Autoreactive IgG to intracellular proteins in sera of MS patients

Journal of Neuroimmunology

Volumn 99, Issue 1, 1999, Pages 72-81

  Lu, Fengmin ^a   Kalman, Bernadette ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Autoantibodies; Intracellular autoantigens; Multiple sclerosis

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIBODY; CELL PROTEIN; DEOXYRIBONUCLEASE; IMMUNOGLOBULIN G; PHOSPHOPROTEIN; PROTEIN HYDROLYSATE; PROTEINASE K; RIBONUCLEASE; RIBONUCLEOPROTEIN;

ANTIBODY TITER; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOBLOTTING; IMMUNOREACTIVITY; LEUKEMIA CELL LINE; MULTIPLE SCLEROSIS; OXIDATIVE STRESS; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANTIBODIES, ANTINUCLEAR; ANTIBODY SPECIFICITY; ANTIGENS, CD95; APOPTOSIS; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNE DISEASES; BLOTTING, WESTERN; DNA DAMAGE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLOW CYTOMETRY; HUMANS; HYDROGEN PEROXIDE; IMMUNOGLOBULIN G; INTRACELLULAR FLUID; JURKAT CELLS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MULTIPLE SCLEROSIS; NEOPLASM PROTEINS; OXIDATIVE STRESS; PHOSPHOPROTEINS; ULTRAVIOLET RAYS;

EID: 0032831746     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(99)00104-6     Document Type: Article

References (42)

1. Aisen M.L., Aisen P.S. Antinuclear antibodies in multiple sclerosis. Neurology. 45:1995;2299.
2. Archelos J.J., Trotter J., Previtali S., Weissbrich B., Toyka K.V., Hartung H.P. Isolation and characterization of an oligodendrocyte precursor-derived B-cell epitope in multiple sclerosis. Ann. Neurol. 43:1998;14-24.
3. Bagasra O., Michaels F.H., Zheng M.Y., Bobroski L.E., Spitsin S.V., Fu Z.F., Tawadros R., Koprowski H. Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis. Proc. Natl. Acad. Sci. USA. 92:1995;12041-12045.
4. Barned S., Goodman A.D., Mattson D.H. Frequency of antinuclear antibodies in multiple sclerosis. Neurology. 45:1995;384-385.
5. Becker K.G., Mattson D.H., Powers J.M., Gado A.M., Biddison W.E. Analysis of a sequenced cDNA library from multiple sclerosis lesions. J. Neuroimmunol. 77:1997;27-38.
6. Becker K.G., Simon R.M., Bailey-Wilson J.E., Freidlin B., Biddison W.E., McFarland H.F., Trent J.M. Clustering of non-major histocompatibility complex susceptibility loci in human autoimmune diseases. Proc. Natl. Acad. Sci. USA. 95:1998;9979-9984.
7. Bo L., Dawson T.M., Wesselingh S., Mork S., Choi S., Kong P.A., Hanley D., Trapp B.D. Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann. Neurol. 36:1994;778-786.
8. Bonetti B., Raine C.S. Multiple sclerosis: oligodendrocytes display cell death-related molecules in situ but do not undergo apoptosis. Ann. Neurol. 42:1997;74-84.
9. Bruck W., Bitsch A., Kolenda H., Bruck Y., Stiefel M., Lassmann H. Inflammatory central nervous system demyelination: correlation of magnetic resonance imaging findings with lesion pathology. Ann. Neurol. 42:1997;783-793.
10. Capello E., Voskuhl R., McFarland H.F., Raine C.S. Multiple sclerosis: re-expression of a developmental gene in chronic lesions correlates with remyelination. Ann. Neurol. 41:1997;797-805.
11. Chou Y.K., Bourdette D.N., Offner H., Whitham R., Wang R.Y., Hashim G.A., Vandenbark A.A. Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis. J. Neuroimmunol. 38:1992;105-113.
12. Collard R.C., Koehler R.P.M., Mattson D.H. Frequency and significance of antinuclear antibodies in multiple sclerosis. Neurology. 49:1997;857-861.
13. Colombo E., Banki K., Tatum A.H., Daucher J., Ferrante P., Murray R.S., Phillips P.E., Perl A. Comparative analysis of antibody and cell-mediated autoimmunity to transaldolase and myelin basic protein in patients with multiple sclerosis. J. Clin. Invest. 99:1997;1238-1250.
14. Crambach A., Rodbard D. Polyacrylamide gel electrophoresis. Science. 172:1971;440-450.
15. Dandona P., Thusu K., Cook S., Snyder B., Makowski J., Amstrong D., Nicotera S. Oxidative damage to DNA in diabetes mellitus. Lancet. 347:1996;444-445.
16. Dore-Duffy P., Donaldson J.O., Rothman B.L., Zurier R.B. Antinuclear antibodies in multiple sclerosis. Arch. Neurol. 39:1982;504-506.
17. Driggers W.J., Holmquist G.P., LeDoux S.P., Wilson G.L. Mapping frequencies of endogenous oxidative damage and the kinetic response to oxidative stress in a region of rat mtDNA. Nucleic Acids Res. 25:1997;4362-4369.
18. Genain C.P., Canella B., Hauser S.L., Raine C.S. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat. Med. 5:1999;170-175.
19. Guilbert B., Dighiero G., Avrameas S. Naturally occurring antibodies against nine common antigens in human sera: I. Detection. Isolation and characterization. J. Immunol. 128:1982;2779-2787.
20. Johnson D., Hafler D.A., Fallis R.J.et al. Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis. J. Neuroimmunol. 13:1986;99-108.
21. Martin R., Whiteker J.N., Rhame L., Goodin R.R., McFarland H.F. Citrulline-containing myelin basic protein is recognized by T-cell lines derived from multiple sclerosis patients and healthy individuals. Neurology. 44:1994;123-129.
22. Mattson D.H., Ross R.P., Arnason B.G.W. Isoelectric focusing of IgG eluted from multiple sclerosis and subacute sclerosing panencephalitis brains. Nature. 287:1980;335-337.
23. Mattson D. Antinuclear antibodies in multiple sclerosis. Neurology. 45:1995;2300-2301.
24. McCombe P.A., Chalk J.B., Pender M.P. Familial occurrence of multiple sclerosis with thyroid disease and systemic lupus erythematosus. J. Neurol. Sci. 97:1990;163-171.
25. Miller D.J., Njenga M.K., Murray P.D., Leibowitz J., Rodriguez M. A monoclonal natural antibody that promotes remyelination suppresses central nervous system inflammation and increases virus expression after Theiler's virus-induced demyelination. Int. Immunol. 8:1996;131-141.
26. Pfeifer G.P., Drouin R., Riggs A.D., Holmquist G.P. In vivo mapping of a DNA adduct at nucleotide resolution: detection of pyrimidine (6-4) pyridone photoproducts by ligation-mediated polymerase chain reaction. Proc. Natl. Acad. Sci. U.S.A. 88:1991;1374-1378.
27. Pfeifer G.P., Drouin R., Holmquist G.P. Detection of DNA adducts at the DNA sequence level by ligation-mediated PCR. Mutation Res, 288:1993;39-46.
28. Poser C.M., Paty D.W., Scheinberg L.et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann. Neurol. 13:1983;227-231.
29. Powell T., Sussman J.G., Davies-Jones G.A.B. MR Imaging in acute multiple sclerosis: ringlike appearance in plaques suggesting the presence of paramagnetic free radicals. AJNR. 13:1992;1544-1546.
30. Raine C.S. The Dale E. McFarlin memorial lecture: the immunology of the multiple sclerosis lesion. Ann. Neurol. 36:1994;S61-S72.
31. Richert J.R., Robinson E.D., Deibler G.E., Martenson R.E., Dragovic L.J., Kies M.W. Evidence for multiple human T cell recognition sites on myelin basic protein. J. Neuroimmunol. 23:1989;55-66.
32. Sellebjerg F.T., Frederiksen J.L., Olsson T. Anti-myelin basic protein and anti-proteolipid protein antibody-secreting cells in the cerebrospinal fluid of patients with acute optic neuritis. Arch. Neurol. 51:1994;1032-1036.
33. Sun J., Link H., Olsson T., Xiao B.G., Anderson G., Ekre H.P., Linington C., Diener P. T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis. J. Immunol. 146:1991;1490-1495.
34. Tobin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA. 76:1979;4350-4354.
35. Utz P.J., Hottelet M., Schur P.H., Anderson P. Proteins phosphorylated during stress induced apoptosis are common targets for autoantibody production in patients with systemic lupus erythematosus. J. Exp. Med. 185:1997;843-854.
36. Vladimirova O., O'Connor J., Cahill A., Alder H., Kalman B. Oxidative damage to DNA in plaques of MS brains. Mult. Scler. 4:1998;413-418.
37. Vladimirova, O., Lu, F., Shawver, L., Kalman, B., 1999. The activation of protein kinase C induces higher production of reactive oxygen species by mononuclear cells in patients with multiple sclerosis than in controls. Inflammation Res. (submitted).
38. von Muhlen C.A., Tan E.M. Autoantibodies in the diagnosis of systemic rheumatic diseases. Semin. Arthritis Rheum. 24:1995;323-358.
39. Voskuhl R.R., McFarlin D.E., Tranquill L.R., Deibler G., Stone R., Maloni H., McFarland H.F. A novel candidate autoantigen in a multiplex family with multiple sclerosis: prevalence of T-lymphocytes for an MBP epitope unique to myelination. J. Neuroimmunol. 46:1993;137-144.
40. Walsh M.J., Murray J.M. Dual implication of 2′,3′-cyclic nucleotide 3′ phosphodiesterase as major antigen and C3 complement-binding protein in the pathogenesis of multiple sclerosis. J. Clin. Invest. 101:1998;1923-1931.
41. Warren K.G., Catz I. The effect of intrathecal MBP synthetic peptides containing epitope P85 VVHFFKNIVTP98 on free anti-MBP levels in acute relapsing multiple sclerosis. J. Neurol. Sci. 148:1997;67-68.
42. Wood D.D., Bilbao J.M., O'Connors P., Moscarello M.A. Acute multiple sclerosis (Marburg type) is associated with developmentally immature myelin basic protein. Ann. Neurol. 40:1996;18-24.