Increased expression of IL-10 and IL-12 (p40) mRNA in Helicobacter pylori infected gastric mucosa: Relation to bacterial cag status and peptic ulceration

Journal of Clinical Pathology

Volumn 52, Issue 9, 1999, Pages 658-664

  Hida, N ^a   Shimoyama Jr , T ^a   Neville, P ^b   Dixon, M F ^b   Axon, A T R ^b   Shimoyama Sr , T ^c   Crabtree, J E ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^b LEEDS GENERAL INFIRMARY   (United Kingdom)

^c HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Cag pathogenicity island; H pylori; IL 10; IL 12; Peptic ulcer

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 10; INTERLEUKIN 12; MESSENGER RNA; PROTEIN P40;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CYTOTOXIC ASSOCIATED GENE A; DUODENUM ULCER; DYSPEPSIA; ENDOSCOPY; GENE EXPRESSION; HELICOBACTER PYLORI; HISTOPATHOLOGY; HUMAN; MAJOR CLINICAL STUDY; MESSENGER RNA SYNTHESIS; PEPTIC ULCER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH MUCOSA;

HELICOBACTER PYLORI;

EID: 0032835306     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.52.9.658     Document Type: Article

References (55)

1. Crabtree JE. Role of cytokines in pathogenesis of Helicobacter pylori-induced mucosal damage. Dig Dis Sci 1998;43:46-55S.
2. Mohammadi M, Czinn S, Redline R, et al. Helicobacter-specific cell-mediated responses display a predominant Th 1 phenotype and promote a delayed-type hypersensitivity response in the stomach of mice. J Immunol 1996;156:4729-38.
3. Mohammadi M, Nedrud J, Redline R, et al. Murine CD4 T-cell response to Helicobacter infection: TH1 cells enhance gastritis and TH2 cells reduce bacterial load. Gastroenterology 1997;113:1848-57.
4. Del Prete G. The concept of type-1 and type-2 helper T cells anal their cytokines in humans. Int Rev Immunol 1998;16:427-55.
5. Paul WE, Seder RA. Lymphocyte responses and cytokines. Cell 1994;76:241-51.
6. Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995;13:251-76.
7. D'Andrea A, Rengaraju M, Valiante NM, et al. Production of natural killer cell stimulating factor (NKSF/IL-12) by peripheral blood mononuclear cells. J Exp Med 1992;176:1387-98.
8. Fiorentino DF, Bond MW, Mossmann TR. Two types of mouse T helper cells. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989;170:2081-95.
9. Moore KW, O'Garra A, De Waal Malefyt R, et al. Interleukin-10. Annu Rev Immunol 1993;11:165-90.
10. D'Andrea A, Aste-Amezaga M, Valiante NM, et al. Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993;178:1041-8.
11. De Vries JE. Immunosuppressive and anti-inflammatory properties of interleukin 10. Ann Med 1995;27:537-41.
12. D'Elios MM, Manghetti M, Almerigogna F, et al. Different cytokine profile and antigen-specificity repertoire in Helicobacter pylori-specific T cell clones from the antrum of chronic gastritis patients with or without peptic ulcer. Eur J Immunol 1997;27:1751-5.
13. D'Elios MM, Manghetti M, De Carli M, et al. T helper 1 effector specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease. J Immunol 1997;158:962-7.
14. Karltunen R, Kattunen T, Ekre HPT, et al. Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis. Gut 1995;36:341-5.
15. Bamford KB, Fan X, Crowe SE, et al. Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell I phenotype. Gastroenterology 1998;114:482-92.
16. Peek RM, Miller GG, Tham KT, et al. Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains. Lab Invest 1995;71:760-70.
17. Crabtree JE, Farmery SM, Lindley IJD, et al. CagA/ cytotoxic strains of Helicobacter pylori and interleukin-8 in gastric epithelial cells. J Clin Pathol 1994;47:945-50.
18. Crabtree JE, Covacci A, Farmery SM, et al. Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype. J Clin Pathol 1995;48:967-9.
19. Shimoyama T, Everett SM, Dixon MF, et al. Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis. J Clin Pathol 1998;51:765-70.
20. Yamaoka Y, Kita M, Kodama T, et al. Chemokines in the gastric mucosa in Helicobacter pylori infection. Gut 1998;42:609-17.
21. Covacci A, Censini S, Bugnoli M, et al. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci USA 1993;90:5791-5.
22. Kuipers EJ, Perez-Perez GI, Meuwissen SG, et al. Helicobacter pylori and atrophic gastritis: importance of the cagA status. J Natl Cancer Inst 1995;87:1777-80.
23. Blaser MJ, Perez-Perez GI, Kleanrhous H, et al. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 1995;55:2111-15.
24. Rodger K, Wyatt JI, Heatley RV. Gastric mucosal secretion of interleukin-10: relations to histopathology, Helicobacter pylori status, and tumour necrosis factor-α secretion. Gut 1997;40:739-44.
25. Yamaoka Y, Kita M, Kodama T, et al. Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa. Gastroenterology 1996;110:1744-52.
26. Karttunen RA, Karttunen TJ, Yousfi MM, et al. Expression of mRNA for interferon-gamma, interleukin-10, and interleukin-12 (p40) in normal gastric mucosa and in mucosa infected with Helicobacter pylori. Scand J Gastroenterol 1997;32:22-7.
27. Hacberle HA, Kubin M, Bamford KB, et al. Differential expression of interleukin-12 (IL-12) and IL-10 by live and killed Helicobacter pylori in vitro and association of IL-12 production with gamma interferon-producing T cells in human gastric mucosa. Infect Immun 1997;65:4229-35.
28. Yamaoka Y, Kita M, Kodama T, et al. Induction of various cytokines and development of severe mucosal inflammation by cagA gene positive Helicobacter pylori strains. Gut 1997;41:442-51.
29. Dixon MF, Genta RM, Yardley JH, et al. Classification and grading of gastritis. Am J Surg Pathol 1996;20:1161-81.
30. Warburton VJ, Everett S, Mapstone NP, et al. Clinical and histological associations of cagA and vacA genotypes in Helicobacter pylori gastritis. J Clin Pathol 1998;51:55-61.
31. McFarlane DE, Dahle CE. Isolating RNA from whole blood the dawn of RNA-based diagnosis? Nature 1993;362;186-8.
32. Klava A, Windsor ACJ, Farmery SM, et al. Interleukin-10, a role in development of postoperative immunosuppression. Arch Surg 1997;132:425-9.
33. Farmery SM, Crabtree JE. Host response to H. pylori: molecular analysis of cytokine gene expression. In: Clayton CL, Mobley HL, eds. Helicobacter pylori protocol. New Jersey: Humana Press, 1997:225-34.
34. Manetti R, Parronchi P, Giudízi MG, et al. Natural killer cell stimulatory factor (NKSF/IL-12) induces Th1-type specific immune responses and inhibits the development of IL-4 producing Th cells. J Exp Med 1993;177:1199-204.
35. Manetti R, Gerosa F, Giudizi MG, et al. Interleukin-12 induces stable priming for interferon-gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones. J Exp Med 1991;179:1273-83.
36. Trinchieri G. Proinflammatory and immunoregulatory functions of interleukin-12. Int Rev Immunol 1998;16:365-96.
37. Magram J, Connaughton SE, Warrier RR, et al. IL-12-deficient mice are defective in IFN-gamma production and type I cytokine responses. Immunity 1996;4:471-81.
38. Crabtree JE, Taylor JD, Wyatt JI, et al. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration and gastric pathology. Lancet 1991;338:332-5.
39. Weel JFL, van der Hulst RWM, Gerrits Y, et al. The interrelationship between cytotoxin-associated gene A, vacuolating cytotoxin and Helicobacter pylori-related diseases. J Infect Dis 1996;173:1171-5.
40. Webb PM, Crabtree JE, Forman D, et al. Gastric cancer, cytotoxin-associated gene-A positive Helicobacter pylori and serum pepsinogens: an international study. Gastroenterology 1999;116:269-76.
41. Pan ZJ, van der Hulst RWM, Feller M, et al. Equally high prevalence of infection with cagA-positive Helicobacter pylori in Chinese patients with peptic ulcer disease and chronic gastritis-associated dyspesia. J Clin Microbiol 1997;35:1344-7.
42. Valnes K, Huitfeldt HS, Brandtzaeg P. Relation between T cell number and epithelial HLA class II expression quantified by image analysis in normal and inflamed human gastric mucosa. Gut 1990;31:647-52.
43. Mullin JM, Snock KV. Effect of tumor necrosis factor on epithelial tight junctions and transepithelial permeability. Cancer Res 1990;50:2172-6.
44. Madara JL, Stafford J. Interferon-gamma directly affects barrier function of cultured intestinal monolayers. J Clin Invest 1989;83:724-7.
45. El-Omar EM, Penman ID, Ardill JES, et al. Helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease. Gastroenterology 1995;109:681-91.
46. Lehmann FS, Golodner EH, Wang J, et al. Mononuclear cells and cytokines stimulate gastrin release from canine antral cells in primary culture. Am J Physiol 1996;270:G783-8.
47. Groux H, O'Garra A, Bigler M, et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997;389:737-41.
48. Niessner M, Volk BA. Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clin Exp Immunol 1995;101:428-35.
49. Monteleone G, Biancone L, Marasco R, et al. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 1997;112:1169-78.
50. Schreiber S, Heinig T, Thiele H-G, et al. Immunoregulatory role of Interleukin 10 in patients with inflammatory bowel disease. Gastroenterology 1995;108:1434-44.
51. Berg DJ, Lynch NA, Lynch RG, et al. Rapid development of severe hyperplastic gastritis with gastric epithelial dedifferentiation in Helicobacter felis-infected IL-10-/-mice. Am J Pathol 1998;152:1377-86.
52. Crabtree JE, Peichl P, Wyatt JI, et al. Gastric interleukin-8 and IgA IL-8 autoantibodies in Helicobacter pylori infection. Scand J Immunol 1993;37:65-70.
53. Bonner JC, Brody AR. Cytokine-binding proteins in the lung. Am J Physiol 1995;268:L869-78.
54. Kasama T, Strieter RM, Lukacs NW, et al. Regulation of neutrophil-derived chemokine expression by IL-10. J Immunol 1994;152:3559-69.
55. Meyaard L, Hovenkamp E, Otto SA, et al. IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses. J Immunol 1996;156:2776-82.