Methylprednisolone differentially regulates IL-10 and tumour necrosis factor (TNF) production during murine endotoxaemia

Clinical and Experimental Immunology

Volumn 106, Issue 1, 1996, Pages 91-96

  Marchant, A ^a   Amraoui, Z ^a   Gueydan, C ^a   Bruyns, C ^a   Le Moine, O ^a   Vandenabeele, P ^b   Fiers, W ^b   Buurman, W A ^c   Goldman, M ^a,d  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d ERASME HOSPITAL   (Belgium)

Author keywords

Glucocorticoids; IL 10; Lipopolysaccharide; Macrophage; Tumour necrosis factor

Indexed keywords

INTERLEUKIN 10; LIPOPOLYSACCHARIDE; METHYLPREDNISOLONE; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; ENDOTOXEMIA; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0029739991     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1996.d01-799.x     Document Type: Article

References (42)

1. Cupps TR, Fauci AS. Cortieosteroid-mediated immunoregulalion in man. Immunolgical Rev 1982; 65:133 55.
2. Beutler B, Krochin N, Milsark IW, Lucdkc C, Cerami A. Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science 1986; 232:977 80.
3. Fantuzzi G, Demitri MT, Ghezzi P. Differential effect of glucocorticoids on tumor necross factor production in mice: up-regulation by early pretreatment with dexamethasone. Clin Exp Immunol 1994; 96:166 9.
4. Gonzalez JC, Johnson DC, Morrison DC, Freudenherg MA, Galanos C, Silverstein R. Endogenous and exogenous glucocorticoids have different roles in modulating endotoxin lethality in D-galactosamine-sensitized mice. Infect Immun 1993; 61:970 4.
5. Zuckerman SH, Shellas J, Butler LD. Differential regulation of lipopolysaccharide-induced interleukin 1 and tumor necrosis factor synthesis: effects of endogenous and exogenous glucocorticoids and the role of the pituitary-adrenal axis. Eur J Immunol 1989; 19: 301 5.
6. Fantuzzi G, Di Santo E, Sacco S, Benigni F, Ghezzi P. Role of the hypothalamus pituitary adrenal axis in the regulation of TNF production in mice. J Immunol 1995; 155:3552 5.
7. Bertini R, Bianchi M, Ghezzi P. Adrenalectomy sensitizes mice to the lethal effects of interleukin-1 and tumor necrosis factor. J Exp Med 1988; 167:1708 12.
8. Hawes AS, Rock CS, Keogh CV, Lowry SF, Calvano SE. In vivo effects of the antiglucocorticoid RU 486 on glucocorticoid and cytokine responses to Escherichia coli endotoxin. Infect Immun 1992; 60:2641 7.
9. Moore KW, O'Garra A, De Waal Malefyt R, Vieira P, Mosmann TR. Interleukin-10. Annu Rev Immunol 1993; 11:165-90.
10. Gerard C, Bruyns C, Marchant A et al. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med 1993; 177:547 50.
11. Howard M, Muchamuel T, Andrade S, Menon S. Interleukin 10 protects mice from lethal endotoxemia. J Exp Med 1993; 177:1205 8.
12. Derkx B, Marchant A, Goldman M, Bijlmer R, van Deventer S. High levels of interleukin-10 during the initial phase of fulminant meningococcal septic shock. J Infect Dis 1995; 171:229-32.
13. Marchant A, Deviere J, Byl B, De Groote D, Vincent JL, Goldman M. Interleukin-10 production during septicaemia. Lancet 1994; 343:707-8.
14. Marchant A, Alegre ML, Hakim A et al. Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock. J Clin Immunol 1995; 15:265-72.
15. Peyron F, Burdin N, Ringwald P, Vuillez JP, Rousset F, Banchereau J. High levels of circulating IL-10 in human malaria. Clin Exp Immunol 1994; 95:300 3.
16. Katsikis PD, Chu CQ, Brennun FM, Maini RN, Feldmann M. Immunoregulatory role of interleukin 10 in rheumatoid arthritis. J Exp Med 1994; 179:1517 27.
17. Durez P, Abramowicz D, Gerard C et al. In vivo induction of interleukin 10 by anti-CD3 monoclonal antibody or bacterial lipopolysaccharide: differential modulation by cyclosporin A. J Exp Med 1993; 177:551-5.
18. Marchant A, Bruyns C, Vandenabeele P et al. Interleukin-10 controls Interferon-γ and tumor necrosis factor production during experimental endotoxemia. Eur J Immunol 1994; 24:1167 71.
19. van der Poll T, Marchant A, Buurman WA et al. Endogenous interleukin-10 protects mice from death during septic peritonitis. J Immunol 1995; 155:5397-401.
20. Bourrie B, Bouaboula M, Benoit JM, Derocq JM, Esclangon M, Le Fur G, Cassellas P. Enhancement of endotoxin-induced interleukin-10 production by SP 3174 A, a sigma ligand. Eur J Immunol 1995; 25:2882 7.
21. De Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174:1209 20.
22. Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O'Garra A. IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991; 147:3815-22.
23. van der Poll T, Jansen J, Levi M, ten Cate H, ten Cate JW, van Deventer S. Regulation of interleukin 10 release by tumor necrosis factor in humans and chimpanzees. J Exp Med 1994; 180:1985 8.
24. Wanidworanun C, Strober W. Predominant role of tumor necrosis factor-alpha in human monocyte IL-10 synthesis. J Immunol 1993; 151:6853 61.
25. Goldman M, Marchant A, Schandené L. Endogenous interleukin-10 in inflammatory disorders: regulatory roles and pharmacological modulation. Proc NY Acad Sci 1996; in press.
26. Platzer C, Meisel C, Vogt K, Platzer M, Volk HD, Up-regulation of monocytic IL-10 by tumor necrosis factor-α and cAMP elevating drugs. Int Immunol 1995; 7:517 23.
27. Strassmann G, Patil Koota V, Finkelman F, Fong M, Kambayashi TJ. Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2. J Exp Med 1994; 180:2365-70.
28. Sheehan KCF, Ruddle NH, Schreiber RD. Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors. J Immunol 1989, 142:3884 93.
29. Espevik T, Nissen-Meyer J. A highly sensitive cell line. WEHI 164 clone 13, for measuring cytotoxic factor tumor necrosis factor from human monocytes. J Immunol Methods 1986; 95:99 105.
30. Mengozzi M, Fantuzzi G, Faggioni R et al. Chlorpromazine specifically inhibits peripheral and brain TNF production, and upregulates IL-10 production, in mice. Immunology 1994; 82:207-10.
31. Fouqueray B, Boutard V, Philippe C et al. Mesangial cell-derived interleukin-10 modulates mesangial cell response to lipopolysaccharide. Am J Pathol 1995; 147:176 82.
32. Barsig J, Küsters S, Vogt K, Tiegs G, Wendel A. Lipopolysaccharide-induced interleukin-10 in mice: role of endogenous tumor necrosis factor-α. Eur J Immunol 1995; 25:2888 93.
33. Han J. Thompson P, Beutler B, Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin tumor necrosis factor synthesis at separate points in the signalling pathway. J Exp Med 1990; 172:391 4.
34. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 1995; 270:283 6.
35. Scheinman RI, Gualberto A, Jewell CM, Cidlowski JA, Baldwin AS. Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. Mol Cell Biol 1995; 15:943 53.
36. Shakhov AN, Collart MA, Vassalli P, Nedospasov SA. Jongeneel CV. Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages. J Exp Med 1990; 171:35 47.
37. Auphan N, Di Donato JA, Rosette C, Helmberg A, Karin M. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis. Science 1995; 270:286 90.
38. Tebo JM, Chaoqun W, Ohmori Y, Hamilton TA. Murine inhibitory protein-kappa B alpha negatively regulates kappa B-dependent transcription in lipopolysaccharide-stimulated RAW 264.7 macrophages. J Immunol 1944; 153:4713 20.
39. Kim JM, Brannan CI, Copeland NG, Jenkins NA, Khan TA, Moore KW. Structure of the mouse IL-10 gene and chromozomal localization of the mouse and human genes. J. Immunol 1992; 148:3618 23.
40. De Waal Malefyt R, Yssel H, de Vries JE. Direct effects of IL-10 on subsets of human CD4 T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation. J Immunol 1993; 150:4754 65.
41. Joyce DA, Gibbons DP, Green P, Steer JH, feldmann M, Brennan FM. Two inhibitors of pro-inflammatory cytokine release, interleukin-10 and interleukin-4. have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes. Eur J Immunol 1994; 24:2699 705.
42. Leeuwenberg JFM, Jeunhome TMAA, Buurman WA. Slow release of soluble TNF receptors by monocytes in vitro. J Immunol 1994; 152:4036 43.