Racial differences in the correlation between gonadal androgens and serum insulin levels

Diabetes Care

Volumn 22, Issue 9, 1999, Pages 1524-1529

  Kitabchi, Abbas E ^a,b   Imseis, Raed E ^a   Bush, Andrew J ^a   Williams Cleaves, Beverly ^a   Pourmotabbed, Ghassem ^a  

^a UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; C PEPTIDE; FOLLITROPIN; GLUCOSE; INSULIN; LUTEINIZING HORMONE; PRASTERONE; PRASTERONE SULFATE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CAUCASIAN; FEMALE; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; NEGRO; OBESITY; PREMENOPAUSE; RACE; RACE DIFFERENCE; RADIOIMMUNOASSAY;

ADOLESCENT; ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; ANDROSTENEDIONE; BODY MASS INDEX; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; DEMOGRAPHY; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FOLLICLE STIMULATING HORMONE; HUMANS; INSULIN; LUTEINIZING HORMONE; PREMENOPAUSE; TESTOSTERONE;

EID: 0032822887     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.22.9.1524     Document Type: Article

References (38)

1. Achard C, Thiers J: Le virilism pilaire et son association à l'insufficience glycolytique (diabète à femmes de barbe). Bull Acad Natl Med (Paris) 86:51-55, 1921
2. Kahn CR, Flier JS, Bar RS, Archer JA, Gorden P, Martin MM, Roth J: The syndromes of insulin resistance and acanthosis nigricans. N Engl J Med 294:739-745, 1976
3. Burghen GA, Givens RA, Kitabchi AE: Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease. J Clin Endocrinol Metab 50:113-116, 1980
4. Barbieri RL, Ryan KJ: Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: a common endocrinopathy with distinct pathophysiologic features. Am J Obstet Gynecol 147:90-101, 1983
5. Shoupe D, Lobo RA: The influence of androgens on insulin resistance. Fertil Steril 41: 385-388, 1984
6. Chang RJ, Nakamura RM, Judd HL, Kaplan SA: Insulin resistance in nonobese patients with polycystic ovarian disease. J Clin Endocrinol Metab 57:356-359, 1983
7. Schriock ED, Buffington CK, Hubert GD, Kurtz BR, Kitabchi AE, Buster JE, Givens JR: Divergent correlations of circulating dehydroepiandrosterone sulfate and testosterone with insulin levels and insulin receptor binding. J Clin Endocrinol Metab 66:1329-31, 1988
8. Evans DJ, Hoffmann RG, Kalkhoff RK, Kissebah AH: Relationship of androgenic activity to body fat topography, fat cell morphology, and metabolic aberrations in premenopausal women. J Clin Endocrinol Metab 57:304-310, 1983
9. Peiris AN, Mueller RA, Struve MF, Smith GA, Kissebah AH: Relationship of androgenic activity to splanchnic insulin metabolism and peripheral glucose utilization in premenopausal women. J Clin Endocrinol Metab 64:162-169, 1987
10. Ibanez L, Potau N, Zampolli M, Prat N, Virdis R, Vicens-Calvet E, Carrascosa A: Hyperinsulinemia in postpubertal girls with a history of premature pubarche and functional ovarian hyperandrogenism. J Clin Endocrinol Metab 81:1237-1243, 1996
11. Hauner H, Ditschuneit HH, Pal SB, Moncayo R, Pfeiffer EF: Fat distribution, endocrine and metabolic profile in obese women with and without hirsutism. Metabolism 37:281-286, 1988
12. Toscano V, Bianchi P, Balducci R, Guglielmi R, Mangiantini A, Lubrano C, Sciarra F: Lack of linear relationship between hyperinsulinaemia and hyperandrogenism. Clin Endocrinol 36:197-202, 1992
13. Tai MM: A mathematical model for the determination of total area under glucose tolerance and other metabolic curves. Diabetes Care 17:152-154, 1994
14. Bonora E, Moghetti P, Zancanaro C, Cigolini M, Querena M, Cacciatori V, Corgnati A, Muggeo M: Estimates of in vivo insulin action in man: comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies. J Clin Endocrinol Metab 68:374-378, 1989
15. Akinmokun A, Selby PL, Ramaiya K, Alberti KG: The short insulin tolerance test for determination of insulin sensitivity: a comparison with the euglycaemic clamp. Diabet Med 9:432-437, 1992
16. Hirst S, Phillips DI, Vines SK, Clark PM, Hales CN: Reproducibility of the short insulin tolerance test. Diabet Med 10: 839-842, 1993
17. Young RP, Critchley JA, Anderson PJ, Lau MS, Lee KK, Chan JC: The short insulin tolerance tests: feasibility study using venous sampling. Diabet Med 13:429-433, 1996
18. Dowling HJ, Pi-Sunyer FX: Race-dependent health risks of upper body obesity. Diabetes, 42:537-543, 1993
19. Conway JM, Yanovski SZ, Avila NA, Hubbard VS: Visceral adipose tissue differences in black and white women. Am J Clin Nutr 61:765-771, 1995
20. Lovejoy JC, de la Bretonne JA, Klemperer M, Tulley R: Abdominal fat distribution and metabolic risk factors: effects of race. Metabolism 45:1119-1124, 1996
21. Albu JB, Murphy L, Frager DH, Johnson JA, Pi-Sunyer FX: Visceral fat and race-dependent health risks in obese nondiabetic premenopausal women. Diabetes 46:456-462, 1997
22. Kitabchi AE, Imseis RE, Bush AJ, Reddick W, Kauffman W, Gronemeyer S: Racial differences in the correlation between gonadal androgens and hyperinsulinemia (Abstract). Diabetes 47 (Suppl. 1):A404, 1998
23. Kitabchi AE, Buffington CK: Body fat distribution, hyperandrogenicity, and health risks. In Seminars in Reproductive Endocrinology. Speroft L, Ed. New York, Thieme, 1994, p. 6-14
24. Buffington CK, Givens JR, Kitabchi AE: Opposing actions of dehydroepiandrosterone and testosterone on insulin sensitivity: in vivo and in vitro studies of hyperandrogenic females. Diabetes 40: 693-700, 1991
25. Kitabchi AE, Buffington CK, Givens JR, Inouye H: Role of adrenal and gonadal androgens in insulin action and metabolism. Folia Endocrinologica Japonica 67: 203-213, 1991
26. Ovesen P, MollerJ, Ingerslev JH, Jorgensen JO, Mengel A, Schmitz O, Alberti KG, Moller N: Normal basal and insulin stimulated fuel metabolism in lean women with polycystic ovary syndrome. J Clin Endocrinol Metab 77:1636-1640, 1993
27. Buffington CK, Pourmotabbed G, Kitabchi AE: Case report: amelioration of insulin resistance in diabetes with dehydroepiandrosterone. Am J Med Sci 306: 320-324, 1993
28. Woodard TL, Burghen GA, Kitabchi AE: Glucose intolerance and insulin resistance in aplastic anemia treated with oxymethalone. J Clin Endocrinol Metab 53:905-908, 1981
29. Farah MJ, Givens JR, Kitabchi AE: Bimodal correlation between the circulating insulin level and the productin rate of dehydroepiandrosterone: positive correlation in normal and obese controls, and negative correlation in polycystic ovarian disease with acanthosis nigricans. J Clin Endocrinol Metab 70:1075-1081, 1990
30. Peiris AN, Aiman EJ, Drucker WD, Kissebah AH: The relative contributions of hepatic and peripheral tissues to insulin resistance in hyperandrogenic women. J Clin Endocrinol Metab 68:715-720, 1989
31. Buffington CK, Kitabchi AE: Evidence for a defect in insulin metabolism in hyperandrogenic women with polycystic ovarian syndrome. Metabolism 43:1367-1372, 1994
32. Osei K, Cottrell DA, Harris B: Differences in basal and poststimulation glucose homeostasis in nondiabetic first degree relatives of black and white patients with type 2 diabetes mellitus. J Clin Endocrinol Metab 75: 82-86, 1992
33. Cowie CC, Harris MI, Silverman RE, Johnson EW, Rust KF: Effect of multiple risk factors on differences between blacks and whites in the prevalence of non-insulin-dependent diabetes mellitus in the United States. Am J Epidemiol 137:719-732, 1993
34. Osei K, Schuster DP: Ethnic differences in secretion, sensitivity, and hepatic extraction of insulin in black and white Americans. Diabet Med 11:755-762, 1994
35. Haffner SM, D'Agostino R, Saad MF, Rewers M, Mykkanen L, Selby J, Howard G, Savage PJ, Hamman RF, Wagenknecht LE: Increased insulin resistance and insulin secretion in nondiabetic African-Americans and Hispanics compared with non-Hispanic whites: the Insulin Resistance Atherosclerosis Study. Diabetes 45:742-748, 1996
36. Tull ES, Roseman JM: Diabetes in African-Americans. In Diabetes in America. 2nd ed. Harris MI, Cowie CC, Stern MP, Boyko EJ, Reiber GE, Bennett PH, Eds. Washington, DC, U.S. Govt. Printing Office, 1995, p. 613-630 (NIH publ. no. 95-1468)
37. Kumanyika S: Obesity in black women. Epidemiol Rev 9:31-50, 1987
38. Gillum RE Grant CT: Coronary heart disease in black populations. II. Risk factors. Am Heart J 104:852-864, 1982