Effects of levobupivacaine, bupivacaine, and ropivacaine on tail-flick response and motor function in rats following epidural or intrathecal administration

Regional Anesthesia and Pain Medicine

Volumn 24, Issue 5, 1999, Pages 444-452

  Kanai, Yuko ^a   Tateyama, Shingo ^a   Nakamura, Tadashi ^a   Kasaba, Toshiharu ^a   Takasaki, Mayumi ^a  

^a UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

Enantiomer; Epidural; Intrathecal; Levobupivacaine; Local anesthetics; Ropivacaine

Indexed keywords

BUPIVACAINE; ROPIVACAINE;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CARDIOVASCULAR EFFECT; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG EFFICACY; EPIDURAL DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; LATENT PERIOD; MALE; MOTOR NERVE BLOCK; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; RAT; TAIL FLICK TEST;

EID: 0032848732     PISSN: 0146521X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00115550-199924050-00013     Document Type: Article

References (30)

1. Åberg G. Toxicological and local anaesthetic effects of optically active isomers of two local anaesthetic compounds. Acta Pharmacol Toxicol 1972: 31: 272-286.
2. Huang YF, Pryor ME, Mather LE, Veering BT. Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep. Anesth Analg 1998: 86: 797-804.
3. Bardsley H, Gristwood R, Baker H, Watson N, Nimmo W. A comparison of the cardiovascular effects of levobupivacaine and rac-bupivacaine following intravenous administration to healthy volunteers. Br J Clin Pharmacol 1998: 46: 245-249.
4. Lee-Son S, Wang GK, Concus A, Grill E, Strichartz GR. Stereoselective inhibition of neuronal sodium channels by local anesthetics. Anesthesiology 1992: 77: 324-335.
5. Valenzuela C, Snyders DJ, Bennett PB, Tamargo J, Hondeghem LM. Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes. Circulation 1995: 92: 3014-3024.
6. Cox CR, Faccenda KA, Gilhooly C, Bannister J, Scott NB, Morrison LMM. Extradural S(-)-bupivacaine: Comparison with racemic RS-bupivacaine. Br J Anaesth 1998: 80: 289-293.
7. Lyons G, Columb M, Wilson RC, Johnson RV. Epidural pain relief in labour: Potencies of levobupivacaine and racemic bupivacaine. Br J Anaesth 1998: 81: 899-901.
8. Reiz S, Haggmark S, Johannson G, Nath S. Cardiotoxicity of ropivacaine: A new amide local anaesthetic agent. Acta Anaesthesiol Scand 1989: 33: 93-98.
9. Scott DB, Lee A, Pagan D, Bowler GMR, Bloomfield P, Lundh R. Acute toxicity of ropivacaine compared with that of bupivacaine. Anesth Analg 1989: 69: 563-569.
10. Åkerman B, Hellberg IB, Trossvil C. Primary evaluation of the local anaesthetic properties of the amino amide agent ropivacaine (LEA 103). Acta Anaesthesiol Scand 1988: 32: 571-578.
11. Brown DL, Carpenter RL, Thompson GE. Comparison of 0.5% ropivacaine and 0.5% bupivacaine for epidural anesthesia in patients undergoing lower-extremity surgery. Anesthesiology 1990: 72: 633-636.
12. Morrison LMM, Emanuelson BM, McCrure JH, McClure JH, McKeown D, Brockway MS, Jozwiak H, Wildsmith JAW. Efficacy and kinetics of extradural ropivacaine: Comparison with bupivacaine. Br J Anaesth 1994: 72: 164-169.
13. Griffin RP, Reynolds E Extradural anaesthesia for Caesarean section: A double blind comparison of 0.5% ropivacaine with 0.5% bupivacaine. Br J Anaesth 1995: 74: 512-516.
14. Van Kleef JW, Veering BT, Burm AG. Spinal anesthesia with ropivacaine: A double-blind study on the efficacy and safety of 0.5% and 0.75% solutions in patients undergoing minor lower limb surgery. Anesth Analg 1994: 78: 1125-1130.
15. Dyhre H, Lång M, Wallin R, Renck H. The duration of action of bupivacaine, levobupivacaine, ropivacaine and pethidine in peripheral nerve block in the rat. Acta Anaesthesiol Scand 1997: 41: 1346-1352.
16. Popitz-Bergez FA, Leeson S, Strichartz GR, Thalhammer JG. Relation between functional deficit and intraneural local anesthetic during peripheral nerve block. Anesthesiology 1995: 83: 583-592.
17. Hylden JL, Wilcox GL. Intrathecal morphine in mice: A new technique. Eur J Pharmacol 1980: 67: 313-316.
18. Feldman HS, Dvoskin S, Halldin MH, Ask A-L, Doucette AM. Comparative local anesthetic efficacy and pharmacokinetics of epidurally administered ropivacaine and bupivacaine in the sheep. Reg Anesth 1997: 22: 451-460.
19. Strichartz GR, Sanchez V, Arthur GR, Chafetz R, Martin D. Fundamental properties of local anesthetics. II. Measured octanol:buffer partition coefficients and pKa values of clinically used drugs. Anesth Analg 1990: 71: 158-170.
20. Arthur GR, Feldman HS, Covino BG. Comparative pharmacokinetics of bupivacaine and ropivacaine, a new amide local anesthetic. Anesth Analg 1988: 67: 1053-1058.
21. Feldman HS, Covino BG. Comparative motor-blocking effects of bupivacaine and ropivacaine, a new amino amide local anesthetic, in the rat and dog. Anesth Analg 1988: 67: 1047-1052.
22. Kopacz DJ, Alien HW, Thompson GE, Gennery B, Watkins K, Stephenson C, Klakken S, Krider J. Doubleblind randomized trial of 0.75% levobupivacaine compared to 0.75% bupivacaine for epidural anesthesia in patients undergoing major elective abdominal surgery [abstract]. Anesth Analg 1998: 86: S281.
23. McClellan KJ, Spencer CM. Levobupivacaine. Drugs 1998: 56: 355-364.
24. Luduena FP, Bogado EF, Tullar BF. Optical isomers of mepivacaine and bupivacaine. Arch Int Pharmacodyn 1972: 200: 359-369.
25. Brockway MS, Bannister J, McClure JH, McKeown D, Wildsmith JAW. Comparison of extradural ropivacaine and bupivacaine. Br J Anaesth 1991: 6: 31-37.
26. Kristensen JD, Karlsten R, Gordh T. Spinal cord blood flow after intrathecal injection of ropivacaine and bupivacaine with or without epinephrine in rats. Acta Anaesthesiol Scand 1998: 42: 685-690.
27. Levin A, Datta S, Camann WR. Intrathecal ropivacaine for labor analgesia: A comparison with bupivacaine. Anesth Analg 1998: 87: 624-627.
28. Bromage PR. Lower limb reflex changes in segmental epidural analgesia. Br J Anaesth 1974: 46: 504-508.
29. Scott DB, McClure JH, Giasi RM, Seo J, Covino BG. Effects of concentration of local anaesthetic drugs in extradural block. Br J Anaesth 1980: 52: 1033-1077.
30. Bader AM, Datta S, Flanagan H, Covino BG. Comparison of bupivacaine- and ropivacaine-induced conduction blockade in the isolated rabbit vagus nerve. Anesth Analg 1989: 68: 724-727.