Estrogenic potencies of several environmental pollutants, as determined by vitellogenin induction in a carp hepatocyte assay

Toxicological Sciences

Volumn 50, Issue 2, 1999, Pages 206-213

  Smeets, Jean M W ^a   Van Holsteijn, Ineke ^a   Giesy, John P ^b   Seinen, Willem ^a   Van Den Berg, Martin ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

(anti)estrogens; Bisphenol A; Chlordecone; Fish; Hepatocytes; In vitro; Methoxychlor; Vitellogenin

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 4,4' ISOPROPYLIDENEDIPHENOL; CAMPHECLOR; CHLORDECONE; CHLORPHENOTANE; CYTOCHROME P450; DIELDRIN; ENDOSULFAN; ESTRADIOL; ETHOXYRESORUFIN; METHOXYCHLOR; VITELLOGENIN;

ACCURACY; ANIMAL CELL; ARTICLE; CARP; CELL CULTURE; CONTROLLED STUDY; ENZYME INDUCTION; ESTROGEN ACTIVITY; LIVER CELL; MALE; NONHUMAN; VITELLOGENESIS;

ANIMALS; CARPS; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENVIRONMENTAL POLLUTANTS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESTROGEN RECEPTOR MODULATORS; ESTROGENS; LIVER; MALE; PROTEINS; VITELLOGENINS;

ANIMALIA; CYPRINUS CARPIO;

EID: 0032839421     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/50.2.206     Document Type: Article

References (34)

1. Bongers, A. B. J., in't Veld, E. P. C., Abo-Hashema, K., Bremmer, I. M., Eding, E. H., Komen, J., and Richter, C. J. J. (1994). Androgenesis in common carp (Cyprinus carpio L.) using UV radiation in a synthetic ovarian fluid and heat shocks. Aquaculture 122, 119-132.
2. Bradford, M. M. (1976). A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
3. Bulger, W. H., Muccitelli, R. M., and Kupfer, D. (1978). Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites : role of hepatic monooxygenase in methoxychlor activation. Biochem. Pharmacol. 27, 2417-2423.
4. Burke, M. D., and Mayer, R. T. (1974). Ethoxyresorufin: Direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Metab. Dispos. 2, 583-588.
5. Clement, J. G., and Okey, A. B. (1972). Estrogenic and antiestrogenic effects of DDT administered in the diet of immature female rats. Can. J. Physiol. Pharmacol. 50, 971-975.
6. Dehal, S. S., and Kupfer, D. (1994). Metabolism of the proestrogenic pesticide methoxychlor by hepatic P450 monooxygenases in rats and humans. Dual pathways involving novel ortho ring-hydroxylation by CYP2B. Drug Metab. Dispos. 22, 937-946.
7. Denizot, F., and Lang, R. (1986). Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J. Immunol. Methods 89, 271-277.
8. Folmar, L. C., Denslow, N. D., Rao, V., Chow, M., Crain, D. A., Enblom, J., Marcino, J., and Guillette, L. J., Jr. (1996). Vitellogenin induction and reduced serum testosterone concentrations in feral male carp (Cyprinus carpio) captured near a major metropolitan sewage treatment plant. Environ. Health Perspect. 104, 1096-1101.
9. Gaido, K. W., Leonard, L. S., Lovell, S., Gould, J. C., Babai, D., Portier, C. J., and McDonnell, D. P. (1997). Evaluation of chemicals with endocrine modulating activity in a yeast-based steroid hormone receptor gene tran-scription assay. Toxicol. Appl. Pharmacol. 143, 205-212.
10. Gimeno, S. (1997). The estrogenicity of alkylphenols in the aquatic environment. An approach for risk assessment using various life-stages of all male carp populations, Ph.D. thesis, Utrecht University, Utrecht, the Netherlands.
11. Gimeno, S., Gerritsen, A., Bowmer, T., and Komen, H. (1996). Feminization of male carp. Nature 384, 221-222.
12. Golden, R. J., Noller, K. L., Titus-Ernstoff, L., Kaufman, R. H., Mittendorf, R., Stillman, R., and Reese, E. A. (1998). Environmental endocrine modulators and human health: An assessment of the biological evidence. Crit. Rev. Toxicol. 28, 109-227.
13. Jobling, S., and Sumpter, J. P. (1993). Detergent components in sewage effluent are weakly estrogenic to fish - an in-vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat. Toxicol. 27, 361-372.
14. Komen, J., Bongers, A. B. J., Richter, C. J. J., van Muiswinkel, W. B., and Huisman, E. A. (1991). Gynogenesis in common carp (Cyprinus carpio L.): II. The production of homozygous gynogenetic clones and F1 hybrids. Aquaculture 92, 127-142.
15. Krishnan, A. V., Stathis, P., Permuth, S. F., Tokes, L., and Feldman, D. (1993). Bisphenol-A: An estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology 132, 2279-2286.
16. Kupfer, D. (1975). Effects of pesticides and related compounds on steroid metabolism and function. CRC Crit. Rev. Toxicol. 4, 83-124.
17. Legler, J., van den Brink, C. E., Brouwer, A., Murk, A. J., van der Saag, P. T., Vethaak, A. D., and van der Burg, B. (1999). Development of a stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line. Toxicol. Sci. 48, 55-66.
18. McLachlan, J. (1997). Synergistic effect of environmental estrogen: report withdrawn. Science 277, 462-463.
19. Nichols, K. E., Snyder, S., Miles-Richardson, S., Pierens, S., and Giesy, J. P. (1999). Effects of nonylphenol ethoxylate (NPEO) on reproductive output of the fathead minnow (Pimephales promelas) and indicators of estrogenicity. Environ. Toxicol. Chem. (in press).
20. Nimrod, A. C., and Benson, W. H. (1996). Estrogenic responses to xenobiotics in channel catfish (Ictalurus punctatus). Mar. Environ. Res. 42, 155-160.
21. Nimrod, A. C., and Benson, W. H. (1997), Xenobiotic interaction with and alteration of channel catfish estrogen receptor. Toxicol. Appl. Pharmacol. 147, 381-390.
22. Pakdel, F., Le Gac, F., Le Goff, P., and Valotaire, Y. (1990). Full length sequence and in-vitro expression of rainbow trout estrogen receptor cDNA. Mol. Cell. Endocrinol. 71, 115-204.
23. Pelissero, C., Flouriot, G., Foucher, J. L., Bennetau, B., Dunogues, J., Le Gac, F., and Sumpter, J. P. (1993). Vitellogenin synthesis in cultured hepatocytes; an in-vitro test for the estrogenic potency of chemicals. J. Steroid Biochem. Mol. Biol. 44, 263-272.
24. Petit, F., Le Goff, P., Cravedi, J. P., Valotaire, Y., and Pakdel, F. (1997). Two complementary bioassays for screening the estrogenic potency of xenobiotics: Recombinant yeast for trout estrogen receptor and trout hepatocyte cultures. J. Mol. Endocrinol. 19, 321-335.
25. Ramamoorthy, K., Wang, F., Chen, I. C., Norris, J. D., McDonnell, D. P., Leonard, L. S., Gaido, K. W., Bocchinfuso, W. P., Korach, K. S., and Safe, S. (1997). Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: No apparent synergism. Endocrinology 138, 1520-1527.
26. Routledge, E. J., Sheahan, D., Desbrow, C., Brighty, G. C., Waldock, M., and Sumpter, J. P. (1998). Identification of estrogenic chemicals in STW effluent: II. In vivo responses in trout and roach. Environ. Sci. Technol. 32, 1559-1565.
27. Schlenk, D., Stresser, D. M., McCants, J. C., Nimrod, A. C., and Benson, W. H. (1997). Influence of β-naphthoflavone and methoxychlor pretreatment on the biotransformation and estrogenic activity of methoxychlor in channel catfish (Ictalurus punctatus). Toxicol. Appl. Pharmacol. 145, 349-356.
28. Smeets, J. M. W., Rankouhi, T., Nichols, K. M., Komen, H., Kaminsky, N. E., Giesy, J. P., and van den Berg, M. (1999). In vitro vitellogenin production by carp (Cyprinus carpio) hepatocytes as a screening method for determining (anti)estrogenic activity of xenobiotics. Toxicol. Appl. Pharmacol. 157, 68-76.
29. Soto, A. M., Chung, K. L., and Sonnenschein, C. (1994). The pesticides endosulfan, toxaphene, and dieldrin have estrogenic effects on human estrogen-sensitive cells. Environ. Health Perspect. 102, 380-383.
30. Soto, A. M., Sonnenschein, C., Chung, K. L., Fernandes. M. F., Olea, N., and Serrano, F. O. (1995). The E-SCREEN assay as a tool to identify estrogens: An update on estrogenic environmental pollutants. Environ. Health Perspect. 103, 113-122.
31. Sumpter, J. P., and Jobling, S. (1995). Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment. Environ. Health Perspect. 7, 173-178.
32. White, R., Jobling, S., Hoare, S. A., Sumpter, J. P., and Parker, M. G. (1994). Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology 135, 175-182.
33. Yamamoto, J. T., Donohue, R. M., Fry, D. M., Golub, M. S., and Donald, J. M. (1996). Environmental estrogens: Implications for reproduction in wildlife. In Noninfectious Diseases of Wildlife (A. Fairbrother, L. N. Locke, and G. L. Hoff, Eds.), pp. 31-51. Iowa State University Press, Ames, IA.
34. Zacharewski, T. (1997). In vitro bioassays for assessing estrogenic substances. Environ. Sci. Technol. 31, 613-623.