Antibodies to a merozoite surface protein promote multiple invasion of red blood cells by malaria parasites

Parasite Immunology

Volumn 21, Issue 8, 1999, Pages 397-407

  Ramasamy, R ^a   Yasawardena, S ^a   Kanagaratnam, R ^a   Buratti, E ^b   Baralle, F E ^b   Ramasamy, M S ^a  

^a INSTITUTE OF FUNDAMENTAL STUDIES   (Sri Lanka)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

Antibodies; Complement; Erythrocyte invasion; Immune evasion; Malaria; Merozoite; Merozoite surface antigen; Plasmodium falciparum; Vaccine

Indexed keywords

ANTIBODY; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G; MALARIA VACCINE; MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; CELL CULTURE; CELL INVASION; CONTROLLED STUDY; CROSS LINKING; ERYTHROCYTE; EXPRESSION VECTOR; GENE AMPLIFICATION; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOFLUORESCENCE; MEROZOITE; MOLECULAR CLONING; NONHUMAN; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SCHISTOSOMA JAPONICUM; WESTERN BLOTTING;

ANIMALS; ANTIBODIES; ANTIBODIES, PROTOZOAN; ANTIBODY FORMATION; ANTIBODY SPECIFICITY; ANTIGENS, PROTOZOAN; ANTIGENS, SURFACE; ERYTHROCYTES; HUMANS; IMMUNIZATION; INFECTION; MALARIA; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; RABBITS; RECOMBINANT FUSION PROTEINS;

ANIMALIA; BACTERIA (MICROORGANISMS); ORYCTOLAGUS CUNICULUS; PLASMODIUM FALCIPARUM; PROTOZOA; SCHISTOSOMA JAPONICUM;

EID: 0032839755     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.1999.00239.x     Document Type: Article

References (41)

1. Aikawa M., Miller L.H., Johnson, J. & Rabbege, J. (1978) Erythrocyte entry by malarial parasites - a moving junction between erythrocyte and parasite. Journal of Cell Biology 77, 72-82
2. Al-Yaman F., Genton B., Anders R.F.et al. (1995) Assessment of the role of the humoral immune response to Plasmodium falciparum MSP2 compared to RESA and SPf66 in protecting Papua New Guinean children from clinical malaria. Parasite Immunology 17, 493-501
3. Blackman M.J., Scott-Finnigan T.J., Shai S. & Holder A.A. (1994) Antibodies inhibit the protease-mediated processing of a malaria merozoite surface protein. Journal of Experimental Medicine 180, 389-393
4. Bouharoun-Tayoun H., Oeuvray C., Lunel F. & Druilhe P. (1995) Mechanisms underlying the monocyte mediated antibody dependent killing of Plasmodium falciparum asexual blood stages. Journal of Experimental Medicine 182, 409-418
5. Braun-Breton C., Blisnick T., Barbot P.et al. (1992) Plasmodium falciparum and Plasmodium chabaudi: characterisation of glycosylphosphatidyl inositol-degrading activities. Experimental Parasitology 74, 452-462
6. Egan A.F., Morris J., Barnish G.et al. (1996) Clinical immunity to Plasmodium falciparum malaria is associated with serum antibodies to the 19kDa C-terminal fragment of the merozoite surface antigen PfMSP-1. Journal of Infectious Diseases 173, 765-769
7. Epping R.J., Goldstone S.D., Ingram L.T.et al. (1988) An epitope recognised by inhibitory monoclonal antibodies that react with a 51 kilodalton merozoite surface antigen in Plasmodium falciparum. Molecular and Biochemical Parasitology 28, 1-10
8. Fenton B., Clark J.T., Wilson C.F., McBride, J.S. & Walliker D. (1991) Polymorphism of a 35-48 kDa Plasmodium falciparum merozoite surface antigen. Molecular and Biochemical Parasitology 34, 79-86
9. Franzen L., Wahlin B., Wahlgren M.et al. (1989) Enhancement or inhibition of Plasmodium falciparum crythrocyte reinvasion by antibodies to an asparagine rich protein. Molecular and Biochemical Parasitology 32, 201-212
10. Good M.F., Kaslow D.C. & Miller L.H. (1998) Pathways and strategies for developing a malaria blood-stage vaccine. Annual Review of Immunology 16, 57-87
11. Groux H. & Gysin J. (1990) Opsonisation as an effector mechanism in human protection against asexual stages of Plasmodium falciparum; functional role of IgG subclasses. Research in Immunology 141, 529-542
12. Harlow E. & Lane D. (1988) Antibodies - A Laboratory Manual. Cold Spring, Harbour Laboratory Press, Cold Spring, Harbour, USA
13. Kanagaratnam R., Misiura K., Rebowski, G. & Ramasamy, R. (1998) Malaria merozoite surface protein antisense oligodeoxynucleotides lack antisense activity but function as polyanions to inhibit red cell invasion. International Journal of Biochemistry and Cell Biology 30, 979-985
14. Kumaratilake L.M., Ferrante A., Jaeger T. & Rzepczyk C.M. (1996) GM-CSF induced priming of human neutrophils for enhanced phagocytosis and killing of asexual stages of Plasmodium falciparum: synergistic effects of GM-CSF and TNF. Parasite Immunology 18, 115-123
15. Laemmli U.K. (1970) Cleavage of structural proteins during the assembly of the head of the bacteriophage T4. Nature 227, 760-762
16. Lowry O.H., Rosebrough N.J., Farr, A.L. & Randall, R.J. (1951) Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193, 265-275
17. Lyon J.A., Haynes J.D., Diggs C.L., Chulay J.D. & Pratt-Rossiter J.M. (1986) Plasmodium falciparum antigens synthesised by schizonts and stabilised at the merozoite surface by antibodies when schizonts mature in the presence of growth inhibitory serum. Journal of Immunology 136, 2252-2258
18. Marshall V.M., Wu T.Q. & Coppel R.L. (1998) Close linkage of three merozoite surface protein genes on chromosome 2 of Plasmodium falciparum. Molecular and Biochemical Parasitology 94, 13-25
19. Miller L.H., David P.H., Hudson D.E.et al. (1984) Monoclonal antibodies to a 140 000 mw protein of Plasmodium knowlesi merozoites inhibit their invasion of rhesus erythrocytes. Journal of Immunology 132, 438-442
20. Oeuvray C., Bouharoun-Tayoun H., Gras-Masse H.et al. (1994) Merozoite surface protein-3: a malaria protein inducing antibodies that promote Plasmodium falciparum killing by cooperation with blood monocytes. Blood 84, 1594-1602
21. Patino J.A.G., Holder A.A., McBride J.S. & Blackman M.J. (1997). Antibodies that inhibit malaria merozoite surface protein-1 processing and erythrocyte invasion are blocked by naturally acquired human antibodies. Journal of Experimental Medicine 186, 1689-1699
22. Ramasamy R. (1987) Studies on glycoproteins in the human malaria parasite Plasmodium falciparum - the identification of a myristilated 45kDa merozoite membrane glycoprotein. Immunology and Cell Biology 65, 419-424
23. Ramasamy R. (1998) Molecular basis for evasion of host immunity and pathogensis in malaria. Biochimica Biophysica Acta 1406, 10-27
24. Ramasamy R. & Geysen H.M. (1990) Novel cross-reactive epitopes on asexual blood stage antigens of Plasmodium falciparum. Parasite Immunology 12, 457-471
25. 35S]dATP demonstrates polymorphism of a surface antigen in malaria parasites from Sri Lankan patients. Biochimica et Biophysica Acta 1227, 28-32
26. Ramasamy. R. & Rajakaruna R. (1997) Association of malaria with α1,3 galactosyl transferase inactivation in catarrhines. Biochimica et Biophysica Acta 1360, 241-246
27. Ramasamy. R. & Wickremaratne C., (1994) Influence of N-terminal amino acids and conjugation position to carrier of specificities of antibodies elicited by malaria peptides. Indian Journal of Medical Research 99, 21-26
28. Ramasamy R., Jones G. & Lord R. (1990) Characterisation of an inhibitory monoclonal antibody defined epitope on a malaria vaccine candidate antigen. Immunology Letters 23, 305-310
29. Ramasamy R., Wijesunderc D.S., Nagendran K. & Ramasamy M.S. (1995) Antibody and clinical responses in volunteers to immunisation with malaria peptide-diphtheria toxoid conjugates. Clinical and Experimental Immunology 99, 168-174
30. Ramasamy R., Kanagaratnam R., Misiura K.et al. (1996) Anti-sense oligonucleoside phosphorothiotes non-specifically inhibit invasion of red blood cells by malaria parasites. Biochemical Biophysical Research Communications 218, 930-933
31. Ramasamy R., Yasawardena S.G., Kanagaratnam R.et al. (1999) Mammalian cell expression of malaria merozoite surface proteins and experimental DNA and RNA immunisation. Biochimica et Biophysica Acta 1453, 1-13
32. Ranford-Cartwright L.C., Taylor R.R., Asgari-Jirhandeh N.et al. (1996) Differential antibody recognition of FC27-like Plasmodium falciparum merozoite surface protein MSP2 antigens which lack 12 amino acid repeats. Parasite Immunology 18, 411-420
33. Robson K.J.H., Naitzia S., Barker G., Sinden, R.E. & Crisanti A. (1997) Cloning and expression of the thrombospondin related adhesive protein gene of Plasmodium berghei. Molecular and Biochemical Parasitology 84, 1-12
34. Sambrook J., Fritsch E.F. & Maniatis T. (1989) Molecular Cloning - A Laboratory Manual. Cold Spring, Harbour Laboratory Press, Cold Spring, Harbour, USA
35. Smythe J.A., Coppel R.L., Brown G.V.et al. (1988) Identification of two integral membrane proteins of Plasmodium falciparum. Proceedings of the National Academy of Sciences USA 85, 5195-5199
36. Smythe J.A., Peterson M.G., Coppel R.L. et al. (1990) Structural diversity in the 45-kilodalton merozoite surface antigen of Plasmodium falciparum. Molecular and Biochemical Parasitology 39, 227-234
37. Sturchler D., Berger R., Rudin C.et al. (1995) Safety, immunogenicity, and pilot efficacy of Plasmodium falciparum sporozoite and asexual blood-stage combination vaccine in Swiss adults. American Journal of Tropical Medicine and Hygiene. 53, 423-431
38. Taylor R.R., Smith D.B., Robinson V.J., Mcbride J.S. & Riley E.M. (1995) Human antibody response to Plasmodium falciparum merozoite surface protein 2 is serogroup specific and predominantly of the G3 subclass. Infection and Immunity 63, 4382-4388
39. Thomas A.W., Carr D.A., Carter M.J. & Lyon J.A. (1990) Sequence comparision of allelic forms of the Plasmodium falciparum merozoite surface antigen MSA2. Molecular and Biochemical Parasitology 43, 211-220
40. Tomlinson S. & Raper J. (1998) Natural human immunity to trypanosomes. Parasitology Today 14, 354-359
41. Towbin H., Staehelin T. & Gordon J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. Procedures and some applications. Proceedings of the National Academy of Sciences USA 76, 4350-4354