Bioavailability of starch based hot stage extrusion formulations

International Journal of Pharmaceutics

Volumn 187, Issue 2, 1999, Pages 185-191

  Henrist, D ^a   Lefebvre, R A ^b   Remon, J P ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Hot stage extrusion; In vivo; Starch; Sustained release matrix; Theophylline

Indexed keywords

GELATIN; GLYCEROL STEARATE; SORBITOL; STARCH; THEOPHYLLINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD LEVEL; CALIBRATION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CAPSULE; DRUG DETERMINATION; DRUG MANUFACTURE; DRUG RELEASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE; TECHNIQUE; ULTRAVIOLET SPECTROPHOTOMETRY; XANTHIUM;

ADULT; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CROSS-OVER STUDIES; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; HUMANS; MALE; STARCH; THEOPHYLLINE;

EID: 0032851618     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00186-6     Document Type: Article

References (20)

1. Breitenbach, J., Grabowski, S., Rosenberg, J., 1995. Extrusion von Polymer-Wirkstoff-Gemischen zur Herstellung von Arzneiformen. Spektrum der Wissenschaft, July, 18-20.
2. Carr, M.E., Wing, R.E., Doane, W.M., 1994. Clay as a carrier in starch encapsulated herbicides prepared by extrusion processing. Starch/Stärke 46, 9-13.
3. De Bock, I.L.H.A., Van Den Broecke, P.M., Bahr, K.-H., 1993. European Patent EP 0 599 535 A1, 17 Nov.
4. De Bock, I.L.H.A., Van Den Broecke, P.M., Bahr, K.-H., 1994. European Patent EP 0 609 983 A2, 12 Jan.
5. Doane, W.M., 1992. USDA research on starch-based biodegradable plastics. Starch/Stärke 44, 293-295.
6. Follonier, N., Doelker, E., Cole, E.T., 1994. Evaluation of hot-melt extrusion as a new technique for the production of polymer-based pellets for sustained release capsules containing high loadings of freely soluble drugs. Drug Dev. Ind. Pharm. 20, 1323-1339.
7. Follonier, N., Doelker, E., Cole, E.T., 1995. Various ways of modulating the release of diltiazem hydrochloride from hot-melt extruded sustained release pellets prepared using polymeric materials. J. Control. Rel. 36, 243-250.
8. Fritz, H.-G., Widmann, B., 1993. Der einsatz von stärke bei der modifizierung synthetischer kunststoffe. Starch/Stärke 45, 314-322.
9. Gruenhagen, H.H., 1996. Polymer/drug-melt extrusion: therapeutic and technological appeal. Pharm. Tech. Europe 8, 22-28.
10. Krishnan, P.G., Julson, J.L., Robison, D.J., Pathak, Y.V., 1994. Polyethylene-starch extrudates as erodible carriers for bioactive materials: I. erodibility and in vitro dye release studies. In: Kohudic, M.A. (Ed.), Advances in Controlled Delivery of Drugs. Technomic Publishing Company, Basel, pp. 59-71.
11. Launay, B., Lisch, J.M., 1983. Twin-screw extrusion cooking of starches: flow behaviour of starch pastes, expansion and mechanical properties of extrudates. J. Food Eng. 2, 259-280.
12. Mank, R., Kala, H., Richter, M., 1989. Darstellung wirkstoffhaltiger extrusionsformlinge auf der basis von thermo-plasten. Teil 1: Untersuchungen zur wirkstoffliberation. Pharmazie 44, 773-776.
13. Mank, R., Kala, H., Richter, M., 1990. Darstellung wirkstoffhaltiger extrusionsformlinge auf der basis von thermoplasten. Teil 2: Untersuchungen zur Optimierung der wirkstofffreigabe. Pharmazie 45, 592-593.
14. Mueller, W., Spengler, R., Grabowski, S., Sanner, A., 1992. European Patent EP 0 544 144 B1, 11 Nov.
15. Schreiber, M.M., Hickman, M.V., Vail, G.D., 1994. Efficacy of starch-encapsulated formulations of atrazine containing two or three herbicides in same granule. Weed Technol. 8, 105-113.
16. Shogren, R.L., Fanta, G.F., Doane, W.M., 1993. Development of starch based plastics - a reexamination of selected polymer systems in historical perspective. Starch/Stärke 45, 276-280.
17. Sprockel, O.L., Sen, M., Shivanand, P., Prapaitrakul, W., 1997. A melt-extrusion process for manufacturing matrix drug delivery systems. Int. J. Pharm. 155, 191-199.
18. Steinijans, V.W., 1990. Pharmacokinetic characterization of controlled-release formulations. Eur. J. Drug Metab. Pharmacokinet. 15, 173-181.
19. Vandenbossche, G.M.R., Lefebvre, R.A., De Wilde, G.A., Remon, J.P., 1992. Performance of a modified starch hydrophilic matrix for the sustained release of theophylline in healthy volunteers. J. Pharm. Sci. 81, 245-248.
20. van Zuilichem, D.J., 1992. Extrusion cooking: craft or science? Ph.D Thesis, Landbouwuniversiteit Wageningen, the Netherlands, pp. 3-6.