An in vivo evaluation of the therapeutic potential of sympatholytic agents on premature ejaculation

BJU International

Volumn 84, Issue 4, 1999, Pages 503-506

  Hsieh, J T ^a   Liu, S P ^a   Hsieh, C H ^a   Cheng, J T ^b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Premature ejaculation; Seminal vesicle; Sympatholytic agents; Wistar rat

Indexed keywords

2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; ADRENERGIC RECEPTOR BLOCKING AGENT; CHLOROETHYLCLONIDINE; PHENOXYBENZAMINE; PRAZOSIN; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; ELECTROSTIMULATION; INTRAARTERIAL DRUG ADMINISTRATION; MALE; NONHUMAN; PREMATURE EJACULATION; PRESSURE; PRIORITY JOURNAL; RAT; SEMINAL VESICLE; SPLANCHNIC NERVE; STATISTICAL ANALYSIS;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EJACULATION; MALE; RATS; RATS, WISTAR; SEXUAL DYSFUNCTION, PHYSIOLOGICAL;

EID: 0032824550     PISSN: 14644096     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-410x.1999.00173.x     Document Type: Article

References (19)

1. 1 Bitran D, Hull EM. Pharmacological analysis of male rat sexual behavior. Neurosci Biobehav Rev 1987; 11: 365-89
2. 2 Kimura Y, Kisaki N, Sakurada S, Tadano T. On the brain monoaminergic systems relating to ejaculation. I. Brain dopamine and ejaculation. Andrologia 1976; 8: 313-20
3. 3 Kimura Y, Kisaki N, Sakurada S, Tadano T. On the brain monoaminergic systems relating to ejaculation. II. Brain serotonin and ejaculation. Andrologia 1977; 9: 50-4
4. 4 Shilon M, Paz GF, Homonnai ZT. The use of phenoxybenzamine treatment in premature ejaculation. Fertil Steril 1984; 42: 659-66
5. 5 Hsieh JT, Chien CT. Liu SP, Chen CF, Lai MK. An experimental model to evaluate the in vivo response of rat seminal vesicle to electrical stimulation. Neurosci Lett 1996; 204: 215-7
6. 6 Hsieh JT, Chang HC, Law HS, Hsieh CH, Cheng JT. In vivo evaluation of serotoninergic agents and α-adrenergic blockers on premature ejaculation by inhibiting the seminal vesicle pressure response to electrical nerve stimulation. Br J Urol 1998; 82: 237-40
7. 7 Brindley GS. Physiology of erection and management of paraplegic infertility. In Hargreave TB, ed, Male Infertility. Chapt 15. New York: Springer-Verlag, 1983: 261-79
8. 8 Kedia K, Markland C. The effect of pharmacological agents on ejaculation. J Urol 1975; 114: 569-73
9. 9 Caine M. Clinical experience with alpha adrenoreceptor antagonists in benign prostatic hypertrophy. Fed Proc 1986; 45: 2604-6
10. 10 Segraves RT. Sexual side-effects of psychiatric drugs. Int J Psychiatry Med 1988; 18: 243
11. 11 Cavallini G. Alpha-1 blockade pharmacotherapy in primitive psychogenic premature ejaculation resistant to psychotherapy. Eur Urol 1995; 28: 126-30
12. 12 Kara H, Aydin S, Agargun MY, Odabas O, Yilmaz Y. The efficacy of fluoxetine in the treatment of premature ejaculation: a double-blind placebo study. J Urol 1996; 156: 1631-2
13. 13 Kaplan PM. The use of serotoninergic uptake inhibitors in the treatment of premature ejaculation. J Sex Marital Ther 1994; 20: 321-4
14. 14 Montejo-Gonzalez AL, Llorca G, Izquierdo JA et al. SSRI induced sexual dysfunction: Fluoxetine, paroxetine, Sertraline and fluvoxamine in a prospective, multicenter and descriptive clinical study of 344 patients. J Sex Marital Ther 1997; 23: 176-94
15. 2-adrenoceptors in rats. Br J Pharmacol 1985; 84 (Suppl): 193
16. 16 Donatucci CF. Prosexual drugs: oral topical agents for enhancing erectile and ejaculatory control. Proceedings of the 93rd AUA Annual Meeting. Office of Education, San Diego, LA, May 30-June 4 1998
17. 17 Kenakin T. Drug-Receptor Theory. In Kenakin T, ed. Pharmacologic Analysis of Drug-Receptor Interaction, 3rd edn, Chapt 1. Philadelphia: Lippincott-Raven 1997: 3
18. 18 Cooper AJ, Cernovsky ZZ, Colussi K. Some clinical and psychometric characteristics of primary and secondary premature ejaculators. J Sex Marital Ther 1993; 19: 276-88
19. 19 Knoll LD, Benson RC, Bilhartz DL, Minich PJ, Furlow WL. A randomized crossover study using yohimbine and isoxsuprine versus pentoxifylline in the management of vasculogenic impotence. J Urol 1996; 155: 144-6