Characterization of the major susceptibility region for psoriasis at chromosome 6p21.3

Journal of Investigative Dermatology

Volumn 113, Issue 3, 1999, Pages 322-328

  Balendran, Nalini ^a   Clough, R Lee ^b   Arguello, J Rafael ^c   Barber, Ruth ^b   Veal, Colin ^b   Jones, Andrew B ^d   Rosbotham, Jane L ^d   Little, Anne Margaret ^c   Madrigal, Alejandro ^c   Barker, Jonathan N W N ^d   Powis, Stephen H ^a   Trembath, Richard C ^b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c ROYAL FREE HOSPITAL   (United Kingdom)

^d ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Human leukocyte antigen; Linkage; Major histocompatibility complex

Indexed keywords

ARTICLE; CHROMOSOME 6P; FAMILY STUDY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HLA SYSTEM; HUMAN; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PSORIASIS;

EID: 0032851551     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.1999.00710.x     Document Type: Article

References (47)

1. Arguello JR, Little AM, Pay AL, et al: Mutation detection and typing of polymorphic loci through double-strand conformation analysis. Nat Genet 18:192-194, 1998
2. Barker JN: The pathophysiology of psoriasis. Lancet 338:227-230, 1991
3. Bodmer JG, Marsh SGE, Albert ED, et al: Nomenclature for factors of the HLA system. Tissue Antigens 49:297-321, 1996
4. Brandrup F, Holm N, Grunnet N, Henningsen K, Hansen HE: Psoriasis in monozygotic twins: variations in expression in individuals with identical genetic constitution. Acta Derm Venereol (Stockh) 62:229-236, 1982
5. Brenner W, Gschnait F, Mayr WR: HLA B13, B17, B37 and Cw6 in psoriasis vulgaris: association with the age of onset. Arch Dermatol Res 262:337-339, 1978
6. Browning M, McMichael A: HLA and MHC: Genes Molecules and Function Oxford: BIOS Scientific, 1996
7. Burden AD, Javed S, Bailey M, Hodgins M. Connor M, Tillman D: Genetics of psoriasis: paternal inheritance and a locus on chromosome 6p. J Invest Dermatol 110:958-960, 1998
8. Camp RDR. Psoriasis. In: Champion RH, Burton JL, Burns DA, Breathnach SM (eds). Textbook of Dermatology Oxford: Blackwell Science, 1998, pp 1589-1649
9. Cao K, Song FJ, Li HG, Xu SY, Liu ZH, Su XH, Wang FX: Association between HLA antigens and families with psoriasis vulgaris. Chin Med J 106:132-135, 1993
10. Capon F, Novelli G, Semprini, S, et al: Searching for psoriasis susceptibility genes in Italy: genome scan and evidence for a new locus on chromosome 1. J Invest Dermatol 112:32-35, 1999
11. Dib C, Faure S, Fizames C, et al: A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 380:152-154, 1996
12. Economidou J, Papasteriades C, Varla-Leftherioti M, Vareltzidis A, Stratigos J: Human lymphocyte antigens A, B, and C in Greek patients with psoriasis: relation to age and clinical expression of the disease. J Am Acad Dermatol 13:578-582, 1985
13. Feder JN, Gnirke A, Thomas W et al: A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 13:399-408, 1996
14. Foissac A, Cronau Roy B, Faure S, Thomsen M. Cambon-Thomsen A: Microsatellites in the HLA region: on overview. Tissue Antigens 49:197-214, 1997
15. Goldsworthy M, Sampath A, Wilkinson JM, Powis SH: Identification of new class I region genes by sample sequencing. Immunogenetics 46:206-212, 1997
16. Groh V, Bahram S, Bauer S, Herman A, Beauchamp M, Spies T: Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc Natl Acad Sci USA 93:12445-12450, 1996
17. Hsieh SL, March RE, Khanna A, Cross SJ, Campbell RD: Mapping of 10 novel microsatellites in the MHC class III region: application to the study of autoimmune disease. J Rheumatol 24:220-222, 1997
18. Ishihara M, Yamagata N, Ohno S, et al: Genetic polymorphisms in the keratin-like S gene within the human major histocompatibility complex and association analysis on the susceptibility to psoriasis vulgaris. Tissue Antigens 48:182-186, 1996
19. Jenisch S, Henseler T, Nair RP, et al: Linkage analysis of human leukocyte antigen (HLA) markers in familial psoriasis: strong disequilibrium effects provide evidence for a major determinant in the HLA-B/-C region. Am J Hum Genet 63:191-199, 1998
20. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES: Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-1363, 1996
21. Lako M, Ramsden S, Campbell RD, Strachan T: Mutation screening in British 21-hydroxylase deficiency families and development of novel microsatellite based approaches to prenatal diagnosis. J Med Genet 36:119-124, 1999
22. Lomholt G: Psoriasis: Prevalence, Spontaneous Course and Genetics. Copenhagen: GEC Gad, 1963
23. Marshall B, Tay G, Marley J, Abraham LJ, Dawkins RL: Analysis of MHC genomic structure and gene content between HLA-B and TNF using yeast artificial chromosomes. Genomics 17:435-441, 1993
24. Martin MP, Harding A, Chadwick R, et al: Characterization of 12 microsatellite loci of the human MHC in a panel of reference cell. Immunogenetics 47:131-138, 1998
25. Matthews D, Fry L, Powles A, et al: Evidence that a locus for familial psoriasis maps to chromosome 4q. Nat Genet 14:231-233, 1996
26. Nair RP, Henseler T, Jenisch S, et al: Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan. Hum Mol Genet 6:1349-1356, 1997
27. Ozawa A, Ohkido M, Inoko H, Ando A, Tsuji K: Specific restriction fragment length polymorphism on the HLA-C region and susceptibility to psoriasis vulgaris. J Invest Dermatol 90:402-405, 1988
28. Pitchappan RM, Koteeswaran A, Kakkaniah VN, et al: HLA Bw57 and DR7 association with psoriasis vulgaris in south India. Tissue Antigens 34:133-137, 1989
29. Reed PW, Davies JL, Copeman JB, et al: Chromosome-specific microsatellite sets for fluorescence-based, semi-automated genome mapping. Nat Genet 7:390-395, 1994
30. Russell TJ, Schultes LM, Kuban DJ: Histocompatibility (HL-A) antigens associated with psoriasis. N Engl J Med 287:738-740, 1972
31. Satsangi J, Parkes M, Louis E, et al: Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nat Genet 14:199-202, 1996
32. Schaid DJ, Sommer SS: Comparison of statistics for candidate-gene association studies using cases and parents. Am J Hum Genet 55:402-409, 1994
33. Schmitt-Egenolf M, Eiermann TH, Boehncke WH, Stander M, Sterry W: Familial juvenile onset psoriasis is associated with the human leukocyte antigen (HLA) class I side of the extended haplotype Cw6-B57-DRB1*0701-DQA1*0201DQB1*0303: a population- and family-based study. J Invest Dermatol 106:711-714, 1996
34. Spielman RS, Ewens WJ: The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 59:983-989, 1996
35. Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 52:506-516, 1993
36. Svejgaard A, Nielsen LS, Svejgaard E, Nielsen FK, Hjortshoj A, Zachariac H: HLA in psoriasis vulgaris and in pustular psoriasis-population and family studies. Br J Dermatol 91:145-153, 1974
37. Terwilliger JD: A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci. Am J Hum Genet 56:777-787, 1995
38. Theeuwes M, Leder R: Hereditary insights in psoriasis. Eur J Dermatol 3:335-341, 1993
39. Thomson G; Mapping disease genes: family-based association studies. Am J Hum Genet 57:487-498, 1995
40. Tiwari JL, Terasaki PI: HLA and Disease Associations. New York: Springer Verlag, 1985
41. Tomfohrde J, Silverman A, Barnes R, et al: Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q. Science 264:1141-1145, 1994
42. Trembath RC, Clough RL, Rosbotham JL, et al: Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis. Hum Mol Genet 6:813-820, 1997
43. Wei H, Fan WF, Xu H, Parimoo S, Shukla H, Chaplin DO, Weissman SM: Genes in one megabase of the HLA class I region. Proc Natl Acad Sci USA 90:11870-11874, 1993
44. White SH, Newcomer VD, Mickey MR, Terasaki PI: Disturbance of HL-A antigen frequency in psoriasis. N Engl J Med 287:740-743, 1972
45. Yoshida M, Kimura A, Numano F, Sasazuki T: Polymerase-chain-reaction-based analysis of polymorphism in the HLA-B gene. Hum Immunol 34:257-266, 1992
46. Zhou Y, Chaplin DD: Identification in the HLA class I region of a gene expressed late in keratinocyte differentiation. Proc Natl Acad Sci USA 90:9470-9474, 1993
47. Zwirner NW, Fernandez-Vina MA, Stastny P: MICA, a new polymorphic HLA-related antigen, is expressed mainly by keratinocytes, endothelial cells, and monocytes. Immunogenetics 47:139-148, 1998