Amrinone prevents the inhibition of muscle pyruvate dehydrogenase complex activity during sepsis

Shock

Volumn 5, Issue 3, 1996, Pages 229-232

  Vary, Thomas C ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMRINONE; ENZYME INHIBITOR; LACTIC ACID; LACTIC ACID DERIVATIVE; PYRUVATE DEHYDROGENASE COMPLEX;

ANIMAL; ARTICLE; BLOOD; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; MALE; RAT; REGRESSION ANALYSIS; SEPSIS; SKELETAL MUSCLE; SPRAGUE DAWLEY RAT; STATISTICAL MODEL;

AMRINONE; ANIMALS; ENZYME INHIBITORS; LACTATES; LACTIC ACID; LEAST-SQUARES ANALYSIS; LINEAR MODELS; MALE; MUSCLE, SKELETAL; PYRUVATE DEHYDROGENASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS;

EID: 0030103428     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-199603000-00011     Document Type: Article

References (27)

1. Cerra FB: Hypermetabolism-organ failure syndrome: A metabolic response to injury. Crit Care Clin 5:289-301, 1989.
2. Vary TC, Siegel JH: Sepsis, abnormal metabolic control and the multiple organ failure syndrome. In Siegel JH (ed) Trauma: Emergency Surgery and Critical Care. New York: Churchill Livingstone, 1987, pp 411-502.
3. Vary TC, Siegel JH, Rivikind A: Clinical and therapeutic significance of metabolic patterns of lactic acidosis. Perspect Crit Care 1:85-132, 1988.
4. Siegel JH, Rivikind AI, Dalal S, Goodari S: Early physiologic predictors of injury and death in blunt multiple trauma. Arch Surg 125:498-508, 1990.
5. Cerra FB: Metabolic manifestations of multiple organ failure. Crit Care Clin 5:119-131, 1989.
6. Lang CH, Dobrescu C: In vivo insulin resistance during nonlethal hypermetabolic sepsis. Circ Shock 28:165-178, 1989.
7. Lang CH, Dobrescu C: Gram-negative infection increases non-insulin-mediated glucose dispersal. Endocrinology 128:645-653, 1991.
8. Meszaros K, Bagby GJ, Lang CH, Spitzer JJ: Increased uptake and phosphorylation of 2-deoxyglucose by skeletal muscle in endotoxin-treated rats. Am J Physiol 253(Endrocrinology Metab 16):E33-E39, 1987.
9. Vary TC, Drnevich D, Jurasinski C, Brennan WA: Mechanisms regulating skeletal muscle glucose metabolism in sepsis. Shock 3:403-410, 1995.
10. Vary TC, Siegel JH, Nakatani T, Sato T, Aoyama H: Effect of sepsis on the activity of the pyruvate dehydrogenase complex in skeletal muscle and liver. Am J Physiol 250(Endocrinol Metab 16):E634-E640, 1986.
11. Vary TC, Siegel JH, Tall BD, Morris JG: Altered glucose regulation in sepsis revealed by partial reversal of PDH inhibition by dichloroacetate. Circ Shock 24:3-18, 1988.
12. Vary TC, Murphy JM: Role of extra-splanchnic organs in the metabolic response to sepsis: Effect of insulin. Circ Shock 29:41-57, 1989.
13. Vary, TC: Increased pyruvate dehydrogenase kinase activity in response to sepsis. Am J Physiol 260(Endocrinol Metab 23):E669-E674, 1991.
14. Cerra FB, West M, Keller G, Mzuski J, Simmons RL: Hypermetabolism/ organ failure: Role of activated macrophage as a metabolic regulator. Prog Clin Biol Med 264:27-42, 1988.
15. Tracey KA: Tumor necrosis factor/cachetin in biology of the septic shock syndrome. Circ Shock 35:123-128, 1991.
16. Blackham B, Cesar D, Park O-J, et al: Effects of recombinant monokines on hepatic pyruvate dehydrogenase, pyruvate dehydrogenase kinase, do novo lipogenesis and plasma triglycerides: Abolition by prior fasting. Biochem J 284:129-135, 1992.
17. Jurasinski CV, Kilpatrick L, Vary TC: Amrinone prevents muscle wasting during chronic sepsis. Am J Physiol 268(Endocrinol Metab 31):E491-E500, 1995.
18. Martin LF, Vary TC, Davis PK, et al: Intravascular plastic catheters potentiate tumor necrosis factor (TNF) release and exacerbates complications associated with surgery. Arch Surg 126:1087-1093, 1991.
19. Cooney RN, Owens E, Jurasinski C, Gray K, Vannice J, Vary T: Interleukin-1 receptor antagonist prevents sepsis-induced inhibition of protein synthesis. Am J Physiol 261(Endocrinol Metab 30):E636-E641, 1994.
20. Coore HG, Denton RM, Martin BR, Randle PJ: Regulation of adipose tissue pyruvate dehydrogenase by insulin and other hormones. Biochem J 125:115-127, 1971.
21. Vary TC, Siegel JH, Placko R, Tall BD, Morris JG: Effect of dichloro-acetate on plasma and hepatic amino acids in sterile inflammation and sepsis. Arch Surg 124:1071-1077, 1989.
22. Doherty GM, Jensen JC, Alexander HR, Buresh CM, Norton JA: Pentoxifylline suppression of tumor necrosis factor gene transcription. Surgery 111:192-198, 1991.
23. Giroir BP, Beutler B: Effect of amrinone on tumor necrosis factor production in endotoxin shock. Circ Shock 36:200-207, 1992.
24. Breuille DM, Farge MC, Rose R, Arnal M, Obled C: Pentoxyfylline decreases the body weight loss and muscle protein wasting characteristic of sepsis. Am J Physiol 265(Endocrinol Metabol 28):E660-E666, 1993.
25. Vary TC, Plack R, Siegel JH: Pharmacologic modulation of increased release of gluconoegenic precursors from extra-splanchnic organs. Circ Shock 29:59-76, 1989.
26. Petit F, Bagby GJ, Lang CH: Tumor necrosis factor mediates zymogen-induced increase in glucose flux and insulin resistance. Am J Physiol 268(Endocrinol Metabol 31):E219-E228, 1995.
27. Bagby GJ, Lang CH, Skrepnik N, Golightly G, Spitzer JJ: Regulation of glucose metabolism after endotoxin and during infection is largely independent of endogenous tumor necrosis factor. Circ Shock 39:211-219, 1993.