Gadolinium-containing copolymeric chelates - A new potential MR contrast agent

Magnetic Resonance Materials in Physics, Biology and Medicine

Volumn 8, Issue 3, 1999, Pages 154-162

  Unger, Evan C ^a   Shen, Dekang ^a   Wu, Guanli ^a   Stewart, Leah ^a   Matsunaga, Terry O ^a   Trouard, Theodore P ^b  

^a ImaRx Therapeutics Inc   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Blood pool; Chelates; Gadolinium; MR contrast agents; Polymers

Indexed keywords

CHELATE; CONTRAST MEDIUM; COPOLYMER; GADOLINIUM; GLYCOL; MACROGOL; PENTETIC ACID; POLYPROPYLENE;

ATOMIC ABSORPTION SPECTROMETRY; CONFERENCE PAPER; CONTRAST ENHANCEMENT; MAGNETIC RESONANCE ANGIOGRAPHY; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

ANIMALS; CHELATING AGENTS; CONTRAST MEDIA; GADOLINIUM DTPA; IMAGE ENHANCEMENT; MAGNETIC RESONANCE ANGIOGRAPHY; MAGNETIC RESONANCE IMAGING; MOLECULAR WEIGHT; PENTETIC ACID; POLYETHYLENE GLYCOLS; POLYMERS; PROPYLENE GLYCOLS; RABBITS; WATER;

ORYCTOLAGUS CUNICULUS;

EID: 0032851518     PISSN: 13528661     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1352-8661(99)00024-1     Document Type: Conference Paper

References (25)

1. Blustajn J., Cuenod C.-A., Clement O., Siauve N., Vuillemin-Bodaghi V., Frija G. Measurement of liver blood volume using a macromolecular MRI contrast agent at equilibrium. Mag Res Imaging. 15(4):1997;415-421.
2. Shames D., Kuwatsuru R., Vexler V., Mühler A., Brasch R. Measurement of capillary permeability to macromolecules by dynamic magnetic resonance imaging: a quantitative noninvasive technique. Magn Reson Med. 29:1993;616-622.
3. Demsar F., Roberts T.P.L., Schwickert H.C., Shames D.M., van Dijke C.F., Mann J.S., Saeed M., Brasch R.C. An MRI spatial mapping technique for microvascular permeability and tissue blood volume based on macromolecular contrast agent distribution. Magn Reson Med. 37:1997;236-242.
4. Brasch R.C. Rationale and applications for macromolecular Gd-based contrast agents. Magn Reson Med. 22:1991;282-287.
5. Weinmann H.J., Laniado M., Mutzel W. Pharmacokinetics of Gd-DTPA/dimeglumine after intravenous injection into healthy volunteers. Physiol Chem Phys Med NMR. 16:1988;167-178.
6. -2 and Gd(DOTA) and Gd(acetate) in mice. Int J Rad Appl Inst. 15:1988;395-401.
7. Weinmann H.J., Brasch R.C., Press W.R., Wesby G.E. Characteristics of gadolinium-DTPA complex: a potential NMR contrast agents. Am J Roentgenol. 142:1984;619-624.
8. Brasch R.C., Weinmann H.J., Wesbey G.E. Contrast enhanced NMR imaging: animal studies using gadolinium-DTPA complex. Am J Roentgenol. 142:1984;625-630.
9. Unger E.C., Schilling J.D., Bernhard V.M., Awad A.N., McIntrye K.E., Yoshino M.T., Pond G.D., Darkazanli A., Hunter G.C. Magnetic resonance angiography of the foot and ankle. J Magn Reson Imaging. 5:1995;1-5.
10. Wagnon B.K., Jackels S.C. Synthesis, characterization, and aqueous proton relaxation enhancement of a manganese (II) heptaaza macrocyclic complex having pendant arms. Inorg Chem. 28(10):1987;1923-1927.
11. Burton D.R., Forsen S., Karlstrom G., Dwek R.A. Proton relaxation enhancement (PRE) in biochemistry: a critical survey. Prog NMR Spectrosc. 13(1):1979;1-45.
12. In: U.S. Pharmacopeia/National Formulary (USP XXII/NF XVII). United States Pharmacopeial Convention, Inc., Rockville, MD 1990.
13. Shen D., Fritz T.A., Wu G., Kulik B., Palestrant D., Unger E.C. Block copolymer magnetic resonance contrast agents. Invest Radiol. 29(Suppl 2):1994;S217-S219.
14. Shen D., Unger E.C., Wu G., Fritz T.A., Kulik B., New T.E. Copolymeric MR Contrast Agents. 1992;Society of Magnetic Resonance Imaging, New York. Abstract.
15. Unger EC, Wu G. Copolymers and Their Use as Contrast Agents in Magnetic Resonance Imaging and in Other Applications. U.S. Patent 5,385,719. Filed September 22, 1992. Issued January 31, 1995.
16. Unger EC, Wu G. Copolymers and Their Use as Contrast Agents in Magnetic Resonance Imaging and in Other Applications. U.S. Patent 5,458,127. Filed September 13, 1994. Issued October 17, 1995.
17. Unger EC, Wu G. Copolymers and Their Use as Contrast Agents in Magnetic Resonance Imaging and in Other Applications. U.S. Patent 5,517,993. Filed June 7, 1995. Issued May 21, 1996.
18. Snow RA, Ladd DL, Toner JL. Polyalkylene Oxide Polymer Conjugates with Chelating Agents for Therapeutic and Diagnostic Imaging Compositions and Methods. PCT publication WO 94/08624.
19. Elizondo G., Fretz C.J., Stark D.D., Rocklage S.M., Quay S.C., Worah D., Tsang Y.-M., Chen M.C.-M., Ferrucci J.T. Preclinical evaluation of MnDPDP: new paramagnetic hepatobiliary contrast agent for MR imaging. Radiology. 178:1991;73-78.
20. Mena I. Manganese. Disorders of Mineral Metabolism. 1:1981;233-270 Academic Press, Orlando, FL.
21. Keen C.L., Lonnerdal B. Manganese toxicity in man and experimental animals. Schramm V.L., Wedler F.C. Manganese in Metabolism and Enzyme Function. 1986;35-47 Academic Press, Orlando, FL.
22. Misselwitz B., Mühler A., Weinmann H.-J. A toxicologic risk for using manganese complexes? a literature survey of existing data through several medical specialties. Invest Radiol. 30(10):1995;611-620.
23. Sur S.K., Bryant R.G. Nuclear- and electron-spin relaxation rates in symmetrical iron, manganese, and gadolinium ions. J Phys Chem. 99(17):1995;6301-6308.
24. Kellar K.E., Henrichs P.M., Hollister R., Koenig S.H., Eck J., Wei D. High relaxivity linear Gd(DTPA)-polymer conjugates: the role of hydrophobic interactions. Mag Res Med. 38(5):1997;712-716.
25. Lester C.C., Bryant R.G. Magnetically coupled paramagnetic relaxation agents. Magn Res Med. 24:1992;236-242.