Ozone-induced hyperresponsiveness and blockade of M2 muscarinic receptors by eosinophil major basic protein

Journal of Applied Physiology

Volumn 87, Issue 4, 1999, Pages 1272-1278

  Yost, Bethany L ^a   Gleich, Gerald J ^b   Fryer, Allison D ^a  

^a The Johns Hopkins University   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Asthma; Hyperreactivity; Inflammation; Neuronal receptors

Indexed keywords

ACETYLCHOLINE; HEPARIN; INTERLEUKIN 5; MAJOR BASIC PROTEIN; MUSCARINIC M2 RECEPTOR; OZONE; PILOCARPINE;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; EOSINOPHIL; IMMUNOSTIMULATION; NONHUMAN; PARASYMPATHETIC NERVE; PRIORITY JOURNAL; RECEPTOR BLOCKING;

EID: 0032845711     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1999.87.4.1272     Document Type: Article

References (38)

1. Ayala, L. E., and T. Ahmed. Is there loss of a protective muscarinic receptor in asthma? Chest 96: 1285-1291, 1989.
2. Baker, D. G. and J. K. Brown. Potent muscarinic cholinergic regulation of acetylcholine release from nerve endings in airway smooth muscle (Abstract). Am. Rev. Respir. Dis. 143: A358, 1991.
3. 2 muscarinic receptor dysfunction. J. Appl. Physiol. 85: 1708-1718, 1998.
4. Blaber, L. C., A. D. Fryer, and J. Maclagan. Neuronal muscarinic receptors attenuate vagally-induced contraction of feline bronchial smooth muscle. Br. J. Pharmacol. 86: 723-728, 1985.
5. Costello, R. W., and A. D. Fryer. Cholinergic mechanisms in asthma. In: Asthma, edited by P. J. Barnes, M. M. Grunstein, A. Leff, and A. Woolcock. Philadelphia, PA: Lippincott-Raven, 1997, p. 965-984.
6. Dixon, W. E., and T. G. Brody. Contributions to the physiology of the lungs. Part 1. The bronchial muscles and their innervation and the action of drugs upon them. J. Physiol. (Lond.) 29: 97-173, 1903.
7. 2 muscarinic receptor function in antigen challenged guinea pigs. Am. J. Respir. Cell Mol. Biol. 12: 320-328, 1995.
8. 2 receptor function in antigen challenged guinea pigs in vivo. J. Clin. Invest. 100: 2254-2262, 1997.
9. 2 muscarinic receptors in antigen challenged guinea pig airways. J. Clin. Invest. 99: 2036-2044, 1997.
10. 2 muscarinic receptors in antigen challenged guinea-pigs is restored by heparin and poly-L-glutamate. J. Clin. Invest. 90: 2292-2298, 1992.
11. 2 muscarinic receptors on pulmonary parasympathetic nerves in the guinea-pig. Br. J. Pharmacol. 102: 267-271, 1991.
12. Fryer, A. D., and J. Maclagan. Muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea-pig. Br. J. Pharmacol. 83: 973-978, 1984.
13. 2 muscarinic receptors in pulmonary parasympathetic nerves after antigen challenge in guinea pigs. J. Appl. Physiol. 71: 2255-2261, 1991.
14. 2 muscarinic receptor function in parainfluenza virus-infected guinea-pigs. Br. J. Pharmacol. 112: 588-594, 1994.
15. 2 muscarinic receptor function is prevented by cyclophosphamide. J. Appl. Physiol. 77: 1492-1499, 1994.
16. Gleich, G. J., D. A. Loegering, and J. E. Maldonado. Identification of a major basic protein in guinea pig eosinophil granules. J. Exp. Med. 137: 1459-1471, 1973.
17. Gordon, T., C. S. Venugopalan, M. O. Amdur, and J. M. Drazen. Ozone-induced airway hyperreactivity in the guinea pig. J. Appl. Physiol. 57: 1034-1038, 1984.
18. Green, C. J. Animal Anaesthesia. London: Laboratory Animals, 1979, p. 81-82. (Laboratory Animal Handbook no. 8)
19. Holtzman, M. J., L. M. Fabbri, P. M. O'Byrne, B. D. Gold, H. Aizawa, E. H. Walters, S. E. Alpert, and J. A. Nadel. Importance of airway inflammation for hyperresponsiveness induced by ozone in dogs. Am. Rev. Respir Dis. 127: 686-690, 1983.
20. Holtzman, M. J., L. M. Fabbri, B. E. Skoogh, P. M. O'Byrne, E. H. Walters, H. Aizawa, and J. A. Nadel. Time course of airway hyperresponsiveness induced by ozone in dogs. J. Appl. Physiol. 55: 1232-1236, 1983.
21. Jacoby, D., G. Gleich, and A. Fryer. Interaction of human eosinophil major basic protein with cloned human muscarinic receptors (Abstract). Am. J. Respir. Crit. Care Med. 151: A821, 1995.
22. 2 receptor. J. Clin. Invest. 91: 1314-1318, 1993.
23. Kubo, T., K. Sukuda, A. Mikami, A. Maeda, H. Takahashi, M. Mishina, T. Haga, K. Haga, A. Ichiyama, K. Kangawa, M. Kojima, H. Matsuo, T. Hirose, and S. Numa. Cloning, sequencing, and expression of complementary DNA encoding the muscarinic acetylcholine receptor. Nature 323: 411-416, 1988.
24. Langley, J. N. On the physiology of salivary secretion. J. Physiol. (Lond.) 1: 339-369, 1878.
25. Lee, L. Y., E. R. Bleeker, and J. A. Nadel. Effect of ozone on bronchomotor response to inhaled histamine aerosol in dogs. J. Appl. Physiol. 43: 626-631, 1977.
26. Lewis, D. M., D. A. Loegering, and G. J. Gleich. Antiserum to the major basic protein of guinea pig eosinophil granules. Immunochemistry 13: 743-746, 1976.
27. Mauser, P. J., A. Pitman, A. Witt, X. Fernandez, J. Zurcher, T. Kung, H. Jones, A. S. Watnick, R. W. Egan, W. Kreutner, and G. K. Adams. Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma. Am. Rev. Respir. Dis. 148: 1623-1627, 1993.
28. Mauser, P. J., A. M. Pitman, X. Fernandez, S. K. Foran, G. K. Adams, W. Kreutner, R. W. Egan, and R. W. Chapman. Effects of an antibody to interleukin-5 in a monkey model of asthma. Am. J. Respir. Crit. Care Med. 152: 467-472, 1995.
29. Minette, P., and P. J. Barnes. Prejunctional inhibitory muscarinic receptors on cholinergic nerves in human and guinea pig airways. J. Appl. Physiol. 64: 2532-2537, 1988.
30. Minette, P. J., J. W. J. Lammers, C. M. S. Dixon, M. T. McCusker, and P. J. Barnes. A muscarinic agonist inhibits reflex bronchoconstriction in normal but not asthmatic subjects. J. Appl. Physiol. 67: 2461-2465, 1989.
31. Nadel, J., and P. Barnes. Autonomic regulation of the airways. Annu. Rev. Med. 35: 451-467, 1984.
32. O'Byrne, P., E. Walters, B. Gold, H. Aizawa, L. Fabbri, S. Alpert, J. Nadel, and M. Holtzman. Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposure. Am. Rev. Respir. Dis. 130: 214-219, 1984.
33. 2 receptors in bovine tracheal smooth muscle: discrepancies between binding and function. Eur. J. Pharmacol. 153: 73-82, 1988.
34. 3 receptors mediate contraction of human central and peripheral airway smooth muscle. Pulm. Pharmacol. 3: 47-51, 1990.
35. Roffel, A. F., H. Meurs, C. R. S. Elzinga, and J. Zaagsma. Characterization of the muscarinic receptor subtype involved in phosphoinositide metabolism in bovine tracheal smooth muscle. Br. J. Pharmacol. 99: 293-296, 1990.
36. 2 muscarinic receptor function. J. Appl. Physiol. 76: 1088-1097, 1994.
37. Walters, E. H., P. M. O'Byrne, P. D. Graf, L. M. Fabbri, and J. A. Nadel. The responsiveness of airway smooth muscle in vitro from dogs with airway hyperresponsiveness in vivo. Clin. Sci. (Colch.) 71: 605-611, 1986.
38. Warr, G. A., and G. J. Jakab. Pulmonary inflammatory responses during viral pneumonia and secondary bacterial infection. Inflammation 7: 93-104, 1983.