Re-expression of SPR1 in breast cancer cells by phorbol 12-myristate 13- acetate (PMA) or UV irradiation is mediated by the AP-1 binding site in the SPR1 promoter

Molecular Medicine

Volumn 5, Issue 8, 1999, Pages 526-541

  Anisowicz, Anthony ^a   Sotiropoulou, Georgia ^b   Sager, Ruth ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF PATRAS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CHLORAMPHENICOL ACETYLTRANSFERASE; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; POLYPEPTIDE; PROLINE; TRANSCRIPTION FACTOR AP 1;

ARTICLE; BINDING SITE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL CULTURE; CONTROLLED STUDY; ENHANCER REGION; EPITHELIUM CELL; GENE DELETION; HUMAN; HUMAN CELL; MUTAGENESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; ULTRAVIOLET IRRADIATION;

EID: 0032820599     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03401980     Document Type: Article

References (44)

1. 1. Sager R. (1997) Expression genetics in cancer: Shifting the focus from DNA to RNA. Proc. Natl. Acad. Sci. U.S.A. 94: 952-955.
2. 2. Zou Z, Anisowicz A, Hendrix MJC, et al. (1994) Identification of a novel serpin with tumor suppressing activity in human mammary epithelial cells. Science 263: 526-529.
3. 3. Liang L, Pardee AB. (1992) Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 257: 967-970.
4. 4. Sager R, Anisowicz A, Neveu M, Liang P, Sotiropoulou G. (1993) Identification by differential display of alpha 6 integrin as a candidate tumor suppressor gene. FASEB J. 7: 964-970.
5. 5. Sager R, Sheng S, Anisowicz A, et al. (1994) RNA genetics of breast cancer: Maspin as a paradigm. Cold Spring Harb. Symp. Quant. Biol. 59: 537-546.
6. 6. Sotiropoulou G, Anisowicz A, Sager R. (1997) Identification, cloning and characterization of cystatin M, a novel cysteine proteinase inhibitor, down-regulated in breast cancer. J. Biol. Chem. 272: 903-910.
7. 7. Anisowicz A, Sotiropoulou G, Stenman G, Mok SC, Sager R. (1996) A novel prolease homolog differentially expressed in breast and ovarian cancer. Mol. Med. 2: 624-636.
8. 8. Zhang L, Zhou W, Velculescu VE, et al (1997) Gene expression profiles in normal and cancer cells. Science 276: 1268-1272.
9. 9. Kariasova T, van de Putte P. (1988) Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes. Mol. Cell. Biol. 8: 2195-2203.
10. 10. Kartasova T, Van Muijen GNP, van Pelt-Heerschap H, van de Putte P. (1988) Novel protein in human epidermal keratinocytes: Regulation of expression during differentiation. Mol. Cell. Biol. 8: 2204-2210.
11. 11. Gibbs S, Fijneman R, Wiegant J, Van Kessel G, van de Putte P, Backendorf C. (1993) Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. Genomics 16: 630-637.
12. 12. Lohman FP, Medema JK, Gibbs S, Ponec M, van de Putte P, Backendorf C. (1997) Expression of the SPRR cornification genes is differentially affected by carcinogenic transformation. Exp. Cell Res. 231: 141-148.
13. 13. Tesfaigzi J, An G, Wu R, Carbon DM. (1995) Two nuclear proteins in tracheal epithelial cells are recognized by antibodies specific to a squarnous differentiation marker, spr1. J. Cell. Physiol. 164: 571-578.
14. 14. Tesfaigzi J, Carlson DM. (1996) Expression of the spr1 gene in cultured tracheal epithelial cells and its regulation by retinoids before and after confluence. J. Cell Physiol 166: 480-486.
15. 15. DeMuth JP, Weaver DA, Crawford EL, Jackson CM, Willey JC. (1998) Loss of spr1 expression measurable by quantitative RT-PCR in human bronchogenic carcinoma cell lines. Am. J. Respir. Cell Mol. Biol 19: 25-29.
16. 16. An G, Tesfaigzi J, Chuu Y-J, Wu R. (1993) Isolation and characterization of the human spr1 gene and its regulation of expression by phorbol ester and cyclic AMP. J. Biol. Chem. 268: 10977-10982.
17. 17. Reddy SPM, Chuu Y-J, Lao PN, Donn J, Ann DK, Wu R. (1995) Expression of human squamous cell differentiation marker, SPR1, in tracheobronchial epithelium depends on JUN and TRE motifs. J. Biol. Chem. 270: 26451-26459.
18. 18. Band V, Zajchowski D, Swisshelm K, et al. (1990) Tumor progression in four mammary epithelial cell lines derived from the same patient. Cancer Res. 50: 7351-7357.
19. 19. Band V, Sager R. (1989) Distinctive traits of normal and tumor-derived human mammary epithelial cells expressed in a medium that supports long-term growth of both cell types. Proc. Natl. Acad. Sci. U.S.A. 86: 1249-1253.
20. 20. Feinberg AP, Vogelstein B. (1983) A technique for radiolabeling DNA restriction endonuclease fragments in high specific activity. Anal Biochem. 132: 6.
21. 21. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. (1990) Basic local alignment search tool. J. Mol. Biol. 215: 403-410.
22. 22. Masiakowski P, Breathnach R, Bloch J, Gannon F, Krust A, Chambon P. (1982) Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line. Nucl. Acids Res. 10: 7895-7903.
23. 23. Sambrook J, Fritsch EF, Maniatis T. (1989) Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
24. 24. Sassone-Corsi P, Verma IM. (1987) Modulation of c-fos gene transcription by negative and positive cellular factors. Nature 326: 507-510.
25. 25. Anisowicz A, Messinco M, Lee S, Sager R. (1991) An NF-κB-like transcription factor mediates IL-1/TNF-α induction of gro in human fibroblasts. J. Immunol 147: 520-527.
26. 26. Graham FL, van der Eb AJ. (1973) Transformation of rat cells by DNA of human adenovirus 5. Virology 54: 536-539.
27. 27. Fridovich-Keil JL, Gudas JM, Don Q-P, Bouvard I, Pardee AB. (1991) Growth-responsive expression from the murine thymidine kinase promoter: Genetic analysis of DNA sequences. Cell Growth Differ. 2: 67-76.
28. 28. German CM, Moffat LF, Howard BH. (1982) Recombinant genomes which expressed chloramphenicol acetyl transferase in mammalian cells. Mol. Cell. Biol. 2: 1044-1057.
29. 29. Chan GL, Little JB. (1976) Induction of oncogenic transformation in vitro by ultraviolet light. Nature 264: 442-444.
30. 30. Luckow B, Schutz G. (1987) CAT construction with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucl. Acids Res. 15: 5490.
31. 31. Zhang M, Magit D, Sager R. (1997) Expression of maspin in prostate cells is regulated by a positive Ets element and a negative hormonal responsive element site recognized by androhen receptor. Proc. Natl. Acad. Sci. U.S.A. 94: 974-979.
32. 32. Zhang M, Maass N, Magit D, Sager R. (1997) Transactivation through Ets and Ap1 transactivation sites determines the expression of the tumor-suppressing gene Maspin. Cell Growth Differ. 8: 179-186.
33. 33. Sutherland JA, Cook A, Bannister AJ, Kouzarides T. (1992) Conserved motifs in Fos and Jun define a new class of activation domains. Gene Dev. 6: 1810-1819.
34. 34. Halazonetis TD, Georgopoulos K, Greenberg ME, Ledr P. (1988) c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell 55: 917-924.
35. 35. Zhang M, Magit D, Pardee AB, Sager R. (1997) Re-expression of elafin in 21MT2 breast carcinomas by phorbol 12-myristate 13-acetate (PMA) is mediated by the Ap1 site in the elafin promoter. Cancer Res. 57: 4631-4636.
36. 36. Binetruy B, Smeal T, Karin M. (1991) Ha-ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature 351: 122-127.
37. 37. Dong Z, Birrer MJ, Watts RG, Matrisian LM, Colburn NH. (1994) Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epithermal cells. Proc. Natl. Acad. Sd. U.S.A. 91: 609-613.
38. 38. Li J-J, Westergaard C, Ghosh P, Colburn NH. (1997) Inhibitors of both nuclear factor-κB and activator protein-1 activation block the ncoplastic transformation response. Cancer Res. 57: 3569-3576.
39. 39. Smith LM, Birrer MJ, Stampfer MR, Brown PH. (1997) Breast cancer cells have lower activating protein 1 transcription factor activity than normal mammary epithelial cells. Cancer Res, 57: 3046-3054.
40. 40. Domann FE Jr, Levy JP, Finch JS, Bowden GT. (1994) Constitutive AP-1 DNA binding and transaciivating ability of malignant but not benign mouse 3pithermal cells. Mol. Carcinogen. 9; 61-66.
41. 41. Tyrrell RM, (1996) Activation of mammalian gene expression by the UV component of sunlight-from models to reality. BioEssays 18: 139-148.
42. 42. Gibbs S, Lohman F, Teubel W, van de Putte P, Backendorf C. (1990) Characterization of the human spr2 promoter: Induction after UV irradiation or TPA treatment and regulation during differentiation of cultured primary keratinocytes. Nucl. Adds Res, 18:4401-4407.
43. 43. Buscher M, Rahmsdorf HJ, Litfin M, Karin M, Herrlich P. (1988) Activation of the c-fos gene by UV and phorbol ester: Different signal transduction pathways converge to the same enhancer element. Oncogene 3: 301-311.
44. 44. Zhang M, Martin KJ, Sheng S, Sager R. (1998) Expression genetics: A different approach to cancer diagnosis and prognosis. Trends Biotechnol. 16: 66-71.