Effects of intravenously administered yohimbine on antinociceptive, cardiorespiratory, and postural changes induced by epidural administration of detomidine hydrochloride solution to healthy mares

American Journal of Veterinary Research

Volumn 60, Issue 10, 1999, Pages 1262-1270

  Skarda, Roman T ^a   Muir III, William W ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DETOMIDINE; YOHIMBINE;

ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; BREATHING RATE; CONTROLLED STUDY; DIURESIS; DRUG ANTAGONISM; DRUG EFFECT; EPIDURAL DRUG ADMINISTRATION; FEMALE; HEART OUTPUT; HEART RATE; HORSE; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; RANDOMIZATION; RESPIRATION DEPRESSION; SWEATING;

ADRENERGIC ALPHA-ANTAGONISTS; ANALGESIA; ANALGESICS; ANIMALS; CARBON DIOXIDE; CARDIAC OUTPUT; CROSS-OVER STUDIES; DIURESIS; ELECTRIC STIMULATION; FEMALE; HEART RATE; HEMODYNAMIC PROCESSES; HORSES; IMIDAZOLES; INJECTIONS, EPIDURAL; INJECTIONS, INTRAVENOUS; OXYGEN; PAIN; POSTURE; RESPIRATORY MECHANICS; SWEATING; YOHIMBINE;

EID: 0032846634     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (71)

1. Grubb TL, Riebold TW, Huber MJ. Comparison of lidocaine, xylazine, and xylazine/lidocaine for caudal epidural analgesia in horses. J Am Vet Med Assoc 1992;201:1187-1190.
2. Skarda RT, Muir WW. Continuous caudal epidural and subarachnoid anesthesia in mares: a comparative study. Am J Vet Res 1983;44:2290-2298.
3. LeBlanc PH, CaronJP, Patterson JS, et al. Epidural injection of xylazine for perineal analgesia in horses. J Am Vet Med Assoc 1988;193:1405-1408.
4. Skarda RT, Muir WW III. Analgesic, hemodynamic, and respiratory effects of caudal epidurally administered xylazine hydrochloride solution in mares. Am J Vet Res 1996;57:193-200.
5. Skarda RT, Muir WW III. Comparison of antinociceptive, cardiovascular, and respiratory effects, head ptosis, and position of pelvic limbs in mares after epidural administration of xylazine and detomidine hydrochloride solution. Am J Vet Res 1996;57:1338-1345.
6. Skarda RT, Muir WW III. Caudal analgesia induced by epidural or subarachnoid administration of detomidine hydrochloride solution in mares. Am J Vet Res 1994;55:670-680.
7. Skarda RT, Muir WW III. Influence of atipamezole on effects of midsacral subarachnoidally administered detomidine in mares. Am J Vet Res 1998;59:468-477.
8. 2-adrenoreceptor. J Pharmacol Exp Ther 1983;35:143-180.
9. 2-Adrenoceptors mediate clonidine-induced sedation in the rat. Br J Pharmacol 1979;67: 133-141.
10. Ortmann R, Mutter M, Delini-Stula A. Effect of yohimbine and its diastereoisomers on clonidine-induced depression of exploration in the rat. Eur J Pharmacol 1982;77:335-337.
11. 2-adrenoceptors participating in the central hypotensive and sedative effects of clonidine using yohimbine, rauwolscine and corynanthine. Eur J Pharmacol 1981;70:7-15.
12. Strömbom U. On the functional role of pre- and postsynaptic catecholamine receptors in the brain. Acta Physiol Scand Suppl 1975;431:1-43.
13. Anden NE, Grabowska M, Strömbom U. Different alpha-adrenoceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor binding agents. Naunyn Schmiedeberg's Arch Pharmacol 1976;292:43-52.
14. Putkonen PTS, Leppävuori A, Sternberg D. Paradoxical sleep inhibition by central alpha-adrenoceptor stimulant clonidine antagonized by alpha-receptor blocker yohimbine. Life Sci 1977;21:1059-1066.
15. 2-adrenoceptors participating in the central hypotensive and sedative effects of clonidine, using yohimbine, rauwolscine and corynanthine. Eur J Pharmacol 1981;70:7-15.
16. Leppävuori A. The effects of an alpha-adrenergic agonist or antagonist on sleep during blockade of catecholamine synthesis in the cat. Brain Res 1980;193:117-128.
17. Hsu WH. Xylazine-induced depression and its antagonism by alpha blocking drugs. J Pharmacol Exp Ther 1981;218:188-192.
18. Papeschi R, Sourkes TL, Youdim MBH. The effect of yohimbine on brain serotonin metabolism motor behavior and body temperature of the rat. Eur J Pharmacol 1971;15:318-326.
19. Tayo FM. Prejunctional inhibitatory α-adrenoceptors and dopaminoceptors in the rat deferens and the guinea pig ileum. Eur J Pharmacol 1979;58:189-195.
20. Kollias-Baker CA, Court MH, Williams LL. Influence of yohimbine and tolazoline on the cardiovascular, respiratory, and sedative effects of xylazine in the horse. J Vet Pharmacol Therap 1993;16:350-358.
21. Green SA, Thurmon JC, Tranquilli WJ, et al. Effect of yohimbine on xylazine-induced hypoinsulinemia and hyperglycemia in mares. Am J Vet Res 1987;48:676-678.
22. Grubb TL, Muir WW III, Bertone AL, et al. Use of yohimbine to reverse prolonged effects of xylazine hydrochloride in a horse being treated with chloramphenicol. J Am Vet Med Assoc 1997;210: 1771-1773.
23. Kitzman JV, Wilson RC, Hatch RC, et al. Antagonism of xylazine and ketamine anesthesia by 4-aminopyridine and yohimbine in geldings. Am J Vet Res 1984;45:875-879.
24. McGruder JP, Hsu WH. Antagonism of xylazine-pentobarbital anesthesia by yohimbine in ponies. Am J Vet Res 1985;46: 1276-1281.
25. Salonen JS, Vähä-Vahe T, Vainio O, et al. Single-dose pharmacokinetics of detomidine in the horse and cow. J Vet Pharmacol Therap 1989;12:65-72.
26. Jernigan AD, Wilson RC, Booth NH, et al. Comparative pharmacokinetics of yohimbine in steers, horses and dogs. Can J Vet Res 1988;52:172-176.
27. 2-adrenoceptors participating in the central hypotensive and sedative effects of clonidine using yohimbine, rauwolscine and corynanthine. Eur J Pharmacol 1981;70:7-15.
28. Kamerling SG, Cravens WT, Bagwell CA. Dose-related effects of detomidine on autonomic responses in the horse. J Auton Pharmacol 1988;8:241-249.
29. Kamerling SG, Cravens WT, Bagwell CA. Objective assessment of detomidine-induced analgesia and sedation in the horse. Eur J Pharmacol 1988;151:1-8.
30. 2 receptor agonist dexmedetomidine in dogs. Anesthesiology 1994;80:1057-1072.
31. Stamford JA. Descending control of pain. Br J Anaesth 1995;75:217-227.
32. Maze M, Tranquilli W. Alpha-2 adrenoceptor agonists: defining the role in clinical anesthesia. Anesthesiology 1991;74: 581-605.
33. Loomis CW, Jhamandas K, Milne B, et al. Monoamine and opioid interactions in spinal analgesia and tolerance. Pharmacol Biochem Behav 1987;26:445-451.
34. Osipov HM, Suarez LJ, Spoulding TC. Antinociceptive interactions between alpha-2 adrenergic and opiate agonists at the spinal level in rodents. Anesth Analg 1989;68:194-200.
35. Duan J, Sawynok J. Enhancement of clonidine-induced analgesia by lesions with spinal and intracerebroventricular administration of 5,7-dihydrotryptamine. Neuropharmacology 1987;26:323-329.
36. Sweeney MI, White TD, Sawynok J. Involvement of adenosine in the spinal antinociceptive effects of morphine and noradrenaline. J Pharmacol Exp Ther 1987;243:657-665
37. Yaksh TL. Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing. Pharmacol Biochem Behav 1985;22:845-858.
38. Kuraishi Y, Hirota N, Suto Y, et al. Noradrenergic inhibition of release of substance P from the primary afferents in the rabbit spinal dorsal horn. Brain Res 1985;359:177-182.
39. Howe JR, Wang Jia-Yi, Yaksh TL. Selective antagonism of the antinociceptive effect of intrathecally applied alpha adrenergic agonists by intrathecal prazosin and intrathecal yohimbine. J Pharmacol Exp Ther 1983;224:552-558.
40. Komulainen A, Olson ME. Antagonism of ketamine-xylazine anesthesia in rats by administration of yohimbine, tolazoline, or 4-ammopyridine. Am J Vet Res 1991;52:585-588.
41. Wallner BM, Hatch RC, Booth NH, et al. Complete immobility produced in dogs by xylazine-atropine: antagonism by 4-aminopyridine and yohimbine. Am J Vet Res 1982;43:2259-2265.
42. Hsu WH, Lu Z-X, Hembrough FB. Effect of xylazine on heart rate and arterial blood pressure in conscious dogs, as influenced by atropine, 4-aminopyridine, doxapram, and yohimbine. J Am Vet Med Assoc 1985;186:153-156.
43. Hsu WH, Lu Z-X, Hembrough FB. Effect of amitraz on heart rate and aortic blood pressure in conscious dogs: influence of atropine, prazosin, tolazoline, and yohimbine. Tox Appl Pharmacol 1986;84:418-422.
44. Hsu WH, Rong Y-F, Hembrough FB. The effects of jingsongling, a xylazine analog, on mean arterial blood pressure and heart rate in dogs - influences of yohimbine, tolazoline, prazosin, and atropine. J Vet Pharmacol Therap 1989;12:283-288.
45. Hatch RC, Kitzman JV, Zahner JM. Antagonism of xylazine sedation with yohimbine, 4-ammopyridine, and doxapram in dogs. Am J Vet Res 1985;46:371-375.
46. Hatch RC, Booth NH, Clark JD, et al. Antagonism of xylazine sedation in dogs by 4-aminopyridine and yohimbine. Am J Vet Res 1982; 44:1009-1014.
47. Hatch RC, Booth NH, Kitzman JV, et al. Antagonism of ketamine anesthesia in cats by 4-aminopyridine and yohimbine. Am J Vet Res 1982;44:417-423.
48. Kitzman JV, Booth NH, Hatch RC, et al. Antagonism of xylazine sedation by 4-aminopyridine and yohimbine in cattle. Am J Vet Res 1982;43:2165-2169.
49. Hikasa Y, Takase K, Emi S, et al. Antagonistic effects of alpha-adrenoceptor blocking agents on reticuloruminal hypomotility induced by xylazine in cattle. Can J Vet Res 1988;52:411-415.
50. Ko JCH, McGrath CJ. Effects of atipamezole and yohimbine on medetomidine-induced central nervous system depression and cardiorespiratory changes in lambs. Am J Vet Res 1995;56:629-632.
51. Hsu WH, Schaffer DD, Hanson CE. Effects of tolazoline and yohimbine on xylazine-induced central nervous system depression, bradycardia, and tachypnea in sheep. J Am Vet Med Assoc 1987;190: 423-426.
52. Hsu WH, Hanson CE, Hembrough FB, et al. Effects of idazoxan, tolazoline, and yohimbine on xylazine-induced respiratory changes and central nervous system depression in ewes. Am J Vet Res 1989;50:1570-1573.
53. Riebold TW, Kaneps AJ, Schmotzer WB. Reversal of xylazine-induced sedation in llamas, using doxapram or 4-aminopyridine and yohimbine. J Am Vet Med Assoc 1986;189:1059-1061.
54. Hsu WH, Shulaw WP Effect of yohimbine on xylazine induced immobilization in white-tailed deer. J Am Vet Med Assoc 1984;185:1301-1303.
55. Jessup DA, Jones K, Mohr R, et al. Yohimbine antagonism to xylazine in free-ranging mule deer and desert bighorn sheep. J Am Vet Med Assoc 1985;187:1251-1253.
56. Savola J-M. Cardiovascular actions of detomidine. Acta Vet Scand Suppl 1986;82:47-57.
57. Wagner AE, Muir WW III, Hinchcliff KW. Cardiovascular effects of xylazine and detomidine in horses. Am J Vet Res 1991; 52:651-657.
58. Ramseyer B, Schmucker N, Schatzmann U, et al. Antagonism of detomidine sedation with atipamezole in horses. J Vet Anaesth 1998;25:47-51.
59. 2-adrenoceptors by atipamezole. Arch Int Pharmacol Ther 1989;297:190-204.
60. Virtanen R. Pharmacological profiles of medetomidine and its antagonist, atipamezole. Acta Vet Scand Suppl 1989;85:29-37.
61. Raekallio M, Vainio O, KarjalainenJ. The influence of detomidine and epinephrine on heart rate, arterial blood pressure, and cardiac arrhythmia in horses Vet Surg 1991;20:468-473.
62. Van Zwieten PA, Thoolen MJMC, Timmermans PBMWM. The pharmacology of centrally acting hypertensive drugs. Br J Clin Pharmacol 1983;15(suppl):455-462.
63. Van Zwieten PA. Antihypertensive drugs with a central action. Prog Pharmacol 1975;1:1-63.
64. Robinson NE. The respiratory system. In Muir WW, Hubbell JAE, eds. Equine anesthesia monitoring and emergency therapy. St Louis, Mo: Mosby Year Book Inc, 1991;8.
65. Mueller RA, Lundberg DBA, Breese GR, et al. The neuropharmacology of respiratory control. Pharmacol Rev 1982;34:255-285.
66. Kamerling S, Nauman S, Keowen M, et al. Antagonism of the effects of detomidine by atipamezole. Acta Vet Scand Suppl 1991;87:163-165.
67. Raekallio M, Vainio O, Karjalainen J. The influence of atipamezole on the cardiovascular effects of detomidine in horses. J Assoc Vet Anaesth Great Britain and Ireland 1990;17:50-53.
68. Gasthuys F, Terpstra P, Van den Hende C, et al. Hyperglycaemia and diuresis during sedation with detomidine in the horse. Zentralbl Veterinarmed [A] 1987;34:641-648.
69. 2-adrenoceptors. Am J Physiol 1990;259:F1-F8.
70. Carroll GL, Matthews NS, Hartsfield SM, et al. The effect of detomidine and its antagonism with tolazoline on stress-related hormones, metabolites, physiologic responses, and behavior in awake ponies. Vet Surg 1997;26:69-77.
71. 2-adrenoceptor agonist atipamezole. Anesthesiology 1998;89:574-584.