Synthesis and nuclease stability of dinucleotides containing an anti conformationally constrained acyclic thymidine

Nucleosides and Nucleotides

Volumn 18, Issue 9, 1999, Pages 2031-2042

  Hsu, Ling Yih ^a   Yang, Kuo Tsao ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

DINUCLEOTIDE; NUCLEASE; THYMIDINE;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; DRUG CONFORMATION; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ANALYSIS; ENZYME STABILITY; STRUCTURE ANALYSIS;

EID: 0032834812     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319908044862     Document Type: Article

References (16)

1. Review article: Beaucage, S. L.; Iyer, R. P. Tetrahedron 1993, 49, 6123. Uhlmann, E.; Peyman, A. Chem Rev. 1990, 90, 543, and references cited.
2. Review article: Beaucage, S. L.; Iyer, R. P. Tetrahedron 1993, 49, 6123. Uhlmann, E.; Peyman, A. Chem Rev. 1990, 90, 543, and references cited.
3. Cohen, J. S., Oligonucleotides: Antisense Inhibitors of Gene Expression, The Macmillian Press LTD, London. 1989.
4. Usman, N; Jubt, C. D.; and Ogilve, K. K., Tetrahedron Lett., 1988, 29, 4831.
5. Schneider, K. C.; and Benner, S. A., J. Am. Chem. Soc., 1990, 112, 453.
6. Augustyns, K; Aerschot, A. V.; Schepdael, A. V.; Urbanke, C.; and Herdewijn P., Nucleic Acids Res., 1991, 19, 2587.
7. Marquez, V. E.; Siddiqui, M. A.; Ezzitouni, A.; Russ, P.; Wang, J.; Wagner, R. W. and Matteucci, M. D., J. Med. Chem., 1996, 39, 3739.
8. Marquez, V. E., New Conformationally Restricted Nucleosides, XIII International Round Table, "Nucleosides, Nucleotides and their Biological Applications", Montpellier, France, 1998.
9. Wengel J.; Koshkin, A. A.; Singh, S. K.; Nielsen, P.; Rajwanshi, V. K.; Kumar, R.; and Meldgaard, M., LNA (Locked Nucleic Acids), XIII International Round Table, "Nucleosides, Nucleotides and their Biological Applications", Montpellier, France, 1998.
10. Hsu, L. Y.; Wise, D. S.; Drach, J. C. and Townsend, L. B., Chin. Pharm. J., 1991, 43, 275.
11. Hsu, L. Y.; Wise, D. S.; Kucera, L. S.; Drach, J. C. and Townsend, L. B., J. Org. Chem., 1992, 57, 3354.
12. Hsu, L. Y.; Wise, D. S.; Shannon, W. M., Drach, J. C., and Townsend, L. B, Nucleosides and Nucleotides, 1994, 13, 563.
13. Hsu, L. Y.; Wise, D. S.; Drach, J. C., and Townsend, L. B., Nucleosides and Nucleotides, 1996, 15, 1481.
14. Hsu, L. Y.; Chang, Y. M.; Lin, C. H. and Drach, J. C., Nucleosides and Nucleotides, 1996, 15, 1835.
15. Hsu, L. Y. and Lin, C. H. Heterocycles, 1996, 43, 2687.
16. Hsu, L. Y. and Kang, Y. F., and Drach, J. C., Heterocycles, 1998, 48, 2163.