Training dose as a decisive factor for discrimination of a drug mixture in rats

Behavioural Pharmacology

Volumn 7, Issue 4, 1996, Pages 364-372

  Mariathasan, E A ^a   White, J A W ^a   Stolerman, I P ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Amphetamine; Apomorphine; Drug discrimination; Nicotine; Pentobarbitone; Rat

Indexed keywords

AMPHETAMINE; APOMORPHINE; NICOTINE; PENTOBARBITAL;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DOSE RESPONSE; DRUG DISCRIMINATION; DRUG MIXTURE; FOOD; INSTRUMENTAL CONDITIONING; MALE; NONHUMAN; RAT; REINFORCEMENT; STIMULUS GENERALIZATION; SUBCUTANEOUS DRUG ADMINISTRATION; TECHNIQUE; TRAINING;

EID: 0029815928     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008877-199608000-00008     Document Type: Article

References (22)

1. Chance WT, Murfin D, Krynock GM and Rosecrans JA (1977) A description of the nicotine stimulus and tests of its generalization to amphetamine. Psychopharmacology, 55, 19-26.
2. Colpaert FC, Niemegeers CJE and Janssen PAJ (1980) Factors regulating drug cue sensitivity: the effect of training dose in fentanyl-saline discrimination. Neuropharmacology, 19, 705-713.
3. De Vry J and Slangen JL (1986) Effects of chlordiazepoxide training dose on the mixed agonist-antagonist properties of benzodiazepine receptor antagonist Ro 15-1788, in a drug discrimination procedure. Psychopharmacology, 88, 177-183.
4. Druhan JP, Fibiger HC and Phillips AG (1991) Influence of some drugs of abuse on the discriminative stimulus properties of amphetamine. Behavioural Pharmacology, 2, 391-403.
5. Duncan PM (1986) The effect of training dose on discrimination of compound drug-exteroceptive stimuli. Psychopharmacology, 90, 543-547.
6. Garcha HS and Stolerman IP (1989) Discrimination of a drug mixture in rats: role of training dose, and specificity. Behavioural Pharmacology, 1, 25-31.
7. Gauvin DV and Holloway FA (1993) The discriminative stimulus properties of an ethanol-nicotine mixture in rats. Journal of Psychopharmacology, 7, 52-62.
8. Gauvin DV, Moore KR, Youngblood BD and Holloway FA (1993) The discriminative stimulus properties of legal, over-the-counter stimulants administered singly and in binary and ternary combinations. Psychopharmacology, 110, 309-319.
9. Järbe TUC, Kujansuu M and Mathis DA (1994) Differential control of responding by drug and visual cues in a two-choice discrimination task for rats. In: Problems of Drug Dependence 1993. NIDA Research Monograph 141 (Ed LS Harris), p. 296. National Institute on Drug Abuse, Rockville, MD.
10. Mariathasan EA, Garcha HS and Stolerman IP (1991) Discriminative stimulus effects of amphetamine and pentobarbitone separately and as mixtures in rats. Behavioural Pharmacology, 2, 405-415.
11. Mariathasan EA and Stolerman IP (1994) Functional relationships, previous history and the discrimination of a drug mixture in rats. Drug and Alcohol Dependence, 35, 117-125.
12. Rushton R and Steinberg H (1963) Mutual potentiation of amphetamine and amylobarbitone measured by activity in rats. British Journal of Pharmacology and Chemotherapy, 21, 295-305.
13. Rutledge CO and Kelleher RT (1965) Interactions between the effects of methamphetamine and pentobarbital on operant behavior in the pigeon. Psychopharmacologia, 7, 400-408.
14. Shannon HE and Holtzman SG (1979) Morphine training dose: a determinant of stimulus generalization to narcotic antagonists in the rat. Psychopharmacology, 61, 239-244.
15. Steinberg H, Rushton R and Tinson C (1961) Modification of the effects of an amphetamine-barbiturate mixture by the past experience of rats. Nature, 192, 533-535.
16. Stolerman IP (1989) Discriminative stimulus effects of nicotine in rats trained under different schedules of reinforcement. Psychopharmacology, 97, 131-138.
17. Stolerman IP and D'Mello GD (1981) Role of training conditions in discrimination of central nervous system stimulants by rats. Psychopharmacology, 73, 295-303.
18. Stolerman IP, Garcha HS, Pratt JA and Kumar R (1984) Role of training dose in discrimination of nicotine and related compounds by rats. Psychopharmacology, 84, 413-419.
19. Stolerman IP, Mariathasan EA and White J-AW (1995) Training dose as a determinant of stimulus generalization with a mixture of drugs. Society for Neuroscience Abstracts, 21, 1625.
20. White FJ and Appel JB (1982) Training dose as a factor in LSD-saline discrimination. Psychopharmacology, 76, 20-25.
21. Witkin JM, Carter RB, Dykstra LA (1980) Discriminative stimulus properties of d-amphetamine-pentobarbital combinations. Psychopharmacology, 68, 269-276.
22. Young AM, Masaki MA and Geula C (1992) Discriminative stimulus effects of morphine: effects of training dose on agonist and antagonist effects of mu opioids. Journal of Pharmacology and Experimental Therapeutics, 261, 246-257.