The testis-specific expression pattern of the growth hormone/placental lactogen (GH/PL) gene cluster changes with malignancy

Human Pathology

Volumn 30, Issue 10, 1999, Pages 1201-1206

  Berger, Peter ^a   Untergasser, Gerold ^b   Hermann, Martin ^b   Hittmair, Anton ^b   Madersbacher, Stephan ^b   Dirnhofer, Stephan ^b  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b NONE

Author keywords

Gene cluster expression; Human growth hormone; Testicular cancer

Indexed keywords

COMPLEMENTARY DNA; GROWTH HORMONE; PLACENTA LACTOGEN;

ADULT; ARTICLE; CANCER CELL; CHORIOCARCINOMA; CLINICAL ARTICLE; GENE CLUSTER; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALE; MALE GENITAL TRACT CANCER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TESTIS CANCER; TISSUE SPECIFICITY;

EID: 0032834750     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(99)90038-2     Document Type: Article

References (22)

1. Chen EY, Liao YC, Smith DH, et al: The human growth hormone locus: Nucleotide sequence, biology and evolution. Genomics 4:479-497, 1989
2. Wallis M: The expanding growth hormone/prolactin family. J Mol Endocrinol 9:185-188, 1992
3. Handwerger S: Clinical counterpoint: The physiology of placental lactogen in human pregnancy. Endocr Rev 12:329-336, 1991
4. Walker WH, Fitzpatrick SL, Barrera-Saldana HA, et al: The human placental lactogen genes: Structure, function, evolution and transcriptional regulation. Endocr Rev 12:316-328, 1991
5. Frantz AG, Rabkin MT, Friesen H: Human placental lactogen in choriocarcinoma of the male: Measurement by radioimmunoassay. J Clin Endocrinol Metab 25:1136-1139, 1965
6. Samaan N, Yen SCC, Friesen H, et al: Serum placental lactogen levels during pregnancy and in trophoblastic disease. J Clin Endocrinol Metab 26:1303-1308, 1966
7. Braunstein GD, Thompson R, Princier GL, et al: Trophoblastic proteins as tumor markers in nonseminomatous germ cell tumors. Cancer 57:1842-1845, 1986
8. Madersbacher S, Untergasser G, Gerth R, et al: Reassessment of the role of human placental lactogen in physiological non-pregnant and pathological conditions. Exp Clin Endocr Diab 106:61-67, 1998
9. MacLeod JN, Lee AK, Liebhaber SA, et al: Developmental control and alternative splicing of the placentally expressed transcripts from the human growth hormone gene cluster. J Biol Chem 267:14219-14226, 1992
10. Press AM, Cooke NE, Liebhaber SA: Complex alternative splicing partially inactivates the human chorionic somatomammotropin-like (hCS-L) gene. J Biol Chem 269:23220-23229, 1994
11. Nachtigal NW, Nickel BE, Cattini PA: Pituitary specific repression of placental members of the human growth hormone family. J Biol Chem 268:8473-8479, 1993
12. Untergasser G, Kranewitter W, Schwärzler P, et al: Organ-specific expression pattern of the human growth hormone/placental lactogen gene cluster in the testis. Mol Cell Endocrinol 130:53-60, 1997
13. Lytras A, Bock ME, Dodd JG, et al: Detection of placental growth hormone variant and chorionic somatotropin ribonucleic acid expression in human trophoblastic neoplasms by reverse transcriptase-polymerase chain reaction. Endocrinology 134:1461-1467, 1994
14. Chomczynski P, Sacchi N: Single step method of RNA isolation by acid-guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-157, 1987
15. Dirnhofer S, Berger C, Untergasser G, et al: Human β-actin retropseudogenes interfere with RT-PCR. Trends Genet 11:380-381, 1995
16. Madersbacher S, Kratzik C, Gerth R, et al: Human chorionic gonadotropin (hCG) and its free subunits in hydrocele fluids and neoplastic tissue of testicular cancer patients: Insights into the in vivo secretion pattern. Cancer Res 54:5096-5100, 1994
17. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbour Laboratory, 1989
18. Hennen G, Frankenne F, Closset J, et al: A human placental GH: Increasing levels during the second half of pregnancy with pituitary GH suppression revealed by monoclonal antibody radioimmunoassays. Int J Fertil 30:27-33, 1985
19. Liebhaber SA, Urbanek M, Ray J, et al: Characterization and histologic localization of human growth hormone-variant gene expression in the placenta. J Clin Invest 83:1985-1991, 1989
20. Andrews PA: Teratocarcinomas and human embryology: Pluripotent human EC cell lines. APMIS 106:158-168, 1998
21. MacLeod JN, Worsley I, Ray I, et al: Human growth hormone variant is a biologically active somatogen and lactogen. Endocrinology 128:1298-1302, 1991
22. de Jong B, Oosterhuis JW, Castedo SM, et al: Pathogenesis of adult testicular germ cell tumors: A cytogenetic model. Cancer Genet Cytogenet 48:143-167, 1990