The relationship between QT intervals and mortality in ambulant patients with chronic heart failure. The United Kingdom Heart Failure Evaluation and Assessment of Risk Trial (UK-HEART)

European Heart Journal

Volumn 20, Issue 18, 1999, Pages 1335-1341

  Brooksby, P ^a,e   Batin, P D ^b   Nolan, J ^b   Lindsay, S J ^b   Andrews, R ^a   Mullen, M ^c   Baig, W ^c   Flapan, A D ^d   Prescott, R J ^d   Neilson, J M M ^d   Cowley, A J ^a   Fox, K A A ^d  

^a NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^b Yorkshire Heart Centre   (United Kingdom)

^c DONCASTER ROYAL INFIRMARY   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e Pontefract General Infirmary   (United Kingdom)

Author keywords

Cardiac; Congestive; Death; Electrocardiology; Heart failure; Mortality; QT dispersion; QT intervals; Sudden

Indexed keywords

CREATININE;

ADULT; AGED; ARTICLE; CREATININE BLOOD LEVEL; DIAGNOSTIC VALUE; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; HEART ARRHYTHMIA; HEART FAILURE; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART RATE; HOLTER MONITORING; HUMAN; MAJOR CLINICAL STUDY; MORTALITY; MULTIVARIATE ANALYSIS; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; QT INTERVAL; RISK ASSESSMENT; SUDDEN DEATH; THORAX RADIOGRAPHY; UNITED KINGDOM;

DEATH, SUDDEN, CARDIAC; ELECTROCARDIOGRAPHY, AMBULATORY; FEMALE; GREAT BRITAIN; HEART CONDUCTION SYSTEM; HEART FAILURE, CONGESTIVE; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES;

EID: 0032820864     PISSN: 0195668X     EISSN: None     Source Type: Journal    
DOI: 10.1053/euhj.1999.1542     Document Type: Article

References (39)

1. McKee PA, Castelli WP, McNamara PM, Kannel WB. The natural history of congestive heart failure: the Framingham study. N Engl J Med 1971; 285: 1441-6.
2. The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 1991; 325: 293-302.
3. The CONSENSUS trial study group. Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med 1987; 316: 1429-35.
4. Rector TS, Cohn JN. Prognosis in congestive heart failure. Annu Rev Med 1994; 45: 341-50.
5. Carson P, Johnson G, Fletcher R, Cohn J. Mild systolic dysfunction in heart failure (left ventricular ejection fraction > 35%): baseline characteristics, prognosis and response to therapy in the vasodilator in heart failure trials (V-HeFT). J Am Coll Cardiol 1996; 27: 642-9.
6. Goldman S, Johnson G, Cohn JN, Cintron G, Smith R, Francis G. Mechanism of death in heart failure. The vasodilator-heart failure trials. Circulation 1993; 87 (Suppl VI): V124-V131.
7. Gradman A, Deedwania P, Cody R, Massie B, Packer M, Goldstein S. Predictors of total mortality in congestive heart failure. J Am Coll Cardiol 1989; 14: 564-70.
8. De Luna AB, Coumel P, Leclerq JF. Ambulatory sudden cardiac death: mechanisms of production of fatal arrhythmia on the basis of data from 157 cases. Am Heart J 1989; 117: 151-9.
9. Luu M, Stevenson WG, Stevenson LW, Baron K, Walden J. Diverse mechanisms of unexpected cardiac arrest in advanced heart failure. Circulation 1989; 80: 1675-80.
10. Day CP, McComb JM, Campbell RWF. QT dispersion: an indication of arrhythmia risk in patients with long QT intervals. Br Heart J 1990; 63: 342-4.
11. Higham PD, Hilton CJ, Aitcheson JD, Furniss SS, Bourke JP, Campbell RWF. Does QT dispersion reflect dispersion of ventricular recovery? Circulation 1992; 86: I-392.
12. Higham PD, Furniss SS, Campbell RWF. Acute myocardial infarction, reperfusion and QT dispersion. J Am Coll Cardiol 1992; 19: 304A.
13. Potratz J, Wiegand U, Brandes A et al. Late potentials, heart rate variability and QT-dispersion in patients with implanted cardioverter-defibrillator (Abstr). Eur Heart J 1996; 17 (Abstr Suppl): 384.
14. Perkiomaki JS, Koistinen MJ, YliMayry S, Huikuri HV. Dispersion of QT interval in patients with and without susceptibility to ventricular tachyarrhythmias after previous myocardial infarction. J Am Coll Cardiol 1995; 26: 174-9.
15. Pye M, Quinn AC, Cobe SM. QT interval dispersion: A non-invasive marker of susceptibility to arrhythmia in patients with sustained ventricular arrhythmias? Br Heart J 1994; 71: 511-4.
16. Buja G, Miorelli M, Turrini P, Melacini P, Nava A. Comparison of QT dispersion in hypertrophic cardiomyopathy between patients with and without ventricular arrhythmias and sudden death. Am J Cardiol 1993; 72: 973-6.
17. Barr CS, Naas A, Freeman M, Lang CC, Struthers AD. QT dispersion and sudden unexpected death in chronic heart failure. Lancet 1994; 343 (8893): 327-9.
18. Fu G-S, Meissner A, Simon R. Repolarization dispersion and sudden cardiac death in patients with impaired left ventricular function. Eur Heart J 1997; 18: 281-9.
19. Fei L, Goldman JH, Prasad K, Keeling PJ et al. QT dispersion and RR variations on 12-lead ECGs in patients with congestive heart failure secondary to idiopathic dilated cardiomyopathy. Eur Heart J 1996; 17: 258-63.
20. Strunk-Mueller C, Gietzen F, Kuhn H. QTc dispersion in dilated cardiomyopathy - a new method for stratifying the risk of sudden cardiac death (Abstr). Eur Heart J 1996; 17 (Abstr Suppl): 276.
21. Puddu PE, Bourassa MG. Prediction of sudden death from QTc interval prolongation in patients with chronic ischemic heart disease. J Electrocardiol 1986; 19: 203-12..
22. Schwartz PJ, Wolf S. QT interval prolongation as predictor of sudden death in patients with myocardial infarction. Circulation 1978; 57: 1074-7.
23. Peters RW, Byington RP, Barker A, Yusuf S. Prognostic value of prolonged ventricular repolarisation following myocardial infarction: the BHAT experience. J Clin Epidemiol 1990; 43: 167-72.
24. Moller M. QT interval in relation to ventricular arrhythmias and sudden death in postmyocardial infarction patients. Acta Med Scand 1981; 210: 73-7.
25. Nolan J, Batin PD, Andrews R et al. A prospective study of heart rate variability and mortality in chronic heart failure; Results of the United Kingdom heart failure evaluation and assessment of risk trial (UK-HEART). Circulation 1998; In press.
26. Cohn JN, Johnson GR, Shabetai R et al. Ejection fraction, peak exercise oxygen consumption, cardiothoracic ratio, ventricular arrhythmias, and plasma norepinephrine as determinants of prognosis in heart failure. Circulation 1993; 87 (6 S VI): V15-V16.
27. Cleland JGF Dargie HF, Ford I. Mortality in heart failure; Clinical variables of prognostic value. Br Heart J 1987; 58: 572-82.
28. Greene H, Richardson D, Barker A et al. Classification of deaths after myocardial infarction as arrhythmic or non-arrhythmic. Am J Cardiol 1989; 63: 1-6.
29. Cox DR. Regression models and life tables. J Roy Stat Soc 1972; 34: 187-202.
30. Lee AFC, Hanson J, Kennedy N, Struthers AD. QT dispersion is related to an increased end diastolic volume on MUGA scan (Abstr). Eur Heart J 1996; 17 (Abstr Suppl): 277.
31. Bonnar CE, Gillespie ND, MacFayden RJ, Ogston SS, Struthers AD. QT-dispersion is significantly increased between 6am and 8am in heart failure patients - a possible role in sudden death? J Am Coll Cardiol 1997; 29 (Suppl A): 510A.
32. Bonnar CE, MacFayden RJ, Robson JM, Duncan AM, Struthers AD. QT-dispersion is related to autonomic tone in patients with stable chronic heart failure (Abstr). Eur Heart J 1997; 18 (Abstr Suppl): 200.
33. Lowe MD, Ludman PF, Rowland E, Grace AA. B-adrenoceptor stimulation increases dispersion of cardiac repolarisation (Abstr). Clin Sci 1997; 93.
34. Pinsky DJ, Sciacca RR, Steinberg JS. QT dispersion as a marker of risk in patients awaiting heart transplantation. J Am Coll Cardiol 1997; 29: 1576-84.
35. Pratt CM, Greenway PS, Schoenfeld MH, Hibben ML, Reiffel JA. Exploration of the precision of classifying sudden cardiac death. Implications for the interpretation of clinical trials. Circulation 1996; 93: 519-24.
36. Cui G, Sen L, Fonarow GC et al. QT dispersion and malignant ventricular arrhythmia in patients with end-stage heart failure caused by ischemic vs. idiopathic cardiomyopathy. J Am Coll Cardiol 1996; 27 (Suppl. A): 121A.
37. Fei L, Statters DJ, Camm AJ. QT-interval dispersion on 12-lead electrocardiogram in normal subjects: Its reproducibility and relation to the T wave. Am Heart J 1994; 127: 1654-5.
38. Tsuij H, Veditti FJ, Evans JC, Larson MG, Levy M. The associations of levels of potassium and magnesium with ventricular premature complexes (the Framingham Heart Study). Am J Cardiol 1994; 74: 232-5.
39. Gettes L. Electrolyte abnormalities as triggers for lethal ventricular arrhythmias. In: Akhtar M, Myerburg RJ, Ruskin JN, eds. Sudden cardiac death. Philadelphia: Williams & Wilkins, 1994: 327-40.