Endothelial haemostatic factors are associated with progression of urinary albumin excretion in clinically healthy subjects: A 4-year prospective study

Clinical Science

Volumn 97, Issue 1, 1999, Pages 37-43

  Clausen, Peter ^a   Feldt Rasmussen, Bo ^a   Jensen, Gorm ^b   Jensen, Jan Skov ^b  

^a Rigshospitalet   (Denmark)

^b BISPEBJERG HOSPITAL   (Denmark)

Author keywords

Atherosclerosis; Cardiovascular disease; Cardiovascular risk factor; Endothelial dysfunction; Microalbuminuria; Tissue plasminogen activator; Urinary albumin excretion; von Willebrand factor

Indexed keywords

ALBUMIN; BIOCHEMICAL MARKER; BLOOD CLOTTING FACTOR 7; CHOLESTEROL; FIBRINOGEN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLASMINOGEN ACTIVATOR INHIBITOR; TISSUE PLASMINOGEN ACTIVATOR; TRIACYLGLYCEROL; VON WILLEBRAND FACTOR;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CELL SECRETION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; DISEASE COURSE; ENDOTHELIUM CELL; FEMALE; GLUCOSE BLOOD LEVEL; HEMOSTASIS; HUMAN; HUMAN EXPERIMENT; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; NORMAL HUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; URINARY EXCRETION;

ADULT; AGED; ALBUMINURIA; BIOLOGICAL MARKERS; ENDOTHELIUM, VASCULAR; HEMOSTASIS; HUMANS; MIDDLE AGED; PROSPECTIVE STUDIES; TISSUE PLASMINOGEN ACTIVATOR; VON WILLEBRAND FACTOR;

EID: 0032839631     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS19990002     Document Type: Article

References (43)

1. Viberti, G. C., Hill, R. D., Jarret, R. J., Argyropoulos, A., Mahmud, U. and Keen, H. (1982) Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus. Lancet i, 1430-1432
2. Deckert, T., Yokoyama, H., Mathiesen, E. et al. (1996) Cohort study of predictive value of urinary albumin excretion for atherosclerotic vascular disease in patients with insulin dependent diabetes. Br. Med. J. 312, 871-874
3. Dinneen, S. F. and Gerstein, H. C. (1997) The association of microalbuminuria and mortality in non-insulin-dependent diabetes mellitus. Arch. Intern. Med. 157, 1413-1418
4. Yudkin, J. S., Forrest, R. D. and Jackson, C. A. (1988) Microalbuminuria as predictor of vascular disease in non-diabetic subjects: Islington Diabetes Survey. Lancet ii, 530-533
5. Damsgaard, E. M., Froøland, A., Jørgensen, O. D. and Mogensen, C. E. (1990) Microalbuminuria as predictor of increased mortality in elderly people. Br. Med. J. 300, 297-300
6. Kuusisto, J., Mykkänen, L., Pyorala, K. and Saakso, M. (1995) Hyperinsulinemic microalbuminuria. A new risk indicator for coronary heart disease. Circulation 91, 831-837
7. Borch-Johnsen, K., Feldt-Rasmussen, B., Strandgaard, S., Schroll, M. and Jensen, J. S. (1999) Urinary albumin excretion: an independent predictor of ischemic heart disease. Arterioscler. Thromb. Vasc. Biol. in the press
8. Haffner, S. M., Stern, M. P., Gruber, M. K. K., Hazuda, H. P., Mitchell, B. D. and Patterson, J. K. (1990) Microalbuminuria. Potential marker for increased cardiovascular risk factors in nondiabetic subjects? Arteriosclerosis 10, 727-731
9. Jensen, J. S., Borch-Johnsen, K., Jensen, G. and Feldt-Rasmussen, B. (1995) Atherosclerotic risk factors are increased in clinically healthy subjects with microalbuminuria. Atherosclerosis 112, 245-252
10. Clausen, P., Jensen, J. S., Borch-Johnsen, K., Jensen, G. and Feldt-Rasmussen, B. (1998) Ambulatory blood pressure and urinary albumin excretion in clinically healthy subjects. Hypertension 32, 71-77
11. Feldt-Rasmussen, B. (1986) Increased transcapillary escape rate of albumin in type 1 (insulin-dependent) diabetic patients with microalbuminuria. Diabetologia 29, 282-286
12. Norgaard, K., Jensen, T. and Feldt-Rasmussen, B. (1993) Transcapillary escape rate of albumin in hypertensive patients with type 1 (insulin-dependent) diabetes mellitus. Diabetologia 36, 57-61
13. Jensen, J. S. (1995) Renal and systemic transvascular albumin leakage in severe atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 15, 1324-1329
14. Jensen, J. S., Borch-Johnsen, K., Jensen, G. and Feldt-Rasmussen, B. (1995) Microalbuminuria reflects a generalized transvascular albumin leakiness in clinically healthy subjects. Clin. Sci. 88, 629-633
15. Vane, J. R., Angaard, E. E. and Botting, R. M. (1990) Mechanisms of disease: regulatory functions of the vascular endothelium. N. Engl. J. Med. 323, 27-36
16. Ross, R. (1986) The pathogenesis of atherosclerosis - an update. N. Engl. J. Med. 314, 488-500
17. Lip, G. Y. H. and Blann, A. (1997) von Willebrand factor: a marker of endothelial dysfunction in vascular disorders? Cardiovasc. Res. 34, 255-265
18. Jensen, T. (1989) Increased plasma concentration of von Willebrand Factor in insulin dependent diabetics with incipient nephropathy. Br. Med. J. 298, 27-28
19. Chen, J. W., Gall, M. A., Deckert, M., Jensen, J. S. and Parving, H.-H. (1995) Increased serum concentration of von Willebrand Factor in non-insulin dependent diabetic patients with and without diabetic nephropathy. Br. Med. J. 311, 1405-1406
20. Stehouwer, C. D. A., Fischer, H. R. A., van Kuijk, A. W. R., Polak, B. C. P. and Donker, J. M. (1995) Endothelial dysfunction precedes development of microalbuminuria in IDDM. Diabetes 44, 561-564
21. Stehouwer, C. D. A., Nauta, J. J. P., Zeldenrust, G. C., Hackeng, W. H. L., Donker, A. J. M. and Den Ottolander, G. J. H. (1992) Urinary albumin excretion, cardiovascular disease, and endothelial dysfunction in non-insulin-dependent diabetes mellitus. Lancet 340, 319-323
22. Pedrinelli, R., Giampietro, O., Carmassi, F. et al. (1994) Microalbuminuria and endothelial dysfunction in essential hypertension. Lancet 344, 14-18
23. Jensen, G. (1983) Epidemiology of chest pain and angina pectoris - with special reference to treatment needs. Acta Med. Scand. 214 (Suppl. 682), 1-120
24. Jensen, J. S., Borch-Johnsen, K., Feldt-Rasmussen, B., Appleyard, M. and Jensen, G. (1997) Urinary albumin excretion and history of acute myocardial infarction in a cross-sectional population study of 2613 individuals. J. Cardiovasc. Risk 4, 121-125
25. Ingerslev, J. A. (1987) A sensitive ELISA for von Willebrand Factor (vWf:Ag). Scand. J. Clin. Lab. Invest. 47, 143-149
26. Lund-Hansen, T., Olsen, A. A. and Selmer, J. (1989) A double monoclonal ELISA for human coagulation factor VII. Thromb. Haemost. 62, 55
27. Bergsdorf, N., Nilsson, T. and Wallen, P. (1983) An enzyme linked immunosorbent assay for determination of tissue plasminogen activator applied to patients with thromboembolic disease. Thromb. Haemost. 50, 740-744
28. Declerck, P. J., Alessi, M. G., Verstreken, M., Kruithof, E. K. O., Juhan-Vague, I. and Collen, D. (1988) Measurement of plasminogen activator inhibitor 1 in biologic fluids with a murine monoclonal antibody-based enzyme-linked immunosorbent assay. Blood 71, 220-225
29. Broze, G. and Majerus, P. W. (1981) Human factor VII. Methods Enzymol. 80, 228-237
30. Jacobsen, K. (1955) Method for determination of fibrinogen in plasma. Scand. J. Clin. Lab. Invest. 14 (Suppl.), 14-16
31. Feldt-Rasmussen, B., Dinesen, B. and Deckert, M. (1985) Enzyme immunoassay: an improved determination of urinary albumin in diabetics with incipient nephropathy. Scand. J. Clin. Lab. Invest. 45, 539-544
32. 2-microglobulin in urine and serum determined by a micro-ELISA technique. Scand. J. Clin. Lab. Invest. 46, 791-793
33. Broøchner-Mortensen, J. (1972) A simple method for the determination of glomerular filtration rate. Scand. J. Clin. Lab. Invest. 30, 271-274
34. Broøchner-Mortensen, J. (1980) A simple single injection method for determination of the extracellular fluid volume. Scand. J. Clin. Lab. Invest. 40, 567-573
35. Jensen, J. S. (1995) Intra-individual variation of overnight urinary albumin excretion in clinically healthy middle-aged individuals. Clin. Chim. Acta 243, 95-99
36. Vaughan, D. E. (1998) Fibrinolytic balance, the renin-angiotensin system and atherosclerotic disease. Eur. Heart J. 19 (Suppl G), G9-G12
37. Juhan-Vague, I., Alessi, M. C. and Vague, P. (1996) Thrombogenic and fibrinolytic factors and cardiovascular risk in non-insulin-dependent diabetes mellitus. Ann. Med. 28, 371-380
38. Suffredini, J. H., Harpel, P. C. and Parrillo, J. E. (1989) Promotion and subsequent inhibition of plasminogen activation after administration of intravenous endotoxin to normal subjects. N. Engl. J. Med. 320, 1165-1172
39. Kristensen, P., Larsson, L. I., Nielsen, L. S., Grondahl-Hansen, J., Andreasen, P. A. and Dano, K. (1984) Human endothelial cells contain one type of plasminogen activator. FEBS Lett. 168, 33-37
40. Blann, A. D. and Taberner, D. A. (1995) A reliable marker of endothelial cell dysfunction: does it exist? Br. J. Haematol. 90, 244-248
41. Jansson, J. H., Nilsson, T. K. and Johnson, O. (1991) Von Willebrand factor in plasma: a novel risk factor for recurrent myocardial infarction and death. Br. Heart J. 66, 351-355
42. Ridker, P. M., Vaughan, D. E., Stampfer, M. J., Manson, J. E. and Hennekens, C. H. (1993) Endogenous tissue type plasminogen activator and risk of myocardial infarction. Lancet 341, 1165-1168
43. Steinberg, H. O., Bayazeed, B., Hook, G., Johnson, A., Cronin, J. and Baron, A. D. (1997) Endothelial dysfunction is associated with cholesterol levels in the high normal range in humans. Circulation 96, 3287-3293