Effect of the meglitinide analog S21403 on cationic fluxes and insulin release in perifused rat pancreatic islets exposed to a high concentration of D-glucose

Pharmacological Research

Volumn 40, Issue 3, 1999, Pages 297-300

  Louchami, K ^a   Jijakli, H ^a   Malaisse, W J ^a  

^a FREE UNIVERSITY OF BRUSSELS   (Belgium)

Author keywords

Cationic fluxes; Pancreatic islets; S21043

Indexed keywords

ANTIDIABETIC AGENT; CALCIUM ION; GLUCOSE; MEGLITINIDE; MITIGLINIDE; RUBIDIUM ION; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CATION TRANSPORT; CONTROLLED STUDY; DRUG EFFECT; EXTRACELLULAR CALCIUM; FEMALE; INSULIN LIKE ACTIVITY; INSULIN RELEASE; ISOTOPE LABELING; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; RAT;

EID: 0032831885     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1999.0513     Document Type: Article

References (15)

1. + channels by a non-sulfonylurea compound KAD-1229 in a pancreatic β-cell line, MIN 6 cell. Eur J Pharmacol 1994; 269: 293-8.
2. Ohnota H, Kobayashi M, Koizumi T, Katsuno K, Sato F, Aizawa T. In vitro insulinotropic action of a new non-sulfonylurea hypoglycemic agent, calcium (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate dihydrate (KAD-1229), in rat pancreatic B-cells. Biochem Pharmacol 1995; 49: 165-71.
3. Malaisse WJ, Sato F. Insulinotropic action of (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate. I. Secretory and cationic aspects. Gen Pharmac 1995; 26: 1313-8.
4. 45Ca outflow and insulin release. Diab Res 1996; 31: 27-31.
5. Malaisse-Lagae F, Malaisse WJ. Insulin release by pancreatic islets. In: Methods in diabetes research. Lamer J, Pohl SL, eds. Vol. 1, part B. New York: John Wiley, 1984: 147-52.
6. 86Rb outflow from pancreatic islets. I. Reciprocal changes in the response to glucose, tetraethylammonium and quinine. Mol Cell Endocrinol 1980; 17: 103-10.
7. Herchuelz A, Sener A, Malaisse WJ. Regulation of calcium fluxes in rat pancreatic islets. Calcium extrusion by sodium-calcium counter transport. J Membr Biol 1980; 57: 1-12.
8. Herchuelz A, Malaisse WJ. Regulation of calcium fluxes in pancreatic islets. Dissociation between calcium and insulin release. J Physiol (London) 1978; 283: 409-24.
9. Leclercq-Meyer V, Marchand J, Woussen-Colle MC, Giroix M-H, Malaisse WJ. Multiple effects of leucine on glucagon, insulin and somatostatin secretion from the perfused rat pancreas. Endocrinology 1985; 116: 1168-74.
10. Jijakli H, Ulusoy S, Malaisse WJ. Dissociation between the potency and reversibility of the insulinotropic action of two meglitinide analogues. Pharmacol Res 1996; 34: 105-8.
11. + efflux from perifused islets. Am J Physiol 1979; 236: E139-46.
12. Lebrun P, Malaisse WJ. Cationic and secretory effects of glimepiride and glibenclamide in perifused rat islets. Pharmacol Toxicol 1992; 70: 357-60.
13. Malaisse WJ, Lebrun P. Iterative stimulation of pancreatic islets by glipizide. Pharmacology 1993; 46: 43-9.
14. Louchami K, Jijakli H, Sener A, Malaisse WJ. Effect of repaglinide upon nutrient metabolism, biosynthetic activity, cationic fluxes and insulin release in rat pancreatic islets. Res Commun Mol Pathol Pharmacol 1998; 99: 155-68.
15. Gomis R, Mathias PCF, Lebrun P, Malaisse-Lagae F, Sener A, Malaisse WJ. Inhibition of transglutaminase by hypoglycaemic sulphonylureas in pancreatic islets and its possible relevance to insulin release. Res Commun Chem Pathol Pharmacol 1984; 46: 331-49.