Differential effects of lithium on platelet protein phosphorylation in bipolar patients and healthy subjects

Psychopharmacology

Volumn 129, Issue 1, 1997, Pages 44-47

  Zanardi, Raffaella ^a   Racagni, Giorgio ^a   Smeraldi, Enrico ^a   Perez, Jorge ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

bipolar disorder; lithium; platelet; protein phosphorylation

Indexed keywords

CYCLIC AMP; LITHIUM; PHOSPHOPROTEIN; PHOSPHORUS 32;

ADULT; ARTICLE; BIPOLAR DEPRESSION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN EXPERIMENT; MALE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; THROMBOCYTE; VOLUNTEER;

ADULT; ANTIMANIC AGENTS; BIPOLAR DISORDER; BLOOD PLATELETS; CYCLIC AMP; HUMANS; LITHIUM; MALE; PHOSPHORUS RADIOISOTOPES; PHOSPHORYLATION;

EID: 0031022814     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050160     Document Type: Article

References (23)

1. American Psychiatry Association (1994) Diagnostic and statistical manual of mental disorders. 4th edn (DSM-IV). American Psychiatry Association. Washington. DC
2. + in the treatment of bipolar disorder. Trends Neurosci 18:343-349
3. Bradford MM (1976) Rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 72:248-254
4. 1-protein α subunit in rat cerebral cortex. Proc Natl Acad Sci USA 88:10634-10637
5. Dubovsky SL, Christiano J, Daniell LC, Franks RD, Murphy J. Adler L, Baker N, Harris A (1989) Increased platelet intracellular calcium concentration in patients with bipolar affective disorders. Arch Gen Psychiatry 46:632-638
6. Friedman E, Wang HY, Levinson D, Connell TA. Singh H (1993) Altered platelet protein kinase C activity in bipolar affective disorder, manic episode. Biol Psychiatry 33:520-525
7. Guitart X, Nestler EJ (1992) Chronic administration of lithium or other antidepressants increases levels of DARPP-32 in rat frontal cortex. J Neurochem 59:1164-1167
8. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56-62
9. Heuser IJE, Schweiger U, Gotthardt U, Schmider J, Lammers C, Dettling M, Yassouridis A, Holsboer F (1996) Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects. Am J Psychiatry 153:93-99
10. Jope RS, Williams MB (1994) Lithium and brain signal transduction system. Biochem Pharmacol 47:429-441
11. Kikuchi A, Yamashita T, Kawata M, Ikeda K, Tanimoto T, Takai Y (1988) Purification and characterization of a novel-GTP-binding protein with a molecular weight of 24,000 from bovine brain membrane. J Biol Chem 263:2897-2904
12. Kim S, Mizoguchi A, Kikuchi A. Takai Y (1990) Tissue and sub-cellular distributions of the smg-21/rap1/Krev-1 proteins which are partly distinct from those of c-ras p21s. Mol Cell Biol 10:2645-2652
13. Lenox RH, Watson DG, Patel J, Ellis J (1992) Chronic lithium administration alters a prominent PKC substrate in rat hippocampus. Brain Res 570:333-340
14. Manji HK, Potter WZ, Lenox RH (1995a) Signal transduction pathways. Molecular targets for lithium's action. Arch Gen Psychiatry 52:531-543
15. Manji HK, Chen G, Shimon H, Hsiao JK, Potter WZ, Belmaker RH (1995b) Guanine nucleotide-binding proteins in bipolar affective disorder. Arch Gen Psychiatry 52: 135-144
16. Nagata K, Itoh H, Katada T, Takenaka K, Ui M, Kaziro Y, Nozawa Y (1989) Purification, identification and characterization of two GTP-binding proteins with molecular weights of 25,000 and 21,000 in human platelet cytosol. J Biol Chem 264:17000-17005
17. Perez J, Zanardi R, Mori S, Gasperini M, Smeraldi E, Racagni G (1995) Abnormalities of cAMP-dependent endogenous phosphorylation in platelets from patients with bipolar disorder. Am J Psychiatry 152: 1204-1206
18. Price LH, Heninger GR (1994) Lithium in the treatment of mood disorders. N Engl J Med 331:591-598
19. Risby ED, Hsiao JK, Manji HK, Bitran J, Moses F, Zhou DF, Potter WZ (1991) The mechanism of action of lithium. Effects on adenylate cyclase activity and β-adrenergic receptor binding in normal subjects. Arch Gen Psychiatry 48:513-524
20. Schreiber G, Avissar S, Danon A, Belmaker RH (1991) Hyperfunctional G proteins in mononuclear leukocytes of patients with mania. Biol Psychiatry 29:273-280
21. Young RC, Biggs JT, Ziegler VE, Meyer DA (1978) A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 133:429-435
22. xα protein levels and forskolin-stimulated cAMP formation are increased in bipolar affective disorders. J Neurochem 61:890-898
23. Young LT, Li PP, Kamble A, Siu KP, Warsh JJ (1994) Mononuelear leukocyte levels of G proteins in depressed patients with bipolar disorder or major depressive disorder. Am J Psychiatry 151:594-596