The maximum pharmacodynamic effect as a response parameter: Pharmacokinetic considerations

Journal of Pharmacy and Pharmacology

Volumn 51, Issue 9, 1999, Pages 999-1008

  Leopold, Claudia S ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; COMPARTMENT MODEL; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG CONCENTRATION; DRUG ELIMINATION; DRUG PENETRATION; PHARMACODYNAMICS; SIMULATION; THERMODYNAMICS;

ADMINISTRATION, TOPICAL; BIOLOGICAL AVAILABILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, THEORETICAL; PHARMACOKINETICS; PHARMACOLOGY; THERMODYNAMICS;

EID: 0032843702     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357991773465     Document Type: Article

References (24)

1. Bach, M. (1995) Einfluß von potentiellen lipophilen Penetrationsbeschleunigern auf die Wirkung von Modellarzneistoffen. PhD Thesis, Heinrich Heine Universität, Düsseldorf
2. Bach, M., Lippold, B. C. (1998a) Influence of penetration enhancers on the blanching intensity of betamethasone 17-benzoate. Int. J. Pharm. 168: 97-108
3. Bach, M., Lippold, B. C. (1998b) Penetration enhancement and its quantification. Eur, J. Pharm. Biopharm. 46: 1-13
4. Barry, B. W., Woodford, R. (1978) Activity and bioavailability of topical steroids. In vivo/in vitro correlations for the vasoconstrictor assay. J. Clin. Pharm. 3: 43-65
5. Crank, J. (1956) Mathematics of Diffusion. Oxford University Press, London
6. FDA (1995) Topical Dermatologic Corticosteroids: In Vivo Bioequivalence. Guidance for Industry
7. Flynn, G. L., Roseman, T. J. (1971) Membrane diffusion II: influence of physical adsorption on molecular flux through heterogeneous dimethylpolysiloxane barriers. J. Pharm. Sci. 60: 1788-1796
8. Goodman, M., Barry, B. W. (1988) Action of penetration enhancers on human skin as assessed by the permeation of model drugs 5-fluorouracil and estradiol. I. Infinite dose technique. J. Invest. Dermatol. 91: 323-327
9. Haleblian, J. K. (1976) Bioassays used in development of topical dosage forms. J. Pharm. Sci. 65: 1417-1436
10. Kadir, R., Stempler, D., Liron, Z., Cohen, S. (1988) Penetration of adenosine into excised human skin from binary vehicles: the enhancement factor. J. Pharm. Sci. 77: 409-413
11. Le, V. H. (1993) Einfluß von Substanzeigenschaften auf Permeabilität und maximalen Flux von homologen Nicotinsäureestern in vitro und an der Haut in vivo. PhD Thesis, Heinrich Heine University, Düsseldorf
12. Leopold, C. S. (1998a) How accurate is the determination of the relative bioavailability of transdermal drug formulations from pharmacodynamic response data? Pharm. Acta Helv. 73: 63-67
13. Leopold, C. S. (1998b) Quantification of depletion in solution-type topical preparations in vivo. J. Cosmet. Sci. 49: 165-174
14. Leopold, C. S., Lippold, B. C. (1995) Enhancing effects of lipophilic vehicles on skin penetration of methyl nicotinate in vivo. J. Pharm. Sci. 84: 195-198
15. Leopold, C. S., Maibach, H. I. (1999) Percutaneous penetration of local anesthetic bases: pharmacodynamic measurements. J. Invest. Dermatol. In press
16. Levy, G. (1966) Kinetics of pharmacologic effects. Clin. Pharmacol. Ther. 7: 362-371
17. Lippold, B. C., Reimann, H. (1989a) Wirkungsbeeinflussung bei Lösungssalben durch Vehikel am Beispiel von Methylnicotinat, Teil I: Relative thermodynamische Aktivität des Arzneistoffes in verschiedenen Vehikeln und Freisetzungsverhalten. Acta Pharm. Technol. 35: 128-135
18. Lippold, B. C., Reimann, H. (1989b) Wirkungsbeeinflussung bei Lösungssalben durch Vehikel am Beispiel von Methylnicotinat, Teil II: Beziehung zwischen relativer thermodynamischer Aktivität und Bioverfügbarkeit: Penetrationsbeschleunigung und Entleerungseffekt. Acta Pharm. Technol. 35: 136-142
19. Lippold, B. C., Schneemann, H. (1984) The influence of vehicle on the local bioavailability of betamethason-17-benzoate from solution-and suspension-type ointments. Int. J. Pharm. 22: 31-43
20. Lippold, B. C., Teubner, A. (1981a) Biopharmazeutische Qualität von Arzneiformen, insbesondere für lokale Anwendung, abgeleitet aus Wirkungsmessungen. Pharm. Ind. 43: 71-73
21. Lippold, B. C., Teubner, A. (1981b) Einfluß verschiedener Salbengrundlagen auf die Wirkung von Nicotinsäurebenzylester in Lösungssalben. Pharm. Ind. 43: 1123-1133
22. McKenzie, A. W., Stoughton, R. B. (1962) Method for comparing percutaneous absorption of steroids. Arch. Dermatol. 86: 608-610
23. Naito, S. I., Tsai, Y. H. (1981) Percutaneous absorption of indomethacin from ointment bases in rabbits. Int. J. Pharm. 8: 263-276
24. Stoughton, R. B. (1969) Bioassay methods for measuring percutaneous absorption. In: Montagna, W., van Scott, E. J., Stoughton, R. B. (eds) Advances in the Biology of Skin. Appleton, New York, pp 542-573