A melt-extrusion process for manufacturing matrix drug delivery systems

International Journal of Pharmaceutics

Volumn 155, Issue 2, 1997, Pages 191-199

  Sprockel, Omar L ^b   Sen, Mahua ^a   Shivanand, Padmaja ^a   Prapaitrakul, Waruwan ^c  

^a UNIVERSITY OF CINCINNATI   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c PFIZER INC   (United States)

Author keywords

Diffusion; Drug release; Matrix; Melt extrusion; Percolation theory; Polycaprolactone; Polyethylene; Polymer; Soluble additives

Indexed keywords

CELLABURATE; CHLORPHENIRAMINE MALEATE; MACROGOL DERIVATIVE; POLYCAPROLACTONE; POLYETHYLENE; POLYMER; POLYVINYL ACETATE; SALICYLIC ACID; THEOPHYLLINE; UNCLASSIFIED DRUG;

ARTICLE; DIFFUSION; DIFFUSION COEFFICIENT; DISSOLUTION; DRUG DELIVERY SYSTEM; DRUG RELEASE; MATRIX TABLET; PARTICLE SIZE; PRIORITY JOURNAL;

EID: 0030880625     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00165-8     Document Type: Article

References (21)

1. Agabeyoglu I. Studies on sustained release I: The biopharmaceutical design and production of an inert matrix type sulfamethizole tablet, employing polymethyl methacrylate. Drug Dev. Ind. Pharm. 11:1985;2021-2041.
2. Ahmed M., Enever R. Formulation and evaluation of sustained release paracetamol tablets. J. Clin. Hosp. Pharm. 6:1981;27-37.
3. Cobby J., Mayersohn M., Walker G. Influence of shape factors on kinetics of drug release from matrix tablets I: Theoretical. J. Phar. Sci. 63:1974;725-732.
4. Fassihi A., Parker M. Controlled drug release from a compressed heterogeneous polymeric matrix: kinetics of release. Drug Dev. Ind. Pharm. 12:1986;1649-1661.
5. Fassihi A., Parker M., Pourkavous N. Solid dispersion controlled release: Effect of particle size, compression force and temperature. Drug Dev. Ind. Pharm. 11:1985;523-535.
6. Flanders P., Dyer G.A., Jordan D. The control of drug release from conventional melt granulation matrices. Drug Dev. Ind. Pharm. 13:1987;1001-1022.
7. deHaan P., Lerk C. The megaloporous system: a novel principle for zero-order drug delivery I. In vitro and in vivo performance. Int. J. Pharm. 31:1986;15-24.
8. Hashem F., El-Dien E.E.Z. Controlled release salbutamol sulphate molded tablets using Eudragit retard. Drug Dev. Ind. Pharm. 16:1990;541-549.
9. Hastedt J.E., Wright J.L. Diffusion in porous materials above the percolation threshold. Pharm. Res. 7:1990;893-901.
10. Higuchi T. Mechanism of sustained action medication. J. Pharm. Sci. 52:1963;1145-1149.
11. Maxwell B. Miniature injection molder minimizes resident time. SPE J. 28:1972;24-27.
12. McTaggart C., Canley J., Sickmueller A., Walker J. The evaluation of formulation and processing conditions of a melt granulation process. Int. J. Pharm. 19:1984;139-148.
13. Mulley I., Bardon J., Rollet M., Taverdet J., Vergnaud J. Modelling of controlled drug release in case of carbopol-sodium salicylate in gastric liquid. Drug Dev. Ind. Pharm. 13:1987;67-79.
14. Onay-Basaran S., Olsen J. Formulation of long-acting quinacrin hydrochloride pellets in different matrices I. Drug Dev. Ind. Pharm. 11(12):1985;2143-2154.
15. Parab P., Oh C., Ritschel W. Sustained release from precirol (glycerol palmito-stearate) matrix. Effect of mannitol and hydroxypropyl methylcellulose on the release of theophylline. Drug Dev. Ind. Pharm. 12:1980;1309-1327.
16. Prapaitrakul W., Sprockel O.L., Shivanand P. Release of chlorpheniramine maleate from fatty acid ester matrix disks prepared by melt-extrusion. J. Pharm. Pharmacol. 43:1990;377-381.
17. Said S., Al-Shora H. Sustained release from inert matrices. I. Effect of microcrystalline cellulose on aminophylline and theophylline release. Int. J. Pharm. 6:1980;11-18.
18. Saltzman W.M., Langer R. Transport rates of proteins in porous materials with known microgeometry. Biophys. J. 55:1989;163-171.
19. Siegel R.A., Langer R. Mechanistic studies of macromolecular drug release from macroporous polymers. II. models for the slow kinetics of drug release. J. Control. Release. 8:1989;153-167.
20. Siegel R.A., Kost J., Langer R. Mechanistic studies of macromolecular drug release from macroporous polymers. I. Experiments and preliminary theory concerning completeness of drug release. J. Control. Release. 8:1989;223-236.
21. Stauffer, D., 1985. Introduction to Percolation Theory. Taylor & Francis, London, England.