. Cancer Res 55:1334-1338.
45. Toguschida J, Ishizaki K, Sasaki MS, Ikenaga M, Sugimoto M, Kotoura Y, Yamamuro T. 1988. Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in development of osteosarcoma. Cancer Res 48:3939-3943.
46. Vaughan PS, Aziz F, van Wijnen AJ, Wu S, Harada H, Taniguchi T, Soprano KJ, Stein JL, Stein GS. 1995. Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2. Nature 377:362-365.
47. Vocero-Akbani A, Helms C, Wang JC, Sanjurjo FJ, Korte-Sarfaty J, Veile RA, Liu L, Jauch A, Burfess AK, Hing AV, Holt MS, Ramachandra S, Whelan AJ, Anker R, Ahrent L, Chen M, Gavin MR, Iannantuoni K, Morton SM, Pandit SD, Read CM, Steinbrueck T, Warlick C, Smoller DA, Donis-Keller H. 1996. Mapping human telomere regions with YAC and P1 clones: chromosome-specific markers for 27 telomeres including 149 STSs and 24 polymorphisms for 14 proterminal regions. Genomics 36:492-506.
48. Wadayama B, Toguschida J, Shimizu T, Ishizaki K, Kotoura Y, Yamamoto T. 1994. Mutation spectrum of the retinoblastoma gene in osteosarcoma. Cancer Res 54:3042-3048.
49. Weiner KX, Ciesla J, Jaffe AB, Ketring R, Maley F, Maley GF. 1995. Chromosomal location and structural organization of the human deoxycytidylate deaminase gene. J Biol Chem 270:18727-18729.