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Volumn 43, Issue 3, 1999, Pages 201-207

Effect of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-ethyluracil on mitochondrial functions in HepG2 cells

Author keywords

D FEAU; Hepatitis B; Hepatotoxicity; Mitochondrial function

Indexed keywords

5 ETHYL 2' FLUOROURACIL ARABINOSIDE; LACTIC ACID; MITOCHONDRIAL DNA;

EID: 0032834676     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(99)00050-9     Document Type: Article
Times cited : (3)

References (22)
  • 2
    • 0024381627 scopus 로고
    • Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2′,3′-dideoxycytidine
    • Chen C.H., Cheng Y.C. Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2′,3′-dideoxycytidine. J. Biol. Chem. 264:1989;11934-11937.
    • (1989) J. Biol. Chem. , vol.264 , pp. 11934-11937
    • Chen, C.H.1    Cheng, Y.C.2
  • 3
    • 0026640705 scopus 로고
    • The role of cytoplasmic deoxycytidine kinase in the mitochondrial effects of the anti-human immunodeficiency virus compound 2′,3′-dideoxycytidine
    • Chen C.H., Cheng Y.C. The role of cytoplasmic deoxycytidine kinase in the mitochondrial effects of the anti-human immunodeficiency virus compound 2′,3′-dideoxycytidine. J. Biol. Chem. 267:1992;2856-2859.
    • (1992) J. Biol. Chem. , vol.267 , pp. 2856-2859
    • Chen, C.H.1    Cheng, Y.C.2
  • 5
    • 0028861575 scopus 로고
    • Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells
    • Cui L., Yoon S., Schinazi R.F., Sommadossi J.-P. Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells. J. Clin. Invest. 95:1995;555-563.
    • (1995) J. Clin. Invest. , vol.95 , pp. 555-563
    • Cui, L.1    Yoon, S.2    Schinazi, R.F.3    Sommadossi, J.-P.4
  • 6
    • 0030598407 scopus 로고    scopus 로고
    • Effect of beta-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells: Implication for predicting drug hepatotoxicity
    • Cui L., Schinaze R.F., Gosselin G., Imbach J-L., Chu C.K., Rando R.F., Revankar G.R., Sommadossi J-P. Effect of beta-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells: implication for predicting drug hepatotoxicity. Biochem. Pharmacol. 52:1996;1577-1584.
    • (1996) Biochem. Pharmacol. , vol.52 , pp. 1577-1584
    • Cui, L.1    Schinaze, R.F.2    Gosselin, G.3    Imbach, J.-L.4    Chu, C.K.5    Rando, R.F.6    Revankar, G.R.7    Sommadossi, J.-P.8
  • 8
    • 0023338271 scopus 로고
    • Growth and hepatospecific gene expression of huamn hepatoma cells in a defined medium
    • Darlington G.J., Kelly J.H., Buffone G.J. Growth and hepatospecific gene expression of huamn hepatoma cells in a defined medium. In Vitro Cell. Develop. Biol. 23(5):1987;349-354.
    • (1987) In Vitro Cell. Develop. Biol. , vol.23 , Issue.5 , pp. 349-354
    • Darlington, G.J.1    Kelly, J.H.2    Buffone, G.J.3
  • 9
    • 0028008640 scopus 로고
    • Fialuridine toxicity: New hopes and false downs
    • Dusheiko G.M. Fialuridine toxicity: new hopes and false downs. Intl. Antiviral News. 2:1994;22-23.
    • (1994) Intl. Antiviral News , vol.2 , pp. 22-23
    • Dusheiko, G.M.1
  • 10
    • 0025139031 scopus 로고
    • Inhibitory effects of 2′-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks
    • Fourel I., Hantz O., Watanabe K.A., Jacquet C., Chomel B., Fox J.J., Trepo C. Inhibitory effects of 2′-fluorinated arabinosyl-pyrimidine nucleosides on woodchuck hepatitis virus replication in chronically infected woodchucks. Antimicrob. Agents Chemother. 34:1990;473-475.
    • (1990) Antimicrob. Agents Chemother. , vol.34 , pp. 473-475
    • Fourel, I.1    Hantz, O.2    Watanabe, K.A.3    Jacquet, C.4    Chomel, B.5    Fox, J.J.6    Trepo, C.7
  • 11
    • 0024204662 scopus 로고
    • Incorporation and metabolism of 2′-fluoro-5-substituted arabinosyl pyrimidines and their selective inhibition of viral DNA synthesis in herpes simplex virus type 1 (HSV-1)-infected and mock-infected Vero cells
    • Kong X.B., Scheck A.C., Price R.W., Vidal P.M., Fanucchi M.P., Watanabe K.A., Fox J.J., Chou T.C. Incorporation and metabolism of 2′-fluoro-5-substituted arabinosyl pyrimidines and their selective inhibition of viral DNA synthesis in herpes simplex virus type 1 (HSV-1)-infected and mock-infected Vero cells. Antiviral Res. 10:1988;153-166.
    • (1988) Antiviral Res. , vol.10 , pp. 153-166
    • Kong, X.B.1    Scheck, A.C.2    Price, R.W.3    Vidal, P.M.4    Fanucchi, M.P.5    Watanabe, K.A.6    Fox, J.J.7    Chou, T.C.8
  • 12
    • 0026780779 scopus 로고
    • Preclinical pharmacology and pharmacokinetics of the anti-hepatitis virus agent 2′-fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil in mice and rats
    • Kong X.B., Vidal P., Tong W.P., Chiang J., Gloff C.A., Chou T.C. Preclinical pharmacology and pharmacokinetics of the anti-hepatitis virus agent 2′-fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil in mice and rats. Antimicrob. Agents Chemother. 36:1992;1472-1477.
    • (1992) Antimicrob. Agents Chemother. , vol.36 , pp. 1472-1477
    • Kong, X.B.1    Vidal, P.2    Tong, W.P.3    Chiang, J.4    Gloff, C.A.5    Chou, T.C.6
  • 13
    • 0026681374 scopus 로고
    • Zidovudine induces molecular, biochemical and ultrastructural changes in rat skeletal muscle mitochondra
    • Lewis W., Conzalez B., Chomyn A., Papoian T. Zidovudine induces molecular, biochemical and ultrastructural changes in rat skeletal muscle mitochondra. J. Clin. Invest. 89:1992;1354-1360.
    • (1992) J. Clin. Invest. , vol.89 , pp. 1354-1360
    • Lewis, W.1    Conzalez, B.2    Chomyn, A.3    Papoian, T.4
  • 15
    • 0000226527 scopus 로고
    • Mitochondrial toxicity of antiviral nucleoside analogs
    • Parker W.B., Cheng Y.C. Mitochondrial toxicity of antiviral nucleoside analogs. J. NIH Res. 6:1994;57-61.
    • (1994) J. NIH Res. , vol.6 , pp. 57-61
    • Parker, W.B.1    Cheng, Y.C.2
  • 17
    • 0025269583 scopus 로고
    • Inhibition of simian varicella virus infection of monkeys by 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-ethyluracil (D-FEAU) and synergistic effects of combination with human recombinant interferon-beta
    • Soike K.F., Chou T.C., Fox J.J., Watanabe K.A., Gloff C.A. Inhibition of simian varicella virus infection of monkeys by 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-ethyluracil (D-FEAU) and synergistic effects of combination with human recombinant interferon-beta. Antiviral Res. 13:1990;165-174.
    • (1990) Antiviral Res. , vol.13 , pp. 165-174
    • Soike, K.F.1    Chou, T.C.2    Fox, J.J.3    Watanabe, K.A.4    Gloff, C.A.5
  • 18
    • 0002063570 scopus 로고    scopus 로고
    • The woodchuck in preclinical assessment of therapy for hepatitis B virus infection
    • R.F. Schinazi, J.-P. Sommadossi, & H.C. Thomas. London: International Medical Press
    • Tennant B.C., Peek S.F., Tochkov I.A., Baldwin B.H., Hornbuckle W.E., Korba B.E., Cote P.J., Gerin J.L. The woodchuck in preclinical assessment of therapy for hepatitis B virus infection. Schinazi R.F., Sommadossi J.-P., Thomas H.C. Therapies for Viral Hepatitis. 1998;171-176 International Medical Press, London.
    • (1998) Therapies for Viral Hepatitis , pp. 171-176
    • Tennant, B.C.1    Peek, S.F.2    Tochkov, I.A.3    Baldwin, B.H.4    Hornbuckle, W.E.5    Korba, B.E.6    Cote, P.J.7    Gerin, J.L.8
  • 19
    • 0002030697 scopus 로고
    • HBV-drug deaths prompt restudy of similar antivirals
    • Touchette N. HBV-drug deaths prompt restudy of similar antivirals. J. NIH Res. 5:1993;33-35.
    • (1993) J. NIH Res. , vol.5 , pp. 33-35
    • Touchette, N.1
  • 20
    • 0026501053 scopus 로고
    • Evaluation of 1-(2′-deoxy-2′-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil in a rabbit model of herpetic keratitis
    • Trousdale M.D., Law J.L., Yarber F.A., Watanabe K.A., Fox J.J. Evaluation of 1-(2′-deoxy-2′-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil in a rabbit model of herpetic keratitis. Antiviral Res. 17:1992;157-167.
    • (1992) Antiviral Res. , vol.17 , pp. 157-167
    • Trousdale, M.D.1    Law, J.L.2    Yarber, F.A.3    Watanabe, K.A.4    Fox, J.J.5
  • 21
    • 0028006997 scopus 로고
    • Effect of anti-HIV 2′-beta-fluoro-2′,3′-dideoxynucleoside analogs on the cellular content of mitochondrial DNA and on lactate production
    • Tsai C.H., Doong S.L., Johns D.G., Driscoll J.S., Cheng Y.C. Effect of anti-HIV 2′-beta-fluoro-2′,3′-dideoxynucleoside analogs on the cellular content of mitochondrial DNA and on lactate production. Biochem. Pharmacol. 48:1994;1477-1481.
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 1477-1481
    • Tsai, C.H.1    Doong, S.L.2    Johns, D.G.3    Driscoll, J.S.4    Cheng, Y.C.5
  • 22
    • 0026624980 scopus 로고
    • Disease of the mitochondrial DNA
    • Wallace D.C. Disease of the mitochondrial DNA. Ann. Rev. Biochem. 61:1992;1175-1212.
    • (1992) Ann. Rev. Biochem. , vol.61 , pp. 1175-1212
    • Wallace, D.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.