Langerhans' cell histiocytosis is caused by dysregulation of the E- cadherin-β-catenin cascade: A hypothesis

Immunology and Cell Biology

Volumn 77, Issue 5, 1999, Pages 460-467

  Leenen, Pieter JM ^a   Egeler, R Maarten ^b  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

catenin; Cell signalling; E cadherin; Langerhans' cell histiocytosis

Indexed keywords

BETA CATENIN; UVOMORULIN;

CELL ACTIVATION; CELL ADHESION; CELL MATURATION; DENDRITIC CELL; GENE CONTROL; HISTIOCYTOSIS; LANGERHANS CELL; REVIEW;

ANIMALS; BETA CATENIN; CADHERINS; CELL ADHESION; CYTOSKELETAL PROTEINS; DOWN-REGULATION; HISTIOCYTOSIS, LANGERHANS-CELL; HUMANS; LANGERHANS CELLS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; TRANS-ACTIVATORS; WNT2 PROTEIN;

EID: 0032832166     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1711.1999.00856.x     Document Type: Review

References (62)

1. 1 Schmitz L, Favara BE. Nosology and pathology of Langerhans cell histiocytosis. Hematol. Oncol. Clin. North Am. 1998; 12: 221-46.
2. 2 Arico M, Egeler RM. Clinical aspects of Langerhans cell histiocytosis. Hematol. Oncol. Clin. North Am. 1998; 12: 247-58.
3. 3 Willman CL, McClain KL. An update on clonality, cytokines, and viral etiology in Langerhans cell histiocytosis. Hematol. Oncol. Clin. North Am. 1998; 12: 407-16.
4. 4 Ilyas M, Tomlinson IP. The interactions of APC, E-cadherin and beta-catenin in tumour development and progression. J. Pathol. 1997; 182: 128-37.
5. 5 Hirohashi S. Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am. J. Pathol. 1998; 153: 333-9.
6. 6 de Graaf JH, Tamminga RY, Kamps WA, Timens W. Expression of cellular adhesion molecules in Langerhans cell histiocytosis and normal Langerhans cells. Am. J. Pathol. 1995; 147: 1161-71.
7. 7 Geissmann F, Emile JF, Andry P et al. Lack of expression of E-cadherin is associated with dissemination of Langerhans' cell histiocytosis and poor outcome. J. Pathol. 1997; 181: 301-4.
8. 8 de Graaf JH, Tamminga RY, Dam-Meiring A, Kamps WA, Timens W. The presence of cytokines in Langerhans' cell histiocytosis. J. Pathol. 1996; 180: 400-6.
9. 9 Egeler RM, Favara BE, van Meurs M, Laman JD, Claassen E. Differential in situ cytokine profiles of Langerhans-like cells and T-cells in Langerhans Cell Histiocytosis: Abundant expression of cytokines relevant to disease and treatment. Blood 1999; in press.
10. 10 Weintraub M, Bhatia KG, Chandra RS, Magrath IT, Ladisch S. p53 expression in Langerhans cell histiocytosis. J. Pediatr. Hematol. Oncol. 1998; 20: 12-17.
11. 11 Takeichi M. The cadherin cell adhesion receptor family: Roles in multicellular organization and neurogenesis. Prog. Clin. Biol. Res. 1994; 390: 145-53.
12. 12 Birchmeier W. E-cadherin as a tumor (invasion) suppressor gene. Bioessays 1995; 17: 97-9.
13. 13 Udey MC. Cadherins and Langerhans cell immunobiology. Clin. Exp. Immunol. 1997; 107: 6-8.
14. 14 Mbalaviele G, Chen H, Boyce BF, Mundy GR, Yoneda T. The role of cadherin in the generation of multinucleated osteoclasts from mononuclear precursors in murine marrow. J. Clin. Invent. 1995; 95: 2757-65.
15. 15 Armeanu S, Buhring HJ, Reuss-Borst M, Muller CA, Klein G. E-cadherin is functionally involved in the maturation of the erythroid lineage. J. Cell Biol. 1995; 131: 243-9.
16. 16 Jakob T, Brown MJ, Udey MC. Characterization of E-cadherin-containing junctions involving skin-derived dendritic cells. J. Invest. Dermatol. 1999; 112: 102-8.
17. 17 Schwarzenberger K, Udey MC. Contact allergens and epidermal proinflammatory cytokines modulate Langerhans cell E-cadherin expression in situ. J. Invest. Dermatol. 1996; 106: 553-8.
18. 18 Jakob T, Udey MC. Regulation of E-cadherin-mediated adhesion in Langerhans cell-like dendritic cells by inflammatory mediators that mobilize Langerhans cells in vivo. J. Immunol. 1998; 160: 4067-73.
19. 19 Rambukkana A, Pistoor FH, Bos JD, Kapsenberg ML, Das PK. Effects of contact allergens on human Langerhans cells in skin organ culture: Migration, modulation of cell surface molecules, and early expression of interleukin-1 beta protein. Lab. Invest. 1996; 74: 422-36.
20. 20 Wang B, Kondo S, Shivji GM, Fujisawa H, Mak TW, Sauder DN. Tumour necrosis factor receptor II (p75) signalling is required for the migration of Langerhans' cells. Immunology 1996; 88: 284-8.
21. 21 Daniel JM, Reynolds AB. Tyrosine phosphorylation and cadherin/catenin function. Bioessays 1997; 19: 883-91.
22. 22 Miller JR, Moon RT. Signal transduction through beta-catenin and specification of cell fate during embryogenesis. Genes Dev. 1996; 10: 2527-39.
23. 23 Calautti E, Cabodi S, Stein PL, Hatzfeld M, Kedersha N, Paolo Dotto G. Tyrosine phosphorylation and src family kinases control keratinocyte cell-cell adhesion. J. Cell Biol. 1998; 141: 1449-65.
24. 24 Kanai Y, Ochiai A, Shibata T et al. c-erbB-2 gene product directly associates with beta-catenin and plakoglobin. Biochem. Biophys. Res. Commun. 1995; 208: 1067-72.
25. 25 Kypta RM, Su H, Reichardt LF. Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex. J. Cell Biol. 1996; 134: 1519-29.
26. 26 Gumbiner BM. Cell adhesion: The molecular basis of tissue architecture and morphogenesis. Cell 1996; 84: 345-57.
27. 27 Dale TC. Signal transduction by the Wnt family of ligands. Biochem. J. 1998; 329: 209-23.
28. 28 Clevers H, van de Wetering M. TCF/LEF factor earn their wings. Trends Genet. 1997; 13: 485-9.
29. 29 Eastman Q, Grosschedl R. Regulation of LEF-1/TCF transcription factors by Wnt and other signals. Curr. Opin. Cell Biol. 1999; 11: 233-40.
30. 30 Nusse R. WNT targets. Repression and activation. Trends Genet. 1999; 15: 1-3.
31. 31 He TC, Sparks AB, Rago C et al. Identification of c-MYC as a target of the APC pathway. Science 1998; 281: 1509-12.
32. 32 Behrens J, Jerchow BA, Wurtcle M et al. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science 1998; 280: 596-9.
33. 33 Hinck L, Nelson WJ, Papkoff J. Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin. J. Cell Biol. 1994; 124: 729-41.
34. 34 Moon RT, Brown JD, Torres M. WNTs modulated cell fate and behavior during vertebrate development. Trends Genet. 1997; 13: 157-62.
35. 35 Wong GT, Gavin BJ, McMahon AP. Differential transformation of mammary epithelial cells by Wnt genes. Mol. Cell. Biol. 1994; 14: 6278-86.
36. 36 Larabell CA, Torres M, Rowning BA et al. Establishment of the dorso-ventral axis in Xenopus embryos is presaged by early asymmetries in beta-catenin that are modulated by the Wnt signaling pathway. J. Cell Biol. 1997; 136: 1123-36.
37. 37 Huber O, Korn R, McLaughlin J, Ohsugi M, Herrmann BG, Kemler R. Nuclear localization of beta-catenin by interaction with transcription factor LEF-1, Mech, Dev, 1996; 59: 3-10.
38. 38 Saitoh A, Hansen LA, Vogel JC, Udey MC. Characterization of Wnt gene expression in murine skin: Possible involvement of epidermis-derived Wnt-4 in cutaneous epithelial-mesenchymal interactions. Exp. Cell Res. 1998; 243: 150-60.
39. 39 Iozzo RV, Eichstetter I, Danielson KG. Aberrant expression of the growth factor Wnt-5A in human malignancy. Cancer Res. 1995; 55: 3495-9.
40. 40 Wang J, Shackleford GM. Murine Wnt 10a and Wnt 10b: Cloning and expression in developing limbs, face and skin of embryos and in adults. Oncogene 1996; 13: 1537-44.
41. 41 Austin TW, Solar GP, Ziegler FC, Liem L, Matthews W. A role for the Wnt gene family in hematopoiesis: Expansion of multi-lineage progenitor cells. Blood 1997; 89: 3624-35.
42. 42 Van Den Berg DJ, Sharma AK, Bruno E, Huffman R. Role of members of the Wnt gene family in human hematopoiesis. Blood 1998; 92: 3189-202.
43. 43 Hardiman G, Albright S, Tsunoda J, McClanahan T, Lee F. The mouse Wnt-10B gene isolated from helper T cells is widely expressed and a possible oncogene in BR6 mouse mammary tumorigenesis. Gene 1996; 172: 199-205.
44. 44 Vleminckx KL, Deman JJ, Bruyneel EA et al. Enlarged cell-associated proteoglycans abolish E-cadherin functionality in invasive tumor cells. Cancer Res. 1994; 54: 873-7.
45. 45 Polakis P. The oncogenic activation of beta-catenin. Curr. Opin. Genet. Dev 1999; 9: 15-21.
46. 46 Ewing CM, Ru N, Morton RA et al. Chromosome 5 suppresses tumorigenicity of PC3 prostate cancer cells: correlation with re-expression of alpha-catenin and restoration of E-cadherin function. Cancer Res. 1995; 55: 4813-17.
47. 47 Bergstein I, Schultz R, Osborne MP, Welcsh PL, Bowcock AM, Brown AM. Investigation of the possible role of WNT genes in human breast cancer. Ann. N. Y. Acad. Sci. 1995; 768: 257.
48. 48 Christiansen JH, Monkley SJ, Wainwright BJ. Murine WNT11 is a secreted glycoprotein that morphologically transforms mammary epithelial cells. Oncogene 1996; 12: 2705-11.
49. 49 Callahan R. MMTV-induced mutations in mouse mammary tumors: their potential relevance to human breast cancer. Breast Cancer Res. Treat. 1996; 39: 33-44.
50. 50 Huguet EL, McMahon JA, McMahon AP, Bicknell R, Harris AL. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res. 1994; 54: 2615-21.
51. 51 Dale TC, Weber-Hall SJ, Smith K et al. Compartment switching of WNT-2 expression in human breast tumors. Cancer Res. 1996; 56: 4320-3.
52. 52 Katoh M, Hirai M, Sugimura T, Terada M. Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family. Oncogene 1996; 13: 873-6.
53. 53 Vider BZ, Zimber A, Chastre E et al. Evidence for the involvement of the Wnt 2 gene in human colorectal cancer. Oncogene 1996; 12: 153-8.
54. 54 Olson DJ, Gibo DM. Antisense wnt-5a mimics wnt-1-mediated C57MG mammary epithelial cell transformation. Exp. Cell Res. 1998; 241: 134-41.
55. 55 Chu T, Jaffe R. The normal Langerhans cell and the LCH cell. Br. J. Cancer 1994; 70: S4-10.
56. 56 Czernielewski JM, Demarchez M. Further evidence for the self-reproducing capacity of Langerhans cells in human skin. J. Invest. Dermatol. 1987; 88: 17-20.
57. 57 Miyauchi S, Hashimoto K. Mitotic activities of normal epidermal Langerhans cells. J. Invent. Dermatol. 1989; 92: 120-1.
58. 58 Salomon B, Cohen JL, Masurier C, Klatzmann D. Three populations of mouse lymph node dendritic cells with different origins and dynamics. J. Immunol. 1998; 160: 708-17.
59. 59 Abdelatif OM, Chandler FW, Pantazis CG, McGuire BS. Enhanced expression of c-myc and H-ras oncogenes in Letterer-Siwe disease. A sequential study using colorimetric in situ hybridization. Arch. Pathol. Lab. Med. 1990; 114: 1254-60.
60. 60 Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrity-linked kinase. Proc. Natl Acad. Sci. USA 1998; 95: 11211-16.
61. 61 Novak A, Hsu SC, Leung-Hagesteijn C et al. Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways. Proc. Natl Acad. Sci. USA 1998; 95: 4374-9.
62. 62 Huang Y, Wu C. Integrin-linked kinase and associated proteins. Int. J. Mol. Med. 1999; 3: 563-72.