The 2-pyridone antibacterial agents: 8-Position modifications

Current Pharmaceutical Design

Volumn 5, Issue 7, 1999, Pages 515-543

  Fung, Anthony K L ^a   Shen, Linus L ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 PYRIDONE DERIVATIVE; 8 (3 AMINO 1 PYRROLIDINYL) 1 CYCLOPROPYL 7 FLUORO 9 METHYL 4 OXO 3 QUINOLIZINECARBOXYLIC ACID; 8 (4 METHYLPIPERAZINE 1 YL) 1 ETHYL 7 FLUORO 4H 4 OXOQUINOLIZINE 3 CARBOXYLIC ACID; A 165753; A 170568; CIPROFLOXACIN; CYCLOPHOSPHAMIDE; DNA TOPOISOMERASE (ATP HYDROLYSING); OFLOXACIN; PEFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TROVAFLOXACIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ANAEROBIC BACTERIUM; BACTERICIDAL ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; INFECTION; INTRAPERITONEAL DRUG ADMINISTRATION; LD 50; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MODEL; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBCUTANEOUS DRUG ADMINISTRATION;

ANTI-BACTERIAL AGENTS; BACTERIA; FLUOROQUINOLONES; PYRIDONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032840653     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (25)

1. Jones, R.N.; Marshal, S.A.; Pfaller, M.A.; Wilke, W.W.; Hollis, R.J.; Erwin, M.E.; Edmond, M.B.; Wenzel, R.P.; and the SCOPE Hospital Study Group. Diagn Microbial Infect. Dis., 1997, 29, 95-102.
2. Brighty, K.E.; Kohlbrenner, W.; Mcguirk, P.R. Annual Reports Med. Chem., 1993, 28, 141.
3. Li, Q.; Claiborne, A.; Chu, D.T.W.; Lee, C.M.; Raye, K.A.; Berst, K.; Ma, Z.; Wang, W.; Shen, L.L.; Flamm, R.; Nilius, A.; Alder, J.; Marsh, K.; Shortridge, V.D.; Tanaka, S.K.; Seif, L.; Cooper, C.; Fung, A.K.L.; Tufano, M.; Melcher, L.M.; Henry, R.; Klein, L.; Plattner, J.J. 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1995, paper F8.
4. Gootz, T.D.; Brigty, K.E. Med. Res. Rev., 1996, 16, 433.
5. Li, Q.; Chu, D.T.W.; Claiborne, A.; Cooper, C.; Lee, C.M.; Raye, K.; Berst, K.; Pamela, D.; Wang, W.; Haswold, L.; Fung, A.K.L.; Ma, Z.; Tufano, M.; Flamm, R.; Shen, L.L.; Baranowski, J.; Nilius, A.; Alder, J.; Meulbroek, J.; Marsh, K.; Crowell, D.; Hui, Y.; Seif, L.; Melcher, L.M.; Henry, R.; Spanton, S.; Faghih, R.; Klien, L.; Tanaka, S.K.; Plattner, J.J. J. Med. Chem., 1996, 39, 3070-3088.
6. Klein, L.L.; DeGoey, D.A.; Thomas, S.A.; Yeung, C.M.; Leone, C.L.; Grampovnik, D.; Lartey, P.A. Bioorg. Med. Chem. Lett., 1997, 7, 1167.
7. Wang, W.; Kerdesky, F.A.; Hsiao, C.W.; Chu, D.T. 1997, US Patent, 5,693,813.
8. Shen, L.L.; Mitscher, L.A.; Sharma, P.N.; O'Donnell, T.J.; Chu, D.W.T.; Cooper, C.S.; Rosen, T.; Pernet, A.G. Biochem., 1989, 28, 3886-3894.
9. Shen, L.L.; Chu, D.T.W. Current Pharmaceutical Design, 1996, 2, 195-208.
10. a. Chu, D.T.W.; Li, Q.; Claiborne, A.; Raye, K.; Cooper, C.; Fung, A.; Lee, C.; Tanaka, K.; Shen, L.L.; Donner, P.; Armiger, Y.; Plattner, J.J. 34th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1994, paper F41.
11. b. Fung, A.K.L.; Chu, D.T.W.; Armiger, Y.L.; Li, Q.; Tanaka, S.K.; Flamm, R.K.; Shen, L.L.; Baranowsky, J.; Marsh, K.; Crowell, D.; Plattner, J.J. 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1995, paper F9.
12. Ma, Z.; Chu, D.T.W.; Li, Q.; Shen, L.L.; Fung, A.K.L.; Cooper, C.S.; Wang, W.; Wang, S.; Flamm, R.K.; Nilius, A.; Alder, J.D.; Tanaka, S.K.; Or, Y.; Platnner, J.J. 37th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1997, paper F169.
13. Armiger, Y.L.; Chu, D.T.W.; Fung, A.K.L.; Li, Q.; Wang, W.B.; Nilius, A.; Alder, J.; Ewing, P.; Stone, G.; Meulbroek, J.; Bui, M.; Shen, L.L.; Paige, L.; Or, Y.S.; Plattner, J.J. 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1998, paper F86.
14. a. Hagen, S.E.; Domagala, J.M.; Grachek, S.J.; Sesnie, J.A. ; Stier, M.A.; Suto, M.J. J. Med. Chem., 1994, 37, 733-738
15. b. Plummer, J.S.; Emery, L.A.; Stier, M.A.; Suto, M.J. Tetrahedron Letters, 1993, Vol. 34, No. 47, 7529-7532.
16. Kimura, Y.; Atarashi, S.; Takahashi, M.; Hayakawa, I. Chem. Pharm. Bull., 1994, 42(7), 1442-1454.
17. Schenke et al. 1991, US patent 5,071 999.
18. Bayer AG. 1993, European patent 0 550 903 Al.
19. Cesare, P.D.; Bouzard, D.; Essiz, M.; Jacquet, L.P.; Ledoussal, B.; Kiechel, J.R.; Remuzon, P.; Kessler, R.E.; Fung-Tome, J.; Desiderio, J. J. Med. Chem., 1992, 35, 4205-4213.
20. Schroeder, M.C.; Kiely, J.S.; Laborde, E.; Johnson, D.R.; Szotek, D.L.; Domagala, J.M.; Stickney, T.M. J. Heterocyclic Chem., 1992, 29, 1481-1498.
21. Cornett, J.B.; Wentland, M.P. Annu. Rep. Med. Chem., 1986, 21, 139-148.
22. Takahaski, H.; Kawakami, K.; Sugita, K.; Ohki, H.; Kimura, K.; Miyauchi, R.; Sato, K.; Takemura, M. 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1998, paper F73.
23. Ma, Z.; Wang, S.; Cooper, C.S.; Fung, A.K.L.; Lynch, J.K.; Plagge, F.; Chu, D.T.W. Tetrahedron: Asymmetry, 1997, 8, 883.
24. Kimura, Y.; Atarashi, S.; Kawakami, K.; Sato, K.; Hayakawa, I. J. Med. Chem., 1994, 37, 3344-3352.
25. Meulbroek, J.; Jarvis, K.; Mitten, M.; Oleksijew, A.; Alder, J.; Stone, G.; Nilius, A.; Flamm, R.; Armiger, Y.L.; Fung, A.; Or, Y.S.; Chu, D.; Plattner, JJ. 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, 1998, paper F81.