Glutamate transport asymmetry and metabolism in the functioning kidney

American Journal of Physiology - Endocrinology and Metabolism

Volumn 277, Issue 3 40-3, 1999, Pages

  Schuldt, Scott ^a   Carter, Patsy ^a   Welbourne, Tomas ^a  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

5 oxoproline; Ammonium; D aspartate; Excitatory amino acid transporter carrier 1; GLT1 glutamate transporter; Glutamate isomers; Glutamine; System X(AG) subtypes

Indexed keywords

CARRIER PROTEIN; EXCITATORY AMINO ACID RECEPTOR; GLUTAMIC ACID; PYROGLUTAMIC ACID;

AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ARTICLE; CELL METABOLISM; CELL PH; CELL SURFACE; GLOMERULUS FILTRATION RATE; KIDNEY PERFUSION; KIDNEY TUBULE ABSORPTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0032837097     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1999.277.3.e439     Document Type: Article

References (33)

1. Arriza, J., W. Fairman, J. Wadicke, G. Murdock, M. Kavanaugh, and S. Amara. Functional comparison of three glutamate transporter subtypes cloned from human motor cortex. J. Neurosci. 14: 5539-5569, 1994.
2. Bernt, E., and H. U. Bergmeyer. L-Glutamate: UV-assay with glutamate dehydrogenase and NAD. In: Methods of Enzymatic Analysis, edited by H. U. Bergmeyer. New York: Academic, 1974, vol. 4, p. 1704.
3. Burch, H., S. Choi, W. McCarthy, P. Wong, and O. Lowry. The localization of glutamine synthetase within the rat and rabbit nephron. Biochem. Biophys. Res. Comm. 82: 498-505, 1978.
4. Carter, P., and T. C. Welbourne. Glutamate transport asymmetry in renal glutamine metabolism. Am. J. Physiol. 274 (Endocrinol. Metab. 37): E877-E884, 1998.
5. Ceballos-Picot, I., V. Witko-Sarsat, M. Merad-Boudia, A. T. Nguyen, M. Thevenin, M. C. Jaudon, J. Zingraff, C. Verger, P. Jungersn, and B. Descamps-Latscha. Glutathione antioxidant system as a marker of oxidative stress in chronic renal failure. Free Rad. Biol. Med. 24: 845-853, 1996.
6. Chen, X.-Z., C. Shayakul, U. V. Berger, and M. A. Hediger. Characterization of the rat Na+ dicarboxylate cotransporter. J. Biol. Chem. 273: 20972-20981, 1998.
7. Damian, A., and R. F. Pitts. Rates of glutaminase 1 and glutamine synthetase reactions in rat kidney in vivo. Am. J. Physiol. 218: 1248-1255, 1970.
8. Gazzola, G., V. Dall'Asta, O. Bussolati, M. Makouwski, and H. Christensen. A stereoselective anomaly in dicarboxylic amino acid transport. J. Biol. Chem. 256: 6054-6059, 1981.
9. Johnson, D. W., B. K. Brew, P. Poronnik, D. I. Cook, M. J. Field, A. Z. Györy, and C. A. Pollock. Insulin-like growth factor I stimulates apical sodium/hydrogen exchange in human proximal tubule cells. Am. J. Physiol. 272 (Renal Physiol. 41): F484-F490, 1997.
10. Kanai, Y., and M. A. Hediger. Primary structure and functional characterization of a high-affinity glutamate transporter. Nature 360: 467-471, 1992.
11. Kanai, Y., S. Nussberger, M. F. Romero, W. F. Boron, S. C. Hebert, and M. A. Hediger. Electrogenic properties of the epithelial and neural high-affinity glutamate transporter. J. Biol. Chem. 270: 16561-16568, 1995.
12. Kitos, P., and C. Waymouth. The metabolism of L-glutamate and L-5-carboxypyrrolidone by mouse cells under conditions of defined nutrition. J. Cell. Physiol. 67: 383-398, 1967.
13. Lerner, J. Acidic amino acid transport in animal cells and tissues. Comp. Biochem. Physiol. 87B: 443-457, 1987.
14. Maack, T. Physiological evaluation of the isolated perfused rat kidney. Am. J. Physiol. 238 (Renal Fluid Electrolyte Physiol. 7): F71-F78, 1980.
15. Matthews, J. C., M. J. Beveridge, M. S. Malandro, J. D. Rothstein, M. Campbell-Thompson, J. W. Verlander, M. S. Kilberg, and D. A. Novak. Activity and protein localization of multiple glutamate transporters in gestation day 14 vs. day 20 rat placenta. Am. J. Physiol. 274 (Cell Physiol. 43): C603-C614, 1998.
16. Meister, A., and M. Bukenberger. Enzymatic conversion of D-glutamatic acid to D-pyrrolidone carboxylic acid by mammalian tissues. Nature 194: 557-559, 1962.
17. Mu, X., and T. Welbourne. Response of LLC-PK1-F+ cells to metabolic acidosis. Am. J. Physiol. 270 (Cell Physiol. 39): C920-C925, 1996.
18. Nissim, I., S. Wehrill, B. States, and M. Yudkoff. Analysis and physiological implications of renal 2-oxoglutaramate metabolism. Biochem. J. 277: 33-38, 1991.
19. 14C in tissues of tumor-bearing rats. Cancer Res. 18: 385-393, 1958.
20. Peghini, P., J. Janzen, and W. Stoffel. Glutamate transporter EAAC1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration. EMBO J. 16: 3822-3832, 1997.
21. Ratner, S. Conversion of D-glutamic acid to pyrrolidone carboxyliic acid by the rat. J. Biol Chem. 152: 559-564, 1944.
22. Schafer, J., and J. Williams. Transport of metabolic substrates by the proximal nephron. Annu. Rev. Physiol. 47: 103-125, 1985.
23. Schneider, H., K.-H. Mohlen, J.-C. Challier, and J. Dancis. Transfer of glutamic acid across the human placenta perfused in vitro. Br. J. Obst. Gynaecol. 86: 299-306, 1979.
24. Sekura, R., P. Van der Werf, and A. Meister. Mechanism and significance of the mammalian pathway for elimination of D-glutamate; inhibition of glutathione synthesis by D-glutamate. Biochem. Biophys. Res. Commun. 71: 11-18, 1976.
25. Shayakul, C., Y. Kanai, W.-S. Lee, D. Brown, J. D. Rothstein, and M. A. Hediger. Localization of the high-affinity glutamate transporter EAAC1 in the rat kidney. Am. J. Physiol. 273 (Renal Physiol. 42): F1023-F1029, 1997.
26. Silbernagl, S. Kinetics and localization of tubular reabsorption of acidic amino acids. A micropuncture and free flow micropuncture study in the rat kidney. Pflügers Arch. 396: 218-224, 1983.
27. Steele, A., and M. A. Hediger. The molecular physiology of sodium and proton-coupled solute transporters. News Physiol. Sci. 13: 123-131, 1998.
28. Tannen, R. L. Renal ammonia production and excretion. In: Handbook of Renal Physiology. Bethesda, MD: Am. Physiol Soc., 1992, sect. 8, vol I, chapt. 23, p. 1017-1059.
29. Ullrich, K. J., H. Fasold, G. Rumrich, and S. Kloss. Secretion and contralateral uptake of dicarboxylic acids in the proximal convolution of rat kidney. Pflügers Arch. 400: 241-249, 1984.
30. Van der Werf, P., and A. Meister. The metabolic formation and utilization of 5-L-oxoproline (L-pyroglutamate, L-pyrolidone carboxylate). Adv. Enzymol. 43: 519-566, 1975.
31. Welbourne, T., and M. Cronin. Growth hormone accelerates tubular acid secretion. Am. J. Physiol. 260 (Regulatory Integrative Comp. Physiol. 29): R1036-R1042, 1991.
32. Welbourne, T., and P. Dass. Gamma glutamyltransferase contribution to renal ammoniagenesis in vivo. Pflügers Arch. 411: 573-578, 1988.
33. Welbourne, T., and J. Fuseler. Growth hormone-enhanced acid production and glutamate and glutamine utilization in LLC-PK1-F+ cells. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E874-E879, 1993.