Short-term dose-response relationships for the relative systemic effects of oral prednisolone and inhaled fluticasone in asthmatic adults

British Journal of Clinical Pharmacology

Volumn 48, Issue 4, 1999, Pages 579-585

  Wilson, A M ^a   Lipworth, B J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Adrenal suppression; Asthma; Bone markers; Corticosteroids; Eosinophils; Fluticasone propionate; Prednisolone

Indexed keywords

ANTIASTHMATIC AGENT; FLUTICASONE PROPIONATE; HYDROCORTISONE; OSTEOCALCIN; PREDNISOLONE;

ADRENAL SUPPRESSION; ADULT; ARTICLE; ASTHMA; CELL COUNT; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG POTENCY; EOSINOPHIL; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; HYDROCORTISONE BLOOD LEVEL; INHALATIONAL DRUG ADMINISTRATION; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; ADRENAL GLANDS; ADULT; ANDROSTADIENES; ANTI-ASTHMATIC AGENTS; ANTI-INFLAMMATORY AGENTS; ASTHMA; BIOLOGICAL MARKERS; BONE AND BONES; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; EOSINOPHILS; FEMALE; HUMANS; HYDROCORTISONE; MALE; OSTEOCALCIN; PREDNISOLONE; TIME FACTORS;

EID: 0032828308     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1999.00058.x     Document Type: Article

References (26)

1. 1 British Thoracic Society. The British Guidelines on asthma management: 1995 review and position statement. Thorax 1997; 52(Suppl 1): S1-S21.
2. 2 Lipworth BJ. Airway and systemic effects of inhaled corticosteroids in asthma: dose response relationship. Pulm Pharmacol 1996; 9: 19-27.
3. 3 Lipworth BJ, Seckl JL. Measures for detecting systemic bioactivity with inhaled and intranasal corticosteroids. Thorax 1997, 52: 476-482.
4. 4 Toogood JH, Baskerville J, Jennings B, Lefcoe NM, Johannsson SA. Bioequivalent doses of budesonide and prednisone in moderate and severe asthma. J Allergy Clin Immunol 1989; 84: 668-700.
5. 5 Clark DJ, Lipworth BJ. Adrenal suppression with chronic dosing of fluticasone propionate compared with budesonide in adult asthmatic patients. Thorax 1997; 52: 55-58.
6. 6 Boorsma M, Andersson N, Larsson P, Ullman A. Assessment of the relative systemic potency of inhaled fluticasone and budesonide. Eur Respir J 1996; 9: 1427-1432.
7. 7 Wilson AM, McFarlane LC, Lipworth BJ. Dose response effect for adrenal suppression with repeated twice daily inhaled fluticasone priopionate and triamcinolone acetonide in adult asthmatics. Am J Respir Crit Care Med 1997; 156: 1274-1277.
8. 8 Jennings BH, Anderson KE, Johannsson SA. Assessment of systemic effects of inhaled glucocorticoids: comparison of the effects of inhaled budesonide and oral prednisolone on adrenal function and markers of bone turnover. Eur J Clin Pharmacol 1989; 40: 77-82.
9. 9 Phillips GH. Structure-activity relationships of topically active steroids: the selection of fluticasone propionate. Respir Med 1990; 84(Suppl A): 19-23.
10. 10 English AF, Neate MS, Quint DJ, Sareen M. Biological activities of some corticosteroids used in asthma. Am J Respir Crit Care Med 1994; 149(Suppl): A212.
11. 11 Brown PH, Blundell G, Greening AP, Crompton GK. Screening for hypothalamo-pituitary-adrenal axis suppression in asthmatics taking high doses of inhaled corticosteroid. Respir Med 1991; 85: 511-516.
12. 12 Broide J, Soferman R, Kivity S, Golander A, Dickstein G, Spirer Z, Weisman Y. Low dose adrenocorticotropin test reveals impaired adrenal function in patients taking inhaled corticosteroids. J Clin Endocrinol Metab 1995; 80: 1243-1246.
13. 13 Grebe SKG, Feek CM, Durham JA, Kjakovic M, Cooke R. Inhaled beclomethasone dipropionate suppresses the hypothalamic pituitary adrenal axis in a dose dependent manner. Clin Endocrinol 1997; 47: 297-304.
14. 14 Harding SM. The human pharmacology of fluticasone propionate. Respir Med 1990; 84(Suppl A): 25-29.
15. 15 Lipworth BJ. Pharmacokinetics of inhaled drugs. Br J Clin Pharmacol 1996; 42: 697-705.
16. 16 Grahnen A, Jansson B, Brunden RM, et al. A dose response study comparing suppression of plasma cortisol induced by fluticasone propionate from diskhaler and budesonide from turbuhaler. Eur J Clin Pharmacol 1997; 52: 261-267.
17. 17 Donnelly R, Williams KM, Baker B, Badcock CA, Day RO, Seal PJ. Effects of budesonide and fluticasone on 24 hour plasma cortisol: a dose response study. Am J Respir Crit Care Med 1997; 156: 1746-1751.
18. 18 Wilson AM, Lipworth BJ. 24 hour profiles of adrenocortical activity in asthmatic patients receiving inhaled and intranasal corticosteroids. Thorax 1999; 54: 20-27.
19. 19 Meibholm B, Hochhaus G, Rahatagi S, et al. Dependency of cortisol suppression on the administration time of inhaled corticosteroids. J Clin Pharmacol 1997; 37: 704-710.
20. 20 Thorsson L, Dahlstrom K, Edsbacker S, Kallen A, Paulson J, Wiren JE. Pharmacokinetics and systemic effects of inhaled fluticasone propionate in healthy subjects. Br J Clin Pharmacol 1997; 43: 155-161.
21. 21 Wilson AM, Clark DJ, Devlin M, McFarlane LC, Lipworth BJ. Adrenocortical activity with repeated administration of once daily inhaled fluticasone propionate and budesonide in asthamtic adults. Eur J Clin Pharmacol 1998, 53: 317-320.
22. 22 Adair CG, McCallion O, McFarlane LC. A pharmacokinetic and pharmacodynamic comparison of plain and enteric coated prednisolone tablets. Br J Clin Pharmacol 1992; 33: 495-499.
23. 23 Noonan M, Chervinsky P, Busse WW, et al. Fluticasone propionate reduces oral prednisolone use while it improves asthma control and quality of life. Am J Respir Crit Care Med 1995; 152: 1467-1473.
24. 24 Zimmerman B, Gold M, Wherrett D, Hanna AK. Adrenal suppression in two patients with asthma treated with low doses of inhaled steroid fluticasone propionate. J Allergy Clin Immunol 1998; 101: 425-426.
25. 25 Duplantier JE, Nelson RP, Morelli AR, Good RA, Kornfeld SJ. Hypothalamic-pituitary-adrenal axis suppression associated with the use of inhaled fluticasone propionate. J Allergy Clin Immunol 1998; 102: 699-700.
26. 26 Todd GRG, Wright D, Ryan M. Acute adrenal insufficiency in a patient with asthma after changing from fluticasone propionate to budesonide. J Allergy Clin Immunol 1999; 103: 956-957.